ID A0A452ERN1_CAPHI Unreviewed; 626 AA.
AC A0A452ERN1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Phosphatidylinositol binding clathrin assembly protein {ECO:0000313|Ensembl:ENSCHIP00000014750.1};
GN Name=PICALM {ECO:0000313|Ensembl:ENSCHIP00000014750.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000014750.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000014750.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000014750.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PICALM/SNAP91 family.
CC {ECO:0000256|ARBA:ARBA00008011}.
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DR EMBL; LWLT01000026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452ERN1; -.
DR SMR; A0A452ERN1; -.
DR Ensembl; ENSCHIT00000022549.1; ENSCHIP00000014750.1; ENSCHIG00000015634.1.
DR GeneTree; ENSGT00950000183068; -.
DR Proteomes; UP000291000; Chromosome 29.
DR Bgee; ENSCHIG00000015634; Expressed in metanephros cortex and 16 other cell types or tissues.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:InterPro.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR CDD; cd16985; ANTH_N_AP180; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 1.20.58.150; ANTH domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR014712; ANTH_dom_sf.
DR InterPro; IPR045192; AP180-like.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR PANTHER; PTHR22951; CLATHRIN ASSEMBLY PROTEIN; 1.
DR PANTHER; PTHR22951:SF16; PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN; 1.
DR Pfam; PF07651; ANTH; 1.
DR SMART; SM00273; ENTH; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50942; ENTH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 1..111
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT REGION 525..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 287..314
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 626 AA; 68211 MW; 8516F4C7FDD16F90 CRC64;
MGPKKKHLDY LIQCTNEMNV NIPQLADSLF ERTTNSSWVV VFKSLITTHH LMVYGNERFI
QYLASRNTLF NLSNFLDKSG LQGYDMSTFI RRYSRYLNEK AVSYRQVAFD FTKVKRGADG
VMRTMNTEKL LKTVPIIQNQ MDALLDFNVN SNELTNGVIN AAFMLLFKDA IRLFAAYNEG
IINLLEKYFD MKKNQCKEGL DIYKKFLTRM TRISEFLKVA EQVGIDRGDI PDLSQAPSSL
LDALEQHLAS LEGKKIKDST AASRATTLSN AVSSLASTGL SLTKVDEREK QAALEEEQAR
LKALKEQRLK ELAKKPHTSL TTAASPVSTS AGSVMTAPAI DIFSTPSSSN STSKLPNDLL
DLQQPTFHPS VLSMSTASQV ASTWGDPFSA TVDAVDDAIP SLNPFLTKSS GDVHLPISSD
VSTFTTRTPT HEMFVGFTPS PVAQPHPSAG LNVDFESVFG NKSTNITVDS GGFDELGGLL
KPTVASQNQS LPVAKLPPNK LVSDDLDSSL ANLVGNLGIG NGTTKNDVNW SQPGEKKLTG
GSNWQPKVAP TTAWNAATMN GMHFPQYAPP VMAYPATTPT GMIGYGIPPQ MGSVPVMTQP
SLIYSQPVMR PPNPFGPVSG AQIQFM
//
