ID A0A452ELB1_CAPHI Unreviewed; 629 AA.
AC A0A452ELB1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Solute carrier family 7 member 4 {ECO:0000313|Ensembl:ENSCHIP00000012873.1};
GN Name=SLC7A4 {ECO:0000313|Ensembl:ENSCHIP00000012873.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000012873.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000012873.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_017900317.1; XM_018044828.1.
DR RefSeq; XP_017900318.1; XM_018044829.1.
DR AlphaFoldDB; A0A452ELB1; -.
DR STRING; 9925.ENSCHIP00000012873; -.
DR Ensembl; ENSCHIT00000020664.1; ENSCHIP00000012873.1; ENSCHIG00000014492.1.
DR GeneID; 102174111; -.
DR KEGG; chx:102174111; -.
DR CTD; 6545; -.
DR GeneTree; ENSGT00940000154637; -.
DR OMA; WFAKTHP; -.
DR OrthoDB; 1421713at2759; -.
DR Proteomes; UP000291000; Unassembled WGS sequence.
DR Bgee; ENSCHIG00000014492; Expressed in fallopian tube and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR029485; CAT_C.
DR PANTHER; PTHR43243:SF89; CATIONIC AMINO ACID TRANSPORTER 4; 1.
DR PANTHER; PTHR43243; INNER MEMBRANE TRANSPORTER YGJI-RELATED; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
DR PIRSF; PIRSF006060; AA_transporter; 2.
PE 4: Predicted;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022970}.
FT TRANSMEM 39..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 540..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 538..588
FT /note="Cationic amino acid transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13906"
SQ SEQUENCE 629 AA; 67328 MW; 03CF5ACB71EE0941 CRC64;
MAPGRPCAAG LARFCQKLKR QKPLEDSAME TSLQRCLSTL DLTLLGVGSM VGSGLYVLTG
TVAKEITGPA VIVSFVVAAV ASLMAALCYA EFGARVPRTG SAYLFTYVSM GELWAFLIGW
NLVLEYVIAG AAVARAWSGY LDAMFNHRIH NFTEAHLGIW QVPFLARSPD WLAAGIVLLA
SAFVSCGARV SSWLNHTLSA VSMVVILFII VLGFILARPS NWGEAEGGFA PFGFSGIMSG
TATCFYAFVG FDVIAASSEE ARNPKRAVPL AVALSLGLAA SAYILVSAVL TLMIPWHSLN
PNSALADAFY QRGYGWAGYL VATGSICAMT TVQLNGLFCL PRIIYAMAVD GLFFEAFAYV
HPRTQVPLLG ILVFGALTAV VTLLLDIEAL VQFLSIGTLL AYTFVAISVL ALRFQTASQP
GSPSLSGSSL RAKEYSSFSD HLELVGTGHG PEPGRLRPAL RPYLGFLDRG SPGAAVRGAI
CGLVVSAVAL GCVLMLGHSV LHLPLWGFLL LLLCSGIMFL LSLLVLGAHQ QQRLKDTFQM
PLVPLIPALS IVLNFCLMLK LSYLTWLRFT IWLLMGLSVY LGYGVWHSKE NWREPPGLVT
ARHAAFPNGR LEETAQDPGQ ALAQGPGSP
//
