ID A0A452ENR0_CAPHI Unreviewed; 184 AA.
AC A0A452ENR0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=P53 apoptosis effector related to PMP22 {ECO:0000313|Ensembl:ENSCHIP00000013759.1};
GN Name=PERP {ECO:0000313|Ensembl:ENSCHIP00000013759.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000013759.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000013759.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000013759.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM47 family.
CC {ECO:0000256|ARBA:ARBA00008691}.
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DR EMBL; LWLT01000012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005684867.1; XM_005684810.3.
DR AlphaFoldDB; A0A452ENR0; -.
DR STRING; 9925.ENSCHIP00000013759; -.
DR Ensembl; ENSCHIT00000021552.1; ENSCHIP00000013759.1; ENSCHIG00000015047.1.
DR GeneID; 102183420; -.
DR KEGG; chx:102183420; -.
DR CTD; 64065; -.
DR GeneTree; ENSGT00530000063484; -.
DR OMA; ASMWEQC; -.
DR OrthoDB; 4571618at2759; -.
DR Proteomes; UP000291000; Chromosome 9.
DR Bgee; ENSCHIG00000015047; Expressed in skin of neck and 18 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0097186; P:amelogenesis; IEA:Ensembl.
DR GO; GO:0002934; P:desmosome organization; IEA:Ensembl.
DR GO; GO:0034113; P:heterotypic cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0045862; P:positive regulation of proteolysis; IEA:Ensembl.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR015664; P53_induced.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR14399:SF4; P53 APOPTOSIS EFFECTOR RELATED TO PMP-22; 1.
DR PANTHER; PTHR14399; P53-INDUCED PROTEIN RELATED; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 184 AA; 20656 MW; 4CF3200C09961704 CRC64;
MLRCGLACER CRWILPLLLL SAIVFDIIAL AGRGWLQSSD DSQTSSLWWH CLQEVCDSLM
TYAWGRAAAA MLLCGFIILV ICFILSFFAL CGPQMLVFLR VIGGLLALAA VFQIISLVIY
PVKYTQTFNL HLNPAVTYIY NWAYGFGWAA TIILIGCAFF FCCLPNYEDD LLGNAKPRYF
YTSA
//
