ID A0A452EW00_CAPHI Unreviewed; 8801 AA.
AC A0A452EW00;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Spectrin repeat containing nuclear envelope protein 1 {ECO:0000313|Ensembl:ENSCHIP00000016158.1};
GN Name=SYNE1 {ECO:0000313|Ensembl:ENSCHIP00000016158.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000016158.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000016158.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000016158.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus outer membrane
CC {ECO:0000256|ARBA:ARBA00004605}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004605}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004605}.
CC -!- SIMILARITY: Belongs to the nesprin family.
CC {ECO:0000256|ARBA:ARBA00008619}.
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DR EMBL; LWLT01000012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9925.ENSCHIP00000016158; -.
DR Ensembl; ENSCHIT00000023964.1; ENSCHIP00000016158.1; ENSCHIG00000016453.1.
DR GeneTree; ENSGT00940000154481; -.
DR OMA; PCAPEDF; -.
DR Proteomes; UP000291000; Chromosome 9.
DR Bgee; ENSCHIG00000016453; Expressed in cerebellum and 16 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0034993; C:meiotic nuclear membrane microtubule tethering complex; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000932; C:P-body; IEA:Ensembl.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:Ensembl.
DR GO; GO:0030017; C:sarcomere; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0140444; F:cytoskeleton-nuclear membrane anchor activity; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0005521; F:lamin binding; IEA:Ensembl.
DR GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR GO; GO:0042692; P:muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0090292; P:nuclear matrix anchoring at nuclear membrane; IEA:Ensembl.
DR CDD; cd21241; CH_SYNE1_rpt1; 1.
DR CDD; cd21243; CH_SYNE1_rpt2; 1.
DR CDD; cd00176; SPEC; 13.
DR Gene3D; 1.20.58.60; -; 34.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR039906; Anc-1/SYNE1/2-like.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR047290; CH_SYNE1_rpt1.
DR InterPro; IPR047291; CH_SYNE1_rpt2.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR21524:SF5; KLARSICHT PROTEIN; 1.
DR PANTHER; PTHR21524; SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF10541; KASH; 1.
DR Pfam; PF00435; Spectrin; 15.
DR SMART; SM00033; CH; 2.
DR SMART; SM01249; KASH; 1.
DR SMART; SM00150; SPEC; 41.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 47.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS51049; KASH; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT TOPO_DOM 1..8750
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT TOPO_DOM 8772..8801
FT /note="Perinuclear space"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT DOMAIN 24..131
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 175..280
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 8742..8801
FT /note="KASH"
FT /evidence="ECO:0000259|PROSITE:PS51049"
FT REGION 5864..5891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6197..6216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8247..8285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8675..8737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1404..1438
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1971..2025
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2228..2285
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3396..3423
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3741..3794
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4099..4157
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4266..4303
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4764..4798
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5059..5117
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5348..5375
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5497..5527
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5619..5646
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5738..5813
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6063..6090
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6232..6259
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6531..6558
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 7062..7089
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 7168..7198
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 7817..7844
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 5867..5891
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8251..8271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8675..8735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 8801 AA; 1010069 MW; 2519DB156C7857F4 CRC64;
SSSSHRFFIR IQRIILFLPD EQEIVQKRTF TKWINSHLAK RKPPMVVDDL FEDMKDGVKL
LALLEVLSGQ KLPCEQGRRM KRIHAVANIG TALKFLEGRK IKLVNINSTD IADGRPSIVL
GLMWTIILYF QIEELTSNLP QLQALSSSTS SVDSMVSSET ASPPSKRKVA TKIQGNAKKA
LLKWVQYTVT KQSGIEVKDF GRSWRSGVAF HSVIHAIRPE LVDLEKVKGR PNRENLEEAF
TIAETELGIP RLLDPEDVDV DKPDEKSIMT YVAQFLKQYP DVHSTGSDGQ EIDVSIFTNK
IVMSREDRLI LKEMKVWIEQ FERDLTRAQM TDSSLQDKYQ SFKHFRVQYE MKRKQIEHLL
QPLHRDGKLS LDQALVKQAW DRVSSRLFDW HIQLDKSLPA PLGTIGAWLY RAEVALREEI
TIQQVHEETA NTIQRKREQH KDLLQNTDAH KRAFHEIYRT RSVNGIPVPP DQLEDMAERF
HFVSSTSELH LMKMEFLELK YRLLSLLVLA ESKLKSWIIK YGGRDSVELL LQNYISFIEN
SKFFEQYEVT YQILKQTAEM YVKADGSVEE AENVMKFMNE TTAQWRNLSV EVRSVRSMLE
EVIANWDRYG NTVASLQAWL EDAEKMLNQS EHAKKDFFRN LPHWIQQHTA MNDAGNFLIE
TCDEMVSRDL KQQLLLLNGR WRELFMEVKQ YARADELDRM KKEYNDCVTV LSDFATEARR
KLSEPLEVSF INVKLLIQDL EDIEQRVPVM DAQYKMITKT AHLITKEISQ EEASEMFATM
SGLKEQLTKV KDCYSPLLSE SQQLLVPLEE LEKQMTAFYD SLGKIDEIMT VLEHEAQSSP
LFKQKHQELL ACQESCKKAM TQIEKGSQSV QKFVTLSNVL KHFDQTKLQR KIADMHVAFQ
NMVKKTGDWK KHVETNSRLM KKFEESRAEL EKVLRVAQEG LEEKGDPEDL LKRHTEFFSQ
LDQRVLNAFL KACDELTDIL PEQEQRGLQE AVRKLHKQWK DLQAEAPYHL LHLKIEVEKN
RFLASVEECR AELDRETKVC PRESRRPFKY ITDIFFSDKG PHHLCEKRLQ LIEELCLKLP
VRDAVRNTPE TCHVTLKELR AAIDCTYVKL VGDPDKWKDY TSRISEFSSW ISAKETQLKG
IKNETIDTAN QGEVKRALEE IRSGITKKGE TLSWLKSRLK ILIEVSSEDE AQKQGDELAK
LSSSFKALGT LLSEVEKMLS NFGDCVQYKE IVKSSLEELI TGSKEVQEEA EKILDTENLF
EAQQLLLRHQ QKTKRINAKK KDVQQQIAQA QQGEGGLPRR VQEELQKLES TLDSVEHSRE
KQERRIQVTL RKWERFETNK ETVVRYLFQT GSSHERFLSF SSLESLSSEL EQTKEFSKRT
EGIAVQAENL VKEASEIPLG PKNKQLLQQQ AKSIKEQVKK LEDTLEEDIK TMEMVKNKWD
HFGTNFETLS IWITEKEKEL NALETSSSAM DTQINQIKVM IKEIESKISS ITGLEEEAQS
FAQFITTGES ARIKAKLTQI RRYWEELREH AQSLQGIILG HLSQQQKFEE NLKKIQQSVS
EFEDKLADPV KICSSATETY KVLQEHMDLY QALESLTSTV AALSASARKV SNRDASIQEA
ATMQRSYEGL LGRAKERQTE LEKLLACWQR LEKELSTFLT WLERCEAIAS SPEANISADR
VKVESELQSI QVLQNEVVSQ ASIYSNLLQL KESLFSVASE DDVKMMKLQL EQLDERWRDL
PQIISKRINF LQSVVAEHQQ FDELLLSFSV WIKLFLSELQ TTSEISIVDH QAALTRHKDH
VAEVESKKGE LQSLQGHLAK LGALSRAEDL HLLQGKAEDC LQLFEEASQV VERRQHALSQ
LAKFLQSHAS LSESLHQLRQ TVEATHSMNK KQSDLLERDL NDAIRNVKTL ESAAISLDGL
LTKAQYHLKS GGSEQRTSCR ATSDHLSVEL ERIQNLLGTK QSEADALAVL KKAFRDQKEE
LLKSIEDIEE RTDRERLKDL TRQALQQRLR VFNQLEDELN SHEHELCWLK DKAKQIAQKD
VAFAPEVDKE INRLEVTWDD TKKLIHENQG QCCGLIDLMR EYQNLKSAVT KVLENATNVI
ATKTTVKDQE DLKWALSKHE AAKNEMCNKQ KDLDNFTSKG KQLLSELKKI HSGDFIVVKT
DLESTVDKWL DISERIEENM DRLRVSLSVW DDVLTSKDEI DGWSNHSVPQ MTESISNLND
SLRAEEFLKE FESEVKKKTL RLEELRSKVN DLKELTKNPE TPPDLQFIEA DLRQKLEHAK
EITEEAKGTL KEFTTQSAQV EKFINDTATW LTKLEESLMN CAQTETCEAL KKVKDIQKEL
QSQQSNISTT QENLNSLCRK YHSVELGSLG SAMTGLIKRH EAVSQSCSKT QASLQDSLEK
HFNESMQEFQ EWFSGIKAAA KESSDRTGDS KVLEAKLHDL QNILDSVSDG QSKLDVVTRE
GQTLYAHLSK QIVSSIQEQV TKANEEFQAF LKQCLKDKQA LQDCALELGS FEDQHRKLNL
WIHEMEERLS TENLGESKQH IPEKKNEVHK IEMFLGELLA ARESLDKLSQ RGQLLSEEGH
GAGKESRLCS QLLTSYQNLL RMTKEKLRSC QVALQEHEAL EEALQSMWSW VKDMQDRLAS
AESTVGSKDA LERRLLQVQE ILLMKGEGEV KLNMAIGKGE QALRSSNKEG QKVIQTQLQT
LKDVWANIMG SSVHAQSTLE SVISQWNDYL EWKNQLEQWM ESVDQKVEHP LQLQPGLKEK
FSLLDHFQSI VSEAEDHAGA LQRLTTKARE LYQKTEDEAF TDTAQEELKT QFNDILTVSK
EKMRKVEEIV KDHLVYLDAV QEFTDWLHSA KEELHRWSDM SGDSPATQKK LSKIKELMDS
REIGASRLSR VESLAPAVKQ NTTASGCELL HTEMQALRAD WKQWEDSVFQ TQTSLENLVS
QMALSEQEFS GQVAQLEQAL EQFSALLTSW TQQLALLEGK NTDKELVECW QKGREILDAL
QKAEPQTENL KSQLNELCRF SGDLSTYSGK VSGLIKEYNC LCLQASKGCQ NKEQILQQRF
LRAFKDFQQW LVNAKITTAK CFDIPQNINE VSTSLQKIQE FFSESENGQH KLNMMLSKGE
LLCTLLTKEK ASGIQAKIAT AKEDWKNFHS NLHQKESALE NLKIQMKDFE VSAEPVQDWL
SKTEKMVHES SNRLYDLPAK RREQQKLQSV LEEINCYEPQ LRRLKEKAQQ LWEGQAASRS
FMHRVSQLSS QYLALSNVTK EKVSRLDRIV AEHNQFSLGI KDLQDWMTDT VHMLDSYCHP
TSDKSVLDSR MLKLEALLSV KQEKEIQMKM IVTRGESVLQ NTSPEGIPAI QQQLASVKDM
WASLLSAAIR CKSQLEGALS KWTSYQDDVR QFSSWMDGVE ASLNESERQH AELREKTAAL
GKAKLLNEEV LSHGSLLETI EVKGAGMTEH YVTQLEFQDL QERYGAIRER TKEAVTKSEK
LVRLHQEYQR DLKAFEAWLE KEQEKLDRYS VLEGDAHTHE TALRDLQELQ VCCAEGQALL
NSALHTREEV IPSGIPQTED RALESLRQDW QAYQQRLSET RTQFNNVVNK LRLVEQKFQQ
VDEWLKTMEE KVNPRTGRQS SRAAKEMELH QMKKWHEEIT AYRDEVEEVG ARAQEILDES
HVSSRMGCQA TQLTSRYQAL LLQVLEQIKF LEEEIQSLEE SELSLSSYSD WYSSTHKNFK
NVAAKIDKVD KAMMGKKMKM LESLLKDMEK GQSLLKSTRE KGERALKYLE DGEAETLRKE
IHDHMEQLKE LTGTVRKEHM TLEKGLHLTK EFSDKYKALT QWIAEYRDIL HGPEEPKMEL
YEKKAQLSKY KSLQQTVLSH EPSVKSVREK GEALLELVQD VTLKDKIDQL QSDYQDLCSA
AKEHVCSLEA KVKDHEDYNS ELQEVEKWLL QMSGRLVAPD LMETSSLETI TQQLARHKAM
MEEIAGFEDR LNDLKTKGDN LISQCADHLQ AKLKQNVHAH LQGTKDSYSA ICSTAQRVYQ
SLEHELQKHV SRQDTLQQCQ AWLSAVQPDL KPSANPPLSR AEAVKQVKHF RALQEQARTY
LDLLCSMCDL SNSSVKTTAK DIQQTEQMIE QRLAQAQNLT QGWEEIKHMK AELWGYLQDA
DQQLQNMKRR HSELELNIAQ NMVSQVKDFV KKLQCKQASV TTITEKVDEL TKKQESPEHK
EISHLNDQWL DLCLQSNNLC LQREEDLQRT RDYHDRMNVV EGFLEKFTTE WDNLARSDAE
STAVHLEALK KLALALQERK KAIEDLKEQK QKMIEHLNLD DKELVKEQTS HLEQRWFQLE
DLVKRKIQVS ITNLEELSVV RSRFQELMEW AEEQQPNITE ALKQSPPPDM AQNLLMDHLA
ICSELEAKQV LLKSLTKDAD RVMADLGLNE RQIIQKALSD AQRHVSSLSD LVGQRRKYLN
KALSEKTQFL MAVFQATSQI QQHERKIMFR EHICLLPDDV SKQVKTCKSA QASLKTYQNE
VTGLWAQGRE LMKGVTEQEK SEVLGKLQEL QSVYDTVLQK CSHRLQELEK NLVSRKHFKE
DFDKACHWLK QADIVTFPEI NLMNETAELH TQLAKYQHIL EQSPEYENLL LSLQRTGQAI
LPTLNEVDHS YLDEKLHALP LQFNVIIDLA KDKFYKVQEA MLARKEYASL IELTSQSLHD
LEDQFSRMSQ IPGHLSVEEA LSLQDSWRAL GGEVAGLAEA MDELNQKKES FRSTGQPWQP
DKMPQLVTLY HRLKRQTEQR VSFLEDTTSA YQEHERMCLQ LEKQLEAVRM EQSKVNEETL
PAEEKLKVYH SLAGSLQNSG ILLKRVTRHL EDLVSHLDPA AYEKAKHQLQ AWQEELKLLT
SAIGATVTEC ESRMVQSRDF QTELSRSLDW LRSVEAALSG PLCLDPNLRD IQEEIRKVQI
HQEEVQSSLR IMNALSNKEQ EKFMRAKELI SADLQRTLAE LSELDGALQE ALHTRQTTLT
QIYSQCQRYY QVFQAANDWL EDAHEMLQLT GNGLDVESAE ESLKSHMEFF SAEDQFHSNL
EELQGLVANL DPLIKPTGKE DLAQKMASLE EKSQMIIQDS HAQLELLQRC AAQWQDYQKA
REEVIELMNE AEKKLSEFSL LKTSSSHEAE EKLSEHKALV SVINSFHEKI VALEGEASEL
ERTGNDASKA AISRSTTAVW QRWTRLRAVA QDQEKLLEDA VDEWTSFNNR VKKASEMIDQ
LQDKLPGSSA EKASKAELVT LLEYHDTFTL ELERQQSALG MLRQQALSML QDGVTPSPGG
EPPTVQEITA MQDRCLNMQE KVKKNGKIVK QELKEREVVE TQISSVKSWV QETKEYLGNP
TIEIDAQLEE LKILLTEAIN HRQNVEKMAE EQKNKYLGLY TILPSELSLQ LAEVALDLGT
IHDQIQDKVK EVEQSKTMSQ EFSQQIQKIA RDLTTILTKL RAKTDNLVQA KTDQKVLGEE
LDGCHLKLME LDKAVQKFSE QNGQLGKPLA KKIGKLTELH QQTIRQAENQ LSKLNQATSH
LEEYNEMLEL ILRWIEKTKI LVHGKIAWNS ASQLREQYIS HQTMLEESED IHNDLEAMTE
KLQYLDSVYH TEIMSQQVAD LGRETEELRQ VIKIRLQSLH DAAKDMKKFE AELRNLQVAL
EQAQTTLTSP EVGRLSLKEQ LSHRQHLLSE MESLKPKVHA VQVCQSALRI PEDVVTSLPL
CHAALHLQEE ASRLQHTAIQ QCNIMQAHNR LCFCFFPSKE AVVQYEQYEQ EMQHLQELIE
GAHREIEDKP VATSNIQELQ AQISRHEELA QKIKGYQEQI ASLNSKCKML TVKAKHATML
LTVTEVEGLA EGTEDLAGEL LPATSAHPSV VMMTAGRCHT LLSPVTEESG EEGTNSEISS
PPACRSPSPV ANTDASVNQD IAYYQALSPE RLQTDAAKVP PSTLPPQELY EPGLEPSATA
KLDDLQRSWE TLKNVISEKQ RTLYEALERQ QKYQDSLQSI STKMEAIEMK LSESLEQGRS
PESQMAEHQA LMDEILMLQE EISELQSALA DELVSESPES EPAEQLALQS TLTVLAERMS
TIKMKASGKR QLLEEKLNDQ LEEQRQEQAL HRYRCEADQL DHWLLSTKAT LDIALGSPKE
PMDMEAQLVD CQNMLVEIEQ KVVALSELSV HNENLLLEGK AHTKDEAEQL AVKLRTLKGS
LLELQRALQD RQLHIQGTAQ EKEESDADLA ATQSPGVQEW LSQARSTWTH QRQSSLQQQK
ELEQELAEQK SLLQSVASLG EEILTQHSAP ETSGGVGEKP DVLSQELGME GEKSPAEDQM
RMKWESLHQE FSTKQKLLQN VLEQEQEQVL YSRPNRLLSG VPLYKGDGQA QDKSAVTSLL
DGLNQVFEEV SSQGGGTKKQ SVDLERKLYD GVSATSTWLD DVEERLFVAT ALLAEEPETC
IFNQETLAKD IKEMSEEMDK NKNLFSQAFP ENGDNRDVIE DTLGCLLGRL SLLDSVVNQR
CHQMKERLQQ ILNFQNDLKV LVTSLADHKY IILQKLAKMF EQPVAEQIEA IQQAEDGLKE
LDAGIIELKR RADKLQIEQP SMQELSKLQD MYDELLMTIG SRRSGLNQNL ALKSQYERAL
QDLADLLETG REKTAGDQKI IVSSKEEIQQ LLDKHKEYFQ GLESHMILTE TLFRKIISFA
VPRETQFHTD LMAQASAVLK GAHKRGVELE YILETWSQLE KEHWELSRQL EVVESSTPSV
GLVEESEDRL IDRIALYQHL KSSLNEYQPK LYQVIDDGKR LLISVSCPDL ESQLNQLGEH
WLNDTNKVSK ELHRLETILK HWTRYQSESA DLIHWLQSAK DRLEFWTQQS VTVPQELEMV
RDHLNGFLEF SKEVDAKSTL KSSVLSTGNQ LLRLKKVDTA ALRSELSHID GQWNDLLTNI
PAVQEKLHQL QMDKLPSRHA ISEVMTWISL MESVIQKDEE NIKNSIGYKT IHEYLQKYKG
FQIDINCKQL TVDFVNQSVL QISSQDVESK RSDKTDFAER LGAMNKSWQI LQGLVTEKIQ
LLEGLLESWS EYENNVQCLK TWFETQEERL KQQHRIGDQA SVQNAMKDCQ DLEDLIKAKE
KEVEKIEQNG LALVQNKKEE VSGTVRSTLQ ELNQTWANLD HMVGQLKILL KSVLDQWSHH
KVAFDEINSC LMEARYSLSR FCLLTGSLEA VQVQVDSLQN LQDDLEKQEK SLQKFGSVTN
QLLKECHPPV TETLTNTLKE VNMRWNNLLE EIAEQLRASK ALLQLWQRYK DYFKQCAATV
QQQEGRTNEF LKAATDKDIG DDEVATWIQD CNDLLKGLGP IQDSLVVLHE LGGQLKQQVD
ASAASAIQSD WLSLKQQSHA LEQALCKQQT VLQAGVLDYE TFTKSLEALE TWIVEAEEIL
QGQDPSHSSD LSTIQERMEE LKGQMLKFSS MVPDLDRLNE LGYRLPLNDK EIKRVQNLNR
HWALISSQTT ERFSKLQSFL LQHQTFLEKC ETWMEFLVQT EQKLAVEISG NYQHLLEQQR
AHELFQAEMF SRQQILHSII FDGQHLLEQG QVDDRDEFNL KLTLLSNQWQ GVIRRAQQRR
GIIDSQIHQW QRYREMAEKL RKWLVEVSCL PVSGLGSVRI PLQQARALFD QVQFKEKVFL
RQQGSYILTV EAGKQLLLSA DSGAEATLQA ELAEIQEKWK SASVCLEEQK KKLAGLLQDW
EKCETGIADS LEKLRTFKKR LSQPLPDHHE ELHAEQMCCK ELENAVGSWT DDLAQLTVLK
KALCAYISAD DISILNERME LLQRQWEELC HQLSLRRQQV SERLNEWAVF SEKNKELCEW
LTQMESKVSQ NGDILIEEMI EKLRKDYQEE IAVAQENKIQ LQQMGERLAR ASHESKASEI
EYKLGKINDR WQHLLDLMAA RVKKLKETLV AVQQLDKNMS SLRTWLAHIE SELAKPIVYD
SCDSEEIQKK LNEQQELQRD IEKHSTGVAS VLNLCEVLLH DCDACATDAE CDSIQQATRN
LDRRWRNICA MSMERRLKIE ETWRLWQKFL DDFSHFEDWL KISERTAAFP SSSGVLYTVA
KEELKKFEAF QRQVHESLTQ LELINKQYRR LARENRTDAA GSLKQMVHKG NQRWDNLQKR
VTSILRRLKH FIGQREEFET ARDSILVWLT EMDLQLTNIE HFSECDVQAK IKQLKAFQQE
ISLNHNKIEQ IIAQGEQLIE KSEPLDAAVI EEELDELRRY CQEVFGRVDR YHKKLMRLPL
PDDEHDLSDR ELELDEAGAL SDLHWRDTTD GVLSPQPSSN PSLSLAQPLR SERSGRDTPA
SVDSIPLEWD HDYDLSRDLE SAVSRTLPSE DEEGPEDKDF YLRGAVGLSG DPGALESQIR
QLGKALDDSH FQMQLTENII RSKTPTGPEL DSGYRGYMKL LGECSGSIDS VKRLEHKLTE
EEDHFPGFVN LNSTETQTAG VIDRWELIQA EALSKELRMK QKPQRRQQLD SDLNSVLTWL
RETEGDLEQL QRLQLSTDIQ SIALQIQKLK ELQKAVDQRK AIILSIHLCS SEFTQTGQEE
SQDLQDRLSQ MNGRWDRVCS LLEEWRGLLQ DALMQCQDFH EMSHSLLLML ENIDRRKNEI
VPIDSNLDAE ILQDHHKQLK QIRHELLESQ LKVASLQDMS CQLLVNAEGT DCLEAKEKVH
VIGNRLKLLL KEVSRHIKEL EKLLDMSSSQ QDLSSWSSAD ELDTSGSVSP TSGRSTPNRQ
KTPRGKCSLS QPGPSVNSPH SRSIKGGSDS SLSEPRPARS GRAFLFRVLR AALPLQLLLL
LLIGLACLVP MSEEDYSCAL SNNFARSFHP MLRYTNGPPP L
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