ID A0A452EMJ1_CAPHI Unreviewed; 1379 AA.
AC A0A452EMJ1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=FERM and PDZ domain containing 2 {ECO:0000313|Ensembl:ENSCHIP00000013124.1};
GN Name=FRMPD2 {ECO:0000313|Ensembl:ENSCHIP00000013124.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000013124.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000013124.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000013124.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9925.ENSCHIP00000013124; -.
DR Ensembl; ENSCHIT00000020914.1; ENSCHIP00000013124.1; ENSCHIG00000014602.1.
DR GeneTree; ENSGT00940000161964; -.
DR Proteomes; UP000291000; Chromosome 28.
DR Bgee; ENSCHIG00000014602; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0005923; C:bicellular tight junction; IEA:Ensembl.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:Ensembl.
DR GO; GO:0070830; P:bicellular tight junction assembly; IEA:Ensembl.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011019; KIND_dom.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46900:SF3; FERM AND PDZ DOMAIN-CONTAINING 2; 1.
DR PANTHER; PTHR46900; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00595; PDZ; 3.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00750; KIND; 1.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51377; KIND; 1.
DR PROSITE; PS50106; PDZ; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 7..189
FT /note="KIND"
FT /evidence="ECO:0000259|PROSITE:PS51377"
FT DOMAIN 332..633
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 763..849
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 938..1023
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1067..1155
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 255..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1185..1240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1284..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 851..882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1379 AA; 150906 MW; 4593CFCAF001AE76 CRC64;
MWHPASVTLA SALQVRGEAL SEEEIWSLLS LAAERLLEDL CDDSSNYVVC PWSVLLSPTG
SLSFQDHVSH IEAAPFKAPE LLQGQSGDEQ HDASQMHVYS LGLTLYWSAG FHVPPNQPLQ
LCQPLHSILL TMCEDQPGRR LPLQSVLEAC QIHWEEAAVH PTSANLHVRQ LVGLVLGTIS
EVERRAVEES SSGQRDRSHL LRNRLHRASC ESQAAWALGC PRHCRVSERS TETQSSLEPG
LNTSAHGRCS VAVNSALPTQ DPPDLQEGRR LSSGSALPEN SRPATPSQRS FLQRKGKFSR
PEFALMAGEA PVTLYLPGSI VTKKAKSYLA LRGLCVVLLS GQCLEVKCDV TSTVGAVFSA
IAPFASLGEL TYFGLAYLKG KEFFFLDAET RLCKIAPEGW SEQPQKKSSP NTFVLFLRIK
FFVSHYGLLQ HSWTRHQFYL QLRKDILEEK LYCNDETLLQ LGVLALQAEF GSYPEEQVES
KAYFRVEDYV PASLIERMTA LRVQVEVSEM HRLSPVLWGE DAELEFLRVA QQLPEYGVLV
YQVLPEKTRL EGEMALGICA KGVIVYEVRN NSRIATSRFQ WREIEKILAY RKKFIITSSV
TGKKHVFVAD SVKTCKYLLG LCCAQHGFNA QMSSPGVTSD SNKCVQMGSL SLAHLPQSNQ
LTWIQRLSCS ENALFIPGLE DAAGGLLRRS LDNFTMDTSK GTGAQGLRGS PCLGREQLER
LCLIQKPTTC DPLSRQPAQS TRTGSRNNRR RSFIAEPDGE IVHVTLSRDP HRGFGFVINE
GEDVGKVDPG IFISSIIPGG PAEKAKKIKP GGQILALNHI SLEGFTFDMA VRMIQNSPDT
IELIISQSKG VCGNTSSEEK NSAANSGVFS TDSLSDGPRG SFSSHTQDRE RNIEELEVAQ
TQSVMPRLRP QLSALPFKGA GSFCPPSPSE TTASEIYFVE LVKEDGTLGF SVTGGINTSV
FCGGIYVKSI VPGGPAAKEG RILQGDRLLQ VDGVSLCGLT HKQAVQCLKG SGQVARLVLE
RRGPRIAQQC PSANDRMGEE CTAVSLATVS PGRPASSVSA TDGPKFEVKL KKNASGLGFS
FVQMESEHCG HLKNGLVMVK RLFPGQPAEE NGAIAVGDII LAVNGRSTEG LDFQEVLHLL
RGASQQVTLL LCRPPPGALP EMDQGWQTPV LVEDKEFPRA ACADLEQSPS LDQGDSRRDS
ASPDTGEGLG LRPESFQQAT QEAQRDQDTE RPWATSLTDP RDSFPHLCRL HQEMEASALA
TSLEKDLRQN CDSVCDIGRL GSPELYSDNE ERDMHHPPGT LSPTSEDGVY LTINPSLGDR
LPCGECLEAG SGTIPLPQFC FWGSFSQSLP PGSDSEWEDI EEAEDTDDGP LRWVALWVE
//
