ID A0A452EJA3_CAPHI Unreviewed; 972 AA.
AC A0A452EJA3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=General vesicular transport factor p115 {ECO:0000256|ARBA:ARBA00018243};
GN Name=USO1 {ECO:0000313|Ensembl:ENSCHIP00000012115.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000012115.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000012115.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000012115.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the VDP/USO1/EDE1 family.
CC {ECO:0000256|ARBA:ARBA00006960}.
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DR EMBL; LWLT01000006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017905078.1; XM_018049589.1.
DR AlphaFoldDB; A0A452EJA3; -.
DR STRING; 9925.ENSCHIP00000012115; -.
DR Ensembl; ENSCHIT00000019905.1; ENSCHIP00000012115.1; ENSCHIG00000013930.1.
DR GeneID; 102184046; -.
DR KEGG; chx:102184046; -.
DR CTD; 8615; -.
DR GeneTree; ENSGT00390000017018; -.
DR OMA; LLDYEYC; -.
DR OrthoDB; 1774at2759; -.
DR Proteomes; UP000291000; Chromosome 6.
DR Bgee; ENSCHIG00000013930; Expressed in longissimus thoracis muscle and 16 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:InterPro.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:1900076; P:regulation of cellular response to insulin stimulus; IEA:Ensembl.
DR GO; GO:0032252; P:secretory granule localization; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:Ensembl.
DR GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR041209; P115_Arm_rpt.
DR InterPro; IPR006955; Uso1_p115_C.
DR InterPro; IPR006953; Vesicle_Uso1_P115_head.
DR PANTHER; PTHR10013; GENERAL VESICULAR TRANSPORT FACTOR P115; 1.
DR PANTHER; PTHR10013:SF0; GENERAL VESICULAR TRANSPORT FACTOR P115; 1.
DR Pfam; PF18770; Arm_vescicular; 1.
DR Pfam; PF04871; Uso1_p115_C; 1.
DR Pfam; PF04869; Uso1_p115_head; 1.
DR SMART; SM00185; ARM; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 60..97
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT DOMAIN 351..639
FT /note="Vesicle tethering protein Uso1/P115-like head"
FT /evidence="ECO:0000259|Pfam:PF04869"
FT DOMAIN 854..962
FT /note="Uso1/p115-like vesicle tethering protein C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04871"
FT REGION 774..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 663..711
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 860..915
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 946..965
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 972 AA; 108839 MW; 9920687569D781A4 CRC64;
MNFLRGVMGG QSAGPQHTEA ETIQKLCDRV ASSTLLDDRR DAVRALKSLS KKYRLEVGIQ
AMEHLIRVLQ TDRSDSEIIG YALDTLYNII SNDEEEEVDD VEEENSTRQS EDLGSQFTEI
FIKQQENVTL LLSLLEEFDF HVRWPGVKLL TSLLKQLGPQ VQQIILVSPM GVSRLMDLLA
DSREVIRNDG VLLLQALTRS NGAIQKIVAF ENAFERLLDI ITEEGNSDGG IVVEDCLILL
QNLLKNNNSN QNFFKEGSYI QRMKPWFEVG DENSGWSAQK VTNLHLMLQL VRVLVSPNNP
PGATSSCQKA MFQCGLLQQL CTILMATGVP ADILTETINT VSEVIRGCQV NQDYFASVNA
PSNPPRPAIV VLLMSMVNER QPFVLRCAVL YCFQCFLYKN QKGQGEIVST LLPSTIDATG
NTVSAGQLLC GGLFSTDSLS NWCAAVALAH ALQENATQKE QLLRVQLATS IGNPPVSLLQ
QCTNILSQGD KINRRGSKIQ TRVGLLMLLC TWLSNCPIAV THFLHNSANV PFLTGQIAEN
LGEEEQLVQG LCALLLGISI YFNDNSLETY MKEKLKQLIE KRIGKENFIE KLGFISKHEL
YSRASQKPQP NFPSPEYMIF DHEFTKLVKE LEGVITKAIY KSSEEDKKEE EVKKTLEQHD
SIVTHYKNMI REQDLQLEEL KQQISTLKCQ NEQLQTAVTQ QVSQIQQHKD QYNLLKVQLG
KDSQHQGPYS DGAQMNGIQP EEISRLREEI EELKSNRELL QSQLAEKDSL IENLKSSQPS
PGTNEQSSAT AGDSEQIAEL KQELATLKSQ LNSQSVEIAK LQTEKQELLQ KTEAFVKSAP
VPGESETVIA TKTTDVEGRL SALLQETKEL KNEIKALSEE RTAIKEQLDS SNSTIAILQN
EKNKLEVDII DAKREQDDLL VLLADQDQKI FSLKNKLKEL GHPVEEEDEL ESGDQDDEDD
EDEDDGKEQG HI
//
