ID A0A452EQT8_CAPHI Unreviewed; 671 AA.
AC A0A452EQT8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=HPS1 biogenesis of lysosomal organelles complex 3 subunit 1 {ECO:0000313|Ensembl:ENSCHIP00000014450.1};
GN Name=HPS1 {ECO:0000313|Ensembl:ENSCHIP00000014450.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000014450.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000014450.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000014450.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452EQT8; -.
DR Ensembl; ENSCHIT00000022245.1; ENSCHIP00000014450.1; ENSCHIG00000015465.1.
DR GeneTree; ENSGT00390000015298; -.
DR OMA; GLVHFMY; -.
DR Proteomes; UP000291000; Chromosome 26.
DR Bgee; ENSCHIG00000015465; Expressed in thymus and 18 other cell types or tissues.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR InterPro; IPR026053; HPS1.
DR PANTHER; PTHR12761:SF1; HERMANSKY-PUDLAK SYNDROME 1 PROTEIN; 1.
DR PANTHER; PTHR12761; HERMANSKY-PUDLAK SYNDROME PROTEIN 1; 1.
DR Pfam; PF19036; Fuz_longin_1; 1.
DR Pfam; PF19037; Fuz_longin_2; 1.
DR Pfam; PF19038; Fuz_longin_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 2..159
FT /note="FUZ/MON1/HPS1 first Longin"
FT /evidence="ECO:0000259|Pfam:PF19036"
FT DOMAIN 205..370
FT /note="FUZ/MON1/HPS1 second Longin"
FT /evidence="ECO:0000259|Pfam:PF19037"
FT DOMAIN 511..663
FT /note="FUZ/MON1/HPS1 third Longin"
FT /evidence="ECO:0000259|Pfam:PF19038"
FT REGION 248..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 671 AA; 75647 MW; 381B842C6B8227E6 CRC64;
MKCVLVATEG AEVLFYWTDA EFEESLRLKF GQTENEGEKP PALEDQLSTL LAPVIISSMT
MLEKLSDTYT CFSTENGNYL YVLHLFGECL FIAINGDRTE GEGDLRQKLC VLKYLFEVHF
GLVTVDGQLI RKELRPPDLE QRVQVWERFQ SLLWTYSRLR DQEQCFAVEA VERLIHPQLC
ELCIEALERH VIHAVNSSPG RAGEEALHAF LLVHSKLLAF YSSHSASSLR PADLLALILL
VQDLYPSEST AEDSDPQETD SFSPTDEYFT PAPSPGEQSS GSTIWLDGGT PPTDSPHIQM
AEDTLQMLIP HSPGPSGPRR IFLDASVKDS YCPLVPHTMY CLPLWPGISM VLLTKCPSTA
LALALYQLLD GFSQLEKKLK EGQEAGSSLR SHPIVADLRQ RMDKFVKNRG GQELQRTWQE
FKTKAFSKSE PGSSWELLQA CRKVKRQLCA IYRFSFLTVA PGRGGPHLPQ HLQDQVQTLM
QEKLADWKDF LLVKSRRNVT MPLTFLEDFP GLVHFIYVDR TTGQMVAPSL SSSESTSSEL
GRGPLATFVK TKVWSLIRLA RRYLQKGYTT LLFREGDFCC SYFLWFENDM GHKLQIMEVP
VLSDDSAPIG MLGGDYYRKL LRYYSKGHPA EAVRCHELLA LHLSVVPTDV LVQQAGELAR
RLGEASRLPL L
//
