ID A0A452ERR7_CAPHI Unreviewed; 1077 AA.
AC A0A452ERR7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=USP25 {ECO:0000313|Ensembl:ENSCHIP00000014877.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000014877.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000014877.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000014877.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR EMBL; LWLT01000001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452ERR7; -.
DR Ensembl; ENSCHIT00000022676.1; ENSCHIP00000014877.1; ENSCHIG00000015678.1.
DR GeneTree; ENSGT00940000157962; -.
DR Proteomes; UP000291000; Chromosome 1.
DR Bgee; ENSCHIG00000015678; Expressed in longissimus thoracis muscle and 16 other cell types or tissues.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR CDD; cd02665; Peptidase_C19I; 1.
DR CDD; cd14354; UBA_UBP25; 1.
DR CDD; cd20486; USP25_C; 1.
DR Gene3D; 6.10.250.1720; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR044635; UBP14-like.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR43982; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR43982:SF6; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF02809; UIM; 2.
DR SMART; SM00726; UIM; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 192..680
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 487..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 709..736
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 495..529
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1077 AA; 125054 MW; 58F79B5A0DA7DB7D CRC64;
MAKKLKMFPE HQQTFLNQLR EITGINDAQI LQQALKDSNG NLELAVAFLT AKNAKTPQQE
ETTYYQTALP GNDRYISVGS QADTRKKQYM PTRTRCATIE QSKYGSKDKR DLDVIDLTGD
DKDDLQRAIA LSLAESNRAF RETGITDEEQ AISRVLEASI AENKECLKRT PTEVWRDSRN
PYDRKRQDKA PVGLKNVGNT CWFSAVIQSL FNLLEFRRLV LNYKPPSNVQ DLPRNQKEHR
NLPFMRELRY LFALLVGTKR KYVDPSRAVE ILKDAFKSND SQQQDVSEFT HKLLDWLEDA
FQMKAEEETD EDKPKNPMVE LFYGRFLAVG VLEGKKFENT EMFGQYPLQV NGFKDLHECL
EAAMIEGEIE SLHSENSGKS GQEHWFTELP PVLTFELSRF EFNQALGRPE KIHNKLEFPQ
VLYLDRYMHR NREITRIKRE EIKRLKDYLT VLQQRLERYL SYGSGPKRFP LVDVLQYALE
FASSKPVCTS PVDDIDASSP PSGSVPSQTL PSTTDQQGAP SSELPSTSPA SIAAISSRSV
IHKPFTQSRI PPDLPMHPAP RHITEEELSV LESCLHRWRT EIENDTRDLQ ESISRIHRTI
DLMYSDKSMI QVPYRLHAVL VHEGQANAGH YWAYIFDHRE NRWMKYNDIA VTKSSWEELV
RDSFGGYRNA SAYCLMYIND KPQFLIQEEF NKETGQALAG IETLPPDLRD FVEEDNQRFE
KELEEWDAQL AQKALQEKLL ASQKLRESES SVTTAQAGEP EYLEQPSRSD FSKHLKEETI
RIITKASHEH EDKSPETVLQ SAIKLEYSRL VKLAQEDTPP ETDYRLHHVI VYFIQNQAPK
KIIEKTLLEQ FADRNLSFDE RCHNIMKVAQ AKIEMIKPEE VNMEEYEEWH QDYRKFRETT
MYLIIGLENF QRESYIDSLL FLICAYQNNK ELLSKGPYRG HDEELISHYR RECLLKLNEQ
AAELFESGED REVNNGLIIM NEFIVPFLPL LLVDEMEEKD ILAVEDMRNR WCSYLGQEME
SNLQEKLTDF LPKLLDCSTE VKGFHEPPKL PPYSTHELCE RFTRIMLSLS RTPADGR
//