ID A0A452EKR3_CAPHI Unreviewed; 832 AA.
AC A0A452EKR3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA helicase MCM8 {ECO:0000256|ARBA:ARBA00041084};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=Minichromosome maintenance 8 {ECO:0000256|ARBA:ARBA00042306};
GN Name=MCM8 {ECO:0000313|Ensembl:ENSCHIP00000012725.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000012725.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000012725.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000012725.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC ECO:0000256|RuleBase:RU004070}.
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DR EMBL; LWLT01000014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452EKR3; -.
DR Ensembl; ENSCHIT00000020516.1; ENSCHIP00000012725.1; ENSCHIG00000014359.1.
DR GeneTree; ENSGT01090000260080; -.
DR OMA; THTVDWQ; -.
DR Proteomes; UP000291000; Chromosome 13.
DR Bgee; ENSCHIG00000014359; Expressed in thymus and 15 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR CDD; cd17759; MCM8; 1.
DR CDD; cd22247; MCM8_WHD; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF47; DNA HELICASE MCM8; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 394..601
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 832 AA; 92580 MW; 4B23AEFBCCA30505 CRC64;
MNGKYRGRGF GQGRFQSWKS GRGGGGLSGK WRGREHRPDL SKATGKHPEQ TPQSLLLQST
LDQFIPYKGW KLYFSEVYSD SMPFIEKIEA FESFFTERIE LYDKDEIERK GSILVDFKEL
TNDDEITKLI PNIANELRDT PEKTLACMGL AIHQVLTKDL ERHAAELQAQ EGLSRNGETV
VNVPRIHARV YNYEPLTQLK NVRANYYGKY IALRGTVVRV SNTKPLCTKM AFLCAACGEI
QSFSLPDGKY NLPTKCPVPA CRGKSFTALP SSPLTVTMDW QSIKIQELMS DDQREAGRIP
RTIECELVHD LVDSCVPGDT VTITGVVKVS NAEEGSRNKN DKCMFLLYIE ANSVSNNKGQ
KTKASEDGCK HGALMEFSLK DLYAIQEIQS EENLFKLIVK YFCFIIYMLG LVKAGLALAL
FGGSQKYADD KNRIPIRGDP HVLVVGDPGL GKSQMLQAVC SVAPRGVYVC GNTTTTSGLT
VTLSKDSSSG DFALEAGALV LGDQGICGID EFDKMGNQHQ ALLEAMEQQS ISLAKAGMVC
SLPARTSIIA AANPVGGHYN KAKTVSENLK MGSALLSRFD LVFILLDTPN EDHDHLLSEH
VIAIRAGKQR AVSSATVARI NSQDSNTSIL EVVSDKPLSE RLKVVPGETI DPIPHQLLRK
YIGYSRQYVY PRLSTEAAQI LQDFYLELRK QSQRLSSSPI TTRQLESLIR LTEARARLEL
REEATKEDAE DIVEIMKYSM LGTYSDEFGN LDFERSQHGS GMSNRSAAKR FISALNNIAE
RTYNNLFQFH QLQQIAKELN IQVADFENFI GSLNDQGYLL KKGPKVYQLQ TM
//
