ID   A0A452ESJ7_CAPHI        Unreviewed;      1037 AA.
AC   A0A452ESJ7;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=GTPase activating Rap/RanGAP domain like 3 {ECO:0000313|Ensembl:ENSCHIP00000015149.1};
GN   Name=GARNL3 {ECO:0000313|Ensembl:ENSCHIP00000015149.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000015149.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Ensembl:ENSCHIP00000015149.1, ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000015149.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   EMBL; LWLT01000009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A452ESJ7; -.
DR   STRING; 9925.ENSCHIP00000015149; -.
DR   Ensembl; ENSCHIT00000022951.1; ENSCHIP00000015149.1; ENSCHIG00000015896.1.
DR   GeneTree; ENSGT00940000159362; -.
DR   OMA; FEGYSER; -.
DR   Proteomes; UP000291000; Chromosome 11.
DR   Bgee; ENSCHIG00000015896; Expressed in cerebellum and 14 other cell types or tissues.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   PANTHER; PTHR15711:SF62; GTPASE-ACTIVATING RAP_RAN-GAP DOMAIN-LIKE PROTEIN 3; 1.
DR   PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50219; CNH; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW   ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT   DOMAIN          213..429
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   DOMAIN          511..822
FT                   /note="CNH"
FT                   /evidence="ECO:0000259|PROSITE:PS50219"
FT   REGION          832..861
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          935..1023
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        832..851
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        935..964
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        968..1009
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1037 AA;  115387 MW;  2E784CADCBAA4896 CRC64;
     MDPLTKGPCG NQMAQTLMWK AKSSLSFGIQ PLQTWPTKDP EVEAQVNLSV SEDLGCRRGD
     FSRKHYGSVE LLISSDADGA IQRAGRFRVE NGSSDENATA LPGTWRRTDV HLENPEYHTR
     WYFKYFLGQV HQNYIGNDAE KSPFFLSVTL SDQNNQRVPQ YRAILWRKTG TQKICLPYSP
     TKTLSVKSIL SAMNLDKFEK GPREIFHPEI QKCLLLSHCK GSVNFKFGVL FAKDGQLTDD
     DMFSNEIGSD AFQKFLNLLG DTITLKGWTG YRGGLDTKND TTGIHSVYTI YQGHEIMFHV
     STMLPYSKEN KQQVERKRHI GNDIVTIVFQ EGEEPSPAFK PSMIRSHFTH IFALVRYDQQ
     KDNYRLKIFS EESVPLFGPP LPSPPVFTDH QEFRDFLLVK LINGEKATLE TPTFAQKRRR
     TLDMLIRSLY QDLMPDVHKN MLNRRSFSDV LPESPKSARK KEEARQAEFV RIGQALKLKS
     IVRGDAPSSL VASGICKKEP WEPQCFCSNF PHEAVCADPW GQALLVSTDA GVLLVDDDLP
     SVPVFDKTLP VKQMHVLEAL DLLILRADKG KDARLFVFRL SAVQRGIEGK QAVKGKCDCR
     ENKLEKTKGC HLYAINTHHS RELRIVVAIR NKLLLITRKH NKPSGVTGMS LLSPLSESPV
     EEFQYIREIC LSDSPAVMTL VDGPTEESDN LICVAYRHQF DVVNESTGEA FRLHHVEASR
     VNFVAAIDVY EDGEAGLLLC YNYSCIYKKV CPFNGGSFLV QPSASDFQFC WNQAPCAIVC
     AFPYLLAFTT DSMEIRLVVN GNLVHTAVVP QLQLVASRSD IYFTATASAN EVSSGGSSKG
     ASAHNSPQTP PGRDTPVFPS SLGEGEIQSK NLYKIPLRNL VGRSIERPLK SPLVSKVITP
     PTSIGIGIAA IPVTHSLSLS RMEIKEIASR TRRELLGLSD DGGSRSEGAP KPKSKARKRL
     EENQGGPKPG TVRSTSSDRI TSSSLESPST SEANPNGRYQ STSSDPDPVA EQEGSPIWGS
     CPFQLTAFSD EDIIDLK
//