ID A0A452EUX7_CAPHI Unreviewed; 1327 AA.
AC A0A452EUX7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=PR/SET domain 15 {ECO:0000313|Ensembl:ENSCHIP00000015840.1};
GN Name=PRDM15 {ECO:0000313|Ensembl:ENSCHIP00000015840.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000015840.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000015840.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000015840.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LWLT01000001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9925.ENSCHIP00000015840; -.
DR Ensembl; ENSCHIT00000023645.1; ENSCHIP00000015840.1; ENSCHIG00000016222.1.
DR GeneTree; ENSGT00940000157890; -.
DR Proteomes; UP000291000; Chromosome 1.
DR Bgee; ENSCHIG00000016222; Expressed in thymus and 18 other cell types or tissues.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0043409; P:negative regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:2000035; P:regulation of stem cell division; IEA:Ensembl.
DR CDD; cd19199; PR-SET_PRDM15; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 11.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR044409; PRDM15_PR-SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24384; FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED; 1.
DR PANTHER; PTHR24384:SF193; PR_SET DOMAIN 15; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR Pfam; PF13894; zf-C2H2_4; 1.
DR Pfam; PF12874; zf-met; 1.
DR SMART; SM00355; ZnF_C2H2; 17.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 8.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 241..351
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 559..581
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 586..614
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 647..674
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 674..696
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 724..751
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 751..778
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 842..869
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 878..905
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 906..933
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 934..961
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 962..989
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 990..1017
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1018..1046
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 36..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1109..1140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1292..1327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1312
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1327 AA; 148788 MW; 371E709A3CD27260 CRC64;
RPPASGAAQF PERIATRSPD PIPLCTFQRQ VKPGPRARLA GCGHRGRSES KPGWISRSRS
GIALRAACPP VPRDVTLPRP RAQPQGASVL YSAHEIMCSA NLHFHLDFAL SAVHPLIAPG
DGNGAEGIWN QHSGSMPACM LPQNGCLFSG CEDCSQYHDS ECPELGPVVM VKDSFVLSRA
SYLYHPTQAR CLTHAWLGAG AVGSECRWPA PRSGAGTPWL CQPTFPWGRG TVSPVESSLP
SNLEIRRLED GAEGVFAVTQ LVKRTQFGPF ESRRVAKWEK ESAFPLKVFQ KDGHPVCFDT
SNEDDCNWMM LVRPAAEPGH QNLTAFQHGS DVYFTTSRDI PPGTELRVWY AAFYAKRMDK
PMLRQACPGL QAAGAPENST PVEAEPSQWA CKVCSATFLE LQLLNEHLLG HLEQSKSGAP
AGQQESAPEK EADVPRGEPA EVPKTVSATK EQKKKPRRGR KPKTSKPEQP LVIVEGKEPA
EQVTEIMTEV EPVTATPDER IMELVLGKLA ATPSDTSSVP KFPHHQSSTI TLKRSLILSS
RHGIRRKVVR QLGEHRRVYQ CSICSKVFQN SSNLSRHVRS HGDKLFKCEE CAKLFSRKES
LKQHVSYKHS RNEVDSEYRY RCGTCEKTFR IQSALEFHNC RTDDKTFQCE MCFRFFSTNS
NLSKHKKKHG DKKFACEVCN KMFYRKDVML DHQRRHLEGV RRVKREDVEA GGGENLVRYR
KEPSGCPVCG KVFSCRSNMN KHLLTHGDKK YTCEICGRKF FRVDVLRDHI HVHFKDIALM
DDHQREEFIG KIGISSEEND DHSDESADSE PHKYSCKRCQ LTFGRGKEYL KHIMEVHKEK
GYGCSICHRR FALKATYHAH MVIHRENLPD PNVQKYIHPC EICGRIFNSI GNLERHKLIH
TGVKSHACEQ CGKSFARKDM LKEHMRVHDN IREYLCAECG KGMKTKHALR HHMKLHKGIK
EYECRECHRK FAQKVNMLKH YKRHTGIKDF MCELCGKTFS ERNTMETHKL IHTVGKQWTC
SVCDKKYVTE YMLQKHVQLT HDKVEAQSCQ LCGTKVSTRA SMSRHMRRKH PEVLAVRIDD
LDHLPETTTI DASSIGIVQP ELSLEQEELA EGKHVKATRR APKRKQKPEE EAGATGPEDA
AFSEFSEKEG TFSGAVGDET DSAVQSIQQV VVTLGDPNVT TPSSSVGLTN ITVTPITTTA
GTQFTNLQPV AVGHLSTPER QLQLDNSILT VTFDTVSGSA MLHNRQNDLQ IHPQPEASNP
QSVAHFINLT TLVNSITPLG SQLGEQHPLT WRAVPQTDGP PPPPPAPAPQ AAQPSVPAEQ
QPQMYSY
//
