ID A0A452ELR2_CAPHI Unreviewed; 1209 AA.
AC A0A452ELR2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSCHIP00000012976.1};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSCHIP00000012976.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000012976.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000012976.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000012976.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; LWLT01000006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452ELR2; -.
DR STRING; 9925.ENSCHIP00000012976; -.
DR Ensembl; ENSCHIT00000020767.1; ENSCHIP00000012976.1; ENSCHIG00000014543.1.
DR GeneTree; ENSGT00940000154127; -.
DR OMA; IFFAQIK; -.
DR Proteomes; UP000291000; Chromosome 6.
DR Bgee; ENSCHIG00000014543; Expressed in testis and 16 other cell types or tissues.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0098797; C:plasma membrane protein complex; IEA:Ensembl.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 197..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 360..390
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 607..634
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 978..1012
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1209 AA; 137548 MW; F056771EB6A41DB2 CRC64;
MKFSKEIEVF NPPLASAASS EPWVHSVFAF THSWPRKTLF KRDSAVTHRL YGDISRDIQG
TSENGVIFQK CAVVSVQSEW PSAHVRLFVN NTRTPTAANL SDLLILDNIT GLTVRESAGN
QTSRGFQAFR KKFLQVGDSF SVSYTASLEA RDVRSGDILL LPAQLSFQSS SPNRTQLRAP
FTITAEEKIT VLPNHGLHAA GFCVAFILSL VLTWAVLFFM VRYQCVKGSL LSRHQVQHHE
NKLEHSQFTS ADGVNEDLAL NDQMIDILSS EDTGSMLQAL EELEIATLNR ADSDLEACRT
QISKDIIALL LKNLTSSGQL SPQVERRMGA VFKKQFLLLE KEIQEEYDRK MVALAAECDL
ETRKKTESQY QREMAALEEA EEVLKRVSER SAVECSSLLR TLHGLEQEHL RRSLALQQEE
DFAKAHRQLA IFQRNELHNI FFTQIKSAIS KGELKPEAAK MLLQDYSKIQ ESVEELMDFF
QASKRYHLSK RFGHREYLVQ NIQSSETRVQ GLLSTASAQL TLLIQKHERA GYLDEDQMQV
LLERAQTEVF SIKQKLDNDL KQEKKKLHQK LIIKRRREML QKHKEQRREQ LSIAEASGAA
EDAGQYLGQW RGLMAEHSAA LEELQERLDQ AALDELRALT LSLSEKATEE LRRLQNSGMT
QELLKRGVPW LFLQQILEEH GRDLAARAER LEGEERDRGQ EGVQSVRQRL KDDALEASTE
EQAELRHWEH LIFTKLCSSA FSLSEEELLG LRQEVHGCFA QMDRSLALPK IRARVLLQRF
QTAWREAEFL KLDQAVAAPE LQPQSKARKP RSKSRSKIDL LKKCIEDKIQ LFEEQAPEDL
VEKVRGELLR ERVQQLEAQE GLFAESLVSL QFQKAGRMAR TLWAYTALLS IQDLLLEELS
ASETLTKSAC MQILESHSPE LQELERKLED QLAHQEAAQL QRALDSWQQW AGEGPGLLQE
PEETDSERQV SAVLQRALSK GQKLLERHQQ SLRKEQEDSV MLEDLLENME TDTFVTLYGQ
ELRLASYLSK LTMLPGSTLR RLLTVALPAA SQAELVAVLD SVGQKHQDHV VENNGSGVQA
DLGRRGKHQG WWQALESKLR GELISRGLEK MLWARKRKES ILKKTCPPLR ERVIFSGKGS
WPHLSLESTD ELTPVPIVGA EAVDLLNTGE KLFIFRNPKE PEISLHVPPR KKKKNFLNTK
KAAWALGMN
//