ID A0A452EMF0_CAPHI Unreviewed; 1087 AA.
AC A0A452EMF0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Dishevelled associated activator of morphogenesis 2 {ECO:0000313|Ensembl:ENSCHIP00000013273.1};
GN Name=DAAM2 {ECO:0000313|Ensembl:ENSCHIP00000013273.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000013273.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000013273.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000013273.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452EMF0; -.
DR STRING; 9925.ENSCHIP00000013273; -.
DR Ensembl; ENSCHIT00000021065.1; ENSCHIP00000013273.1; ENSCHIG00000014706.1.
DR GeneTree; ENSGT00940000157801; -.
DR Proteomes; UP000291000; Chromosome 23.
DR Bgee; ENSCHIG00000014706; Expressed in prefrontal cortex and 16 other cell types or tissues.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0021516; P:dorsal spinal cord development; IEA:Ensembl.
DR GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; IEA:Ensembl.
DR GO; GO:0090521; P:podocyte cell migration; IEA:Ensembl.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:0051489; P:regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:2000050; P:regulation of non-canonical Wnt signaling pathway; IEA:Ensembl.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45725:SF7; DISHEVELED-ASSOCIATED ACTIVATOR OF MORPHOGENESIS 2; 1.
DR PANTHER; PTHR45725; FORMIN HOMOLOGY 2 FAMILY MEMBER; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 40..416
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 595..1014
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1036..1067
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 514..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 434..510
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 708..735
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 985..1021
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1087 AA; 124805 MW; 0AB699EE61F932C2 CRC64;
MAPRKRSRHG LGFLCCFGGS DLPEINLRDS HPLQYMEFSS PIPNPEELNI RFAELVDELD
LTDKNREAVF ALPPEKKWQI YCSKKKEQED PNKLATSWPD YYIDRINSMA AMQSLYAFDE
EETEMRNQVV EDLKTALRTQ PMRFVTRFIE LEGLTCLLNF LRSMDHATCE SRIHTSLIGC
IKALMNNSQG RAHVLAQPEA ISTIAQSLRT ENSKTKVAVL EILGAVCLVP GGHKKVLQAM
LHYQVYAAER TRFQTLLNEL DRSLGRYRDE VNLKTAIMSF INAVLNAGAG EDNLEFRLHL
RYEFLMLGIQ PVIDKLRQHE NAILDKHLDF FEMVRNEDDL ELARRFDMVH IDTKSASQMF
DLIHKKLKHT EAYPCLLSVL HHCLQMPYKR NGGYFQQWQL LDRILQQIVL QDERGVDPDQ
APLENFNVKN IVNMLINENE VKQWRDQAEK FRKEHAELVS RLERKERECE TKTLEKEEMM
RTLNKMKDKL ARESQELRQA RGQVAELVAQ LSEISTGPVS SPPPPGGPLT LSSSMTTNDL
PPPPPPLPFA CCPPPPPPPL PPGGPLTPPG APPCFSMGMP LPPDPFPSSD VPLRKKCVPQ
PSHPLKSFNW VKLNEVSNKR SSCSFLFFLP LTPGAFPGWH WGGSWAGVGG GQEEDWGKHT
PHPCHLACRL QKELGSTEDI HLASRKVKEL SVIDGRRAQN CIILLSKLKL SNEEIRQAIL
KMDEQEDLAK DMLEQLLKFI PEKSDVDLLE EHKHEIERMA RADRFLYEMS RIDHYQQRLQ
ALFFKKKFQE RLAEAKPKVE AILLASRELI RSKRLARMLE VVLAIGNFMN KGQRGGAYGF
RVASLNKIAD TKSSIDRNIS LLHYLIMILE KHFPDILNMP SELQHLPEAA KVNLAELEKE
VGNLRRGLRA VEVELEYQKR QVRDPNDKFV PVMSDFITVS SFSFSELEDQ LNEARAKFSK
ALTHFGEQDS KMQPDEFFGI FDAFLQAFSE ARQDLEAMRR RKEEEERRAR MEAMLKEQRE
RERWQRQRKV HAGSALEEGG EFDDLVSALR SGEVFDKDLC KLKRSRKRSG SQALEATRER
AINRLNY
//