ID   A0A452ETY5_CAPHI        Unreviewed;       444 AA.
AC   A0A452ETY5;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Protein arginine methyltransferase 8 {ECO:0000313|Ensembl:ENSCHIP00000015196.1};
GN   Name=PRMT8 {ECO:0000313|Ensembl:ENSCHIP00000015196.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000015196.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Ensembl:ENSCHIP00000015196.1, ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000015196.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   EMBL; LWLT01000005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_017904110.1; XM_018048621.1.
DR   AlphaFoldDB; A0A452ETY5; -.
DR   STRING; 9925.ENSCHIP00000015196; -.
DR   Ensembl; ENSCHIT00000022998.1; ENSCHIP00000015196.1; ENSCHIG00000015940.1.
DR   GeneID; 102181847; -.
DR   CTD; 56341; -.
DR   GeneTree; ENSGT00940000155867; -.
DR   OMA; GFWDNVW; -.
DR   OrthoDB; 197898at2759; -.
DR   Proteomes; UP000291000; Chromosome 5.
DR   Bgee; ENSCHIG00000015940; Expressed in frontal cortex and 5 other cell types or tissues.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0140939; F:histone H4 methyltransferase activity; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0035242; F:protein-arginine omega-N asymmetric methyltransferase activity; IEA:Ensembl.
DR   GO; GO:0035241; F:protein-arginine omega-N monomethyltransferase activity; IEA:Ensembl.
DR   GO; GO:1904047; F:S-adenosyl-L-methionine binding; IEA:Ensembl.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR025799; Arg_MeTrfase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR11006; PROTEIN ARGININE N-METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR11006:SF47; PROTEIN ARGININE N-METHYLTRANSFERASE 8; 1.
DR   Pfam; PF06325; PrmA; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51678; SAM_MT_PRMT; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01015};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PROSITE-ProRule:PRU01015};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU01015}.
FT   REGION          70..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   444 AA;  50580 MW;  8BF8BA11710ADEA2 CRC64;
     MVPADAPAEG LGWAFFFFFP SHSLSFSLSF KATPALSFSH HGATKPSLAL MGMKHSSRCL
     LLRRKMAENA SESTEVSSPP SQPPQPVVPA KPVQCVHHVS TQPSCPGRGK MSKLLNPEEM
     TSRDYYFDSY AHFGIHEEML KDEVRTLTYR NSMYHNKHVF KDKVVLDVGS GTGILSMFAA
     KAGAKKVFGI ECSSISDYSE KIIKANHLDN IITIFKGKVE EVELPVEKVD IIISEWMGYC
     LFYESMLATV IFARDKWLKP GGLMFPDRAA LYVVAIEDRQ YKDFKIHWWE NVYGFDMTCI
     RDVAMKEPLV DIVDPKQVVT NACLIKEVDI YTVKTEELSF TSAFCLQVQR NDYVHALVTY
     FNIEFTKCHK KMGFSTAPDA PYTHWKQTVF YLEDYLTVRR GEEIYGTISM KPNAKNVRDL
     DFTVDLDFKG QLCETSVSNY YKMR
//