ID A0A452ERW3_CAPHI Unreviewed; 1152 AA.
AC A0A452ERW3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Ubiquitin specific peptidase 25 {ECO:0000313|Ensembl:ENSCHIP00000014840.1};
GN Name=USP25 {ECO:0000313|Ensembl:ENSCHIP00000014840.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000014840.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000014840.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000014840.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017907986.1; XM_018052497.1.
DR AlphaFoldDB; A0A452ERW3; -.
DR STRING; 9925.ENSCHIP00000014840; -.
DR Ensembl; ENSCHIT00000022639.1; ENSCHIP00000014840.1; ENSCHIG00000015678.1.
DR GeneID; 102177278; -.
DR CTD; 29761; -.
DR GeneTree; ENSGT00940000157962; -.
DR OrthoDB; 1423057at2759; -.
DR Proteomes; UP000291000; Chromosome 1.
DR Bgee; ENSCHIG00000015678; Expressed in longissimus thoracis muscle and 16 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:Ensembl.
DR GO; GO:0032183; F:SUMO binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:1904293; P:negative regulation of ERAD pathway; IEA:Ensembl.
DR CDD; cd02665; Peptidase_C19I; 1.
DR CDD; cd14354; UBA_UBP25; 1.
DR CDD; cd20486; USP25_C; 1.
DR Gene3D; 6.10.250.1720; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF666; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 25; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF02809; UIM; 2.
DR SMART; SM00726; UIM; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 197..685
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 492..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 714..741
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 500..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1152 AA; 133252 MW; CC82809C23D9B884 CRC64;
MTVEQNVLQQ SAAQKHQQTF LNQLREITGI NDAQILQQAL KDSNGNLELA VAFLTAKNAK
TPQQEETTYY QTALPGNDRY ISVGSQADTR KKQYMPTRTR CATIEQSKYG SKDKRDLDVI
DLTGDDKDDL QRAIALSLAE SNRAFRETGI TDEEQAISRV LEASIAENKE CLKRTPTEVW
RDSRNPYDRK RQDKAPVGLK NVGNTCWFSA VIQSLFNLLE FRRLVLNYKP PSNVQDLPRN
QKEHRNLPFM RELRYLFALL VGTKRKYVDP SRAVEILKDA FKSNDSQQQD VSEFTHKLLD
WLEDAFQMKA EEETDEDKPK NPMVELFYGR FLAVGVLEGK KFENTEMFGQ YPLQVNGFKD
LHECLEAAMI EGEIESLHSE NSGKSGQEHW FTELPPVLTF ELSRFEFNQA LGRPEKIHNK
LEFPQVLYLD RYMHRNREIT RIKREEIKRL KDYLTVLQQR LERYLSYGSG PKRFPLVDVL
QYALEFASSK PVCTSPVDDI DASSPPSGSV PSQTLPSTTD QQGAPSSELP STSPASIAAI
SSRSVIHKPF TQSRIPPDLP MHPAPRHITE EELSVLESCL HRWRTEIEND TRDLQESISR
IHRTIDLMYS DKSMIQVPYR LHAVLVHEGQ ANAGHYWAYI FDHRENRWMK YNDIAVTKSS
WEELVRDSFG GYRNASAYCL MYINDKPQFL IQEEFNKETG QALAGIETLP PDLRDFVEED
NQRFEKELEE WDAQLAQKAL QEKLLASQKL RESESSVTTA QAGEPEYLEQ PSRSDFSKHL
KEETIRIITK ASHEHEDKSP ETVLQSKPEN TTSQPPSKQQ VVEVEIPHVG TFMIESKEGG
YDDEIMMTPN MQGIIMAIGK SRSVYDRCGP EAGFFKAIKL EYSRLVKLAQ EDTPPETDYR
LHHVIVYFIQ NQAPKKIIEK TLLEQFADRN LSFDERCHNI MKVAQAKIEM IKPEEVNMEE
YEEWHQDYRK FRETTMYLII GLENFQRESY IDSLLFLICA YQNNKELLSK GPYRGHDEEL
ISHYRRECLL KLNEQAAELF ESGEDREVNN GLIIMNEFIV PFLPLLLVDE MEEKDILAVE
DMRNRWCSYL GQEMESNLQE KLTDFLPKLL DCSTEVKGFH EPPKLPPYST HELCERFTRI
MLSLSRTPAD GR
//
