ID   A0A452ERD0_CAPHI        Unreviewed;       428 AA.
AC   A0A452ERD0;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Xaa-Arg dipeptidase {ECO:0000256|PIRNR:PIRNR037226};
GN   Name=PM20D2 {ECO:0000313|Ensembl:ENSCHIP00000014645.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000014645.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Ensembl:ENSCHIP00000014645.1, ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000014645.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Catalyzes the peptide bond hydrolysis in dipeptides having
CC       basic amino acids lysine, ornithine or arginine at C-terminus.
CC       {ECO:0000256|PIRNR:PIRNR037226}.
CC   -!- SIMILARITY: Belongs to the peptidase M20A family.
CC       {ECO:0000256|PIRNR:PIRNR037226}.
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DR   EMBL; LWLT01000012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005684875.3; XM_005684818.3.
DR   AlphaFoldDB; A0A452ERD0; -.
DR   STRING; 9925.ENSCHIP00000014645; -.
DR   Ensembl; ENSCHIT00000022444.1; ENSCHIP00000014645.1; ENSCHIG00000015593.1.
DR   GeneID; 102187770; -.
DR   KEGG; chx:102187770; -.
DR   CTD; 135293; -.
DR   GeneTree; ENSGT00390000003365; -.
DR   OMA; HRSCAKT; -.
DR   OrthoDB; 1074531at2759; -.
DR   Proteomes; UP000291000; Chromosome 9.
DR   Bgee; ENSCHIG00000015593; Expressed in adult mammalian kidney and 17 other cell types or tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016805; F:dipeptidase activity; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0051246; P:regulation of protein metabolic process; IEA:Ensembl.
DR   CDD; cd05672; M20_ACY1L2-like; 1.
DR   Gene3D; 3.30.70.360; -; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR017439; Amidohydrolase.
DR   InterPro; IPR036264; Bact_exopeptidase_dim_dom.
DR   InterPro; IPR002933; Peptidase_M20.
DR   InterPro; IPR011650; Peptidase_M20_dimer.
DR   InterPro; IPR017144; Xaa-Arg_dipeptidase.
DR   NCBIfam; TIGR01891; amidohydrolases; 1.
DR   PANTHER; PTHR30575; PEPTIDASE M20; 1.
DR   PANTHER; PTHR30575:SF0; XAA-ARG DIPEPTIDASE; 1.
DR   Pfam; PF07687; M20_dimer; 1.
DR   Pfam; PF01546; Peptidase_M20; 1.
DR   PIRSF; PIRSF037226; Amidohydrolase_ACY1L2_prd; 1.
DR   SUPFAM; SSF55031; Bacterial exopeptidase dimerisation domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|PIRNR:PIRNR037226};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR037226};
KW   Protease {ECO:0000256|PIRNR:PIRNR037226};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT   DOMAIN          203..295
FT                   /note="Peptidase M20 dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF07687"
SQ   SEQUENCE   428 AA;  46589 MW;  19211DC0829773CE CRC64;
     MRPGEERPVE GGACASVSDL ELLKLRAAEC IDAAAERLGA LSRSIWSEPE LAYEEHHAHG
     VLTRFFQSET PAGSWTVQPH YQLATAFRAE WGSPRGWAAP RPLHLGFLCE YDALPGIGHA
     CGHNLIAEVG AAAALGVKGA LESLAGLPLP LKVIVLGTPA EEDGGGKIDL IEAGAFKNLD
     VVFMAHPSQE NAAYLPDVAE HDVTVKYYGK ASHAAAYPWE GLNALDAAVL AYNNLSVLRQ
     QLKPTWRVHG IIKNGGVKPN IIPSYSELIY YFRAPSMKEL PVLTKKAEDC FRAAALATGC
     TVEINGGAHD YYNVLPNKSL WKTYVENGKK LGIDFISEDA MFSGPSGSTD FGNVSFVVPG
     IHPYFYIGSN ALNHTEQYTE AAGSQEAQFY TLRTAKALAM TALDVIFKPE LLERIREDFK
     LKLQEEQF
//