ID A0A452ERI0_CAPHI Unreviewed; 1293 AA.
AC A0A452ERI0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Transcriptional repressor GATA binding 1 {ECO:0000313|Ensembl:ENSCHIP00000014463.1};
GN Name=TRPS1 {ECO:0000313|Ensembl:ENSCHIP00000014463.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000014463.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000014463.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000014463.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017913851.1; XM_018058362.1.
DR STRING; 9925.ENSCHIP00000014463; -.
DR Ensembl; ENSCHIT00000022259.1; ENSCHIP00000014463.1; ENSCHIG00000015490.1.
DR GeneID; 102184827; -.
DR KEGG; chx:102184827; -.
DR CTD; 7227; -.
DR GeneTree; ENSGT00940000157893; -.
DR OrthoDB; 2948149at2759; -.
DR Proteomes; UP000291000; Chromosome 14.
DR Bgee; ENSCHIG00000015490; Expressed in thymus and 16 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR CDD; cd00202; ZnF_GATA; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR InterPro; IPR028440; TRPS1.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR47034; ZINC FINGER TRANSCRIPTION FACTOR TRPS1; 1.
DR PANTHER; PTHR47034:SF1; ZINC FINGER TRANSCRIPTION FACTOR TRPS1; 1.
DR Pfam; PF00320; GATA; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SMART; SM00401; ZnF_GATA; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 704..732
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 902..960
FT /note="GATA-type"
FT /evidence="ECO:0000259|PROSITE:PS50114"
FT REGION 1..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1051..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1180..1205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..524
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1005
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1051..1073
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1293 AA; 142307 MW; 755F247A838A2EDE CRC64;
MPYEVNAGYD FTNMVRKKNP PLRNIASEGE GQTLEPVGTE SKGPGKNKEF SADQMSENTD
QSDATELNNK EEHSLHVQNP SSSSKKDLKS SVLSEKAGFN YESPSKGGNL PSYSHDEVTE
RNMLAFSSPA AGGVCEPLKS PQRAEADDPQ DMACTPSGDS LEMKEDQKMS PKATEETGQA
QSGQANCQGS SPVSVASKNP QVPSDGGVRL NKSKTDVLVN DNPDPAPLSP ELQDFKCNIC
GYGYYGNDPT DLIKHFRKYH LGLHNRTRQD AELDSKILAL HNMVQFSHSK DFQKVNRSVL
SGVLQDISSS RPVLLNGTYD VQVTSGGTFI GIGRKTPDCQ GNTKYFRCKF CNFTYMGNSS
TELEQHFLQT HPNKIKASLP SSEGPKSSEK NSNKSIPAVR SGDAGDLGKW QDKITVKAVD
DTPVGYSVPI KPLDSRQNGT EATSYYWCKF CSFSCESSSS LKLLEHYGKQ HGGAQSGGLN
PELNDKLSRG SVINQNDLAK SAEGEPMTKA DKGSGGVKKK DFSSKGAEDN MVTSYNCQFC
DFRYSKSHGP DVIVVGPLLR HYQQLHNIHK CTIKHCPFCP RGLCSPEKHL GEITYPFACR
KSNCSHCALL LLHLSPGAAG SSRVKHQCHQ CSFSTPDVDV LLFHYESAHE SQASDVKQEG
SHLQGPDGQP AVKESKEHSC TKCDFITQVE EEISRHYRRA HSCYKCRQCS FTAAETQSLL
EHFNTVHCQE QDSTTANGEE DGHAVSTIKE EPKIDLKVYS LLNPDSKMGE PVAESVVKRE
KLEDKDGLKE KAWAESSSDD LRSVTWRGAD ILRGSPSYTQ ASLGLLTPVS GPQEQTKTLR
DSPNVEAAHL ARPIYGLAVD TKGFLQGAPA GGEKAGALPQ QYPASGESKS KDESQSLLRR
RRGSGVFCAN CLTTKTSLWR KNANGGYVCN ACGLYQKLHS TPRPLNIIKQ NNGEQIIRRR
TRKRLNPEAL QAEQLNKQQR AGSEEQVNGS PLERRSEDHL TEGHQREIPL PSLSKYEAQG
SLTKSHSAQQ PVLVSQTLDI HKRMQPLHIQ IKSPQESTGD PGNSSSVSEG KGSSERGSPI
EKYMRPAKHP NYSPPGSPIE KYQYPLFGLP FVHNDFQSEA DWLRFWSKYK LSVPGNPHYL
SHVPGLPNPC QNYVPYPTFN LPPHFSAVGS DNDIPLDLAI KHSRPGPTAN GASKEKTKAP
SNVKNERPLN VVKTEKVDRS TQDELSTKCV HCGIVFLDEV MYALHMSCHG DSGPFQCSIC
QHLCTDKYDF TTHIQRGLHR NNAQVEKNGK PKE
//
