ID A0A452EKF9_CAPHI Unreviewed; 204 AA.
AC A0A452EKF9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=CD74 molecule {ECO:0000313|Ensembl:ENSCHIP00000012362.1};
GN Name=CD74 {ECO:0000313|Ensembl:ENSCHIP00000012362.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000012362.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000012362.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000012362.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017905648.1; XM_018050159.1.
DR Ensembl; ENSCHIT00000020152.1; ENSCHIP00000012362.1; ENSCHIG00000014130.1.
DR Ensembl; ENSCHIT00010000611.1; ENSCHIP00010000399.1; ENSCHIG00010000371.1.
DR GeneID; 102185560; -.
DR CTD; 972; -.
DR GeneTree; ENSGT00390000008961; -.
DR OrthoDB; 2972165at2759; -.
DR Proteomes; UP000291000; Chromosome 7.
DR Proteomes; UP000694566; Chromosome 7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035718; F:macrophage migration inhibitory factor binding; IEA:InterPro.
DR GO; GO:0042289; F:MHC class II protein binding; IEA:InterPro.
DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0070206; P:protein trimerization; IEA:InterPro.
DR Gene3D; 1.10.870.10; MHC class II-associated invariant chain, trimerisation domain; 1.
DR InterPro; IPR043530; CD74_antigen.
DR InterPro; IPR015386; MHC_II-assoc_invar/CLIP_MHC-bd.
DR InterPro; IPR022339; MHC_II-assoc_invar_chain.
DR InterPro; IPR011988; MHC_II-assoc_invariant_trimer.
DR InterPro; IPR036613; MHCII_invariant_trimer_sf.
DR PANTHER; PTHR14093; HLA CLASS II GAMMA CHAIN; 1.
DR PANTHER; PTHR14093:SF17; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN; 1.
DR Pfam; PF09307; MHC2-interact; 1.
DR Pfam; PF08831; MHCassoc_trimer; 1.
DR PIRSF; PIRSF001992; CD74_antigen; 1.
DR PRINTS; PR01990; CD74ANTIGEN.
DR SUPFAM; SSF48305; Class II MHC-associated invariant chain ectoplasmic trimerization domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..105
FT /note="MHC class II-associated invariant chain/CLIP MHC II-
FT interacting"
FT /evidence="ECO:0000259|Pfam:PF09307"
FT DOMAIN 118..185
FT /note="MHC class II-associated invariant chain
FT trimerisation"
FT /evidence="ECO:0000259|Pfam:PF08831"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 204 AA; 23368 MW; 2C8BCB56BC7A39EC CRC64;
MEDQRDLISN HEQLPMLGQR PRAQESKCSR GALYTGFSVL VALLLAGQAT TAYFLYQQQG
RLDKLTVTSQ NLQLENLRMK LPKPAKPLSQ MRMATPMLMR ALPMAGPEPM KNATKYGNMT
QDHVMHLLLK ADPLKVYPQL KGSLPENLKH LKDSMDGLDW KLFENWLHQW LLFEMSKNSL
EEKPFEVPPK DPMEMEYPSS GLEV
//
