ID A0A452EWE5_CAPHI Unreviewed; 1009 AA.
AC A0A452EWE5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN Name=LOC102188844 {ECO:0000313|Ensembl:ENSCHIP00000016298.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000016298.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000016298.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000016298.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR EMBL; LWLT01000006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452EWE5; -.
DR Ensembl; ENSCHIT00000024105.1; ENSCHIP00000016298.1; ENSCHIG00000016572.1.
DR GeneTree; ENSGT01030000234638; -.
DR OMA; XKERATW; -.
DR Proteomes; UP000291000; Chromosome 6.
DR Bgee; ENSCHIG00000016572; Expressed in thymus and 2 other cell types or tissues.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR Gene3D; 2.60.40.1360; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF28; EPIDIDYMIS-SPECIFIC ALPHA-MANNOSIDASE; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Signal {ECO:0000256|RuleBase:RU361199};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT CHAIN 24..1009
FT /note="Alpha-mannosidase"
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT /id="PRO_5018823009"
FT DOMAIN 355..438
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
FT REGION 971..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1009 AA; 115136 MW; 9755790268CF1032 CRC64;
MEPRGWLPLL LQLGLMWPLG ALSEPRLRVF VVPHSHMDVG WLHTVQESMQ VYVTNVYNSV
VEELTLEKKR RFIAVEQEYF RLWWDGVASD GQKSQVRQLV AEGRLEFVLG GQVMHDEAVT
HFDDQILQLT EGHGFLYETF GVRPQFSWQV DPFGASSTTP TLFALAGFNA HVISRIDYNL
KKAMQDNREL QFVWRGSRSL SAQQEIFTHV LDQFSYWPPN APLSLSEGFN WDGEAIFPGT
SPDDMYLQMQ IPVTKDNIQI FTSLLVKNAL ARATWFRTPH VLWPWGCDRQ FFNASLQFTN
MDIVMEYINS HSLEFNLSVE YATLGDYFRA VHSDQVSWQV RDHRDFLPYS SDMYHAWTGF
YASRSGLKGL ARRASSLLYA GESMFTRYVL LAPHRFLDPA WGLQQLQQLR WVVSEVQHHD
AITGTHVPNV GDMFVEHLST GMQGVHNLMS YIIQDRFPAH SACSLCAGPE PGGHFAVVYN
PLAWTVTTII TLTVDFPKVS VTDESGLPVP AQVQPSKEMP SAYDLHVLTM IPGLSYRHYS
IRPSRSSQEK TGEPEPFVAK TMQFGGRLRR LARQVGGSLV PVNNDCYIVF LDLDTNLMHS
VWERQSNRKV YMTQQFMEYH TNSDVWKGPV SDNYVFTPSG VAEPAWEAVR MEIVEGPLVT
EIRQYFYRKV NDSEPTFAIY SRLARGPQGS GGELLCHRIE QEYRVGPLEL NREAILRTST
KLNTGQVLHS DNNGYQMQRR PYRDYKNNTI ARNYYPMVQS AFIQSRRSRL VLLSEQAHGV
SSQGNGQVEV MLHRRLVNND PGNLVVDLTL NDPSVVHPVL WLLLGSRALT SGLRQRSRLA
LQHRPVVMLR EINGEIAPRG SGSRQQEAVT LPPSIHLQIL SIPGWKYSSN HTEHLRTLQK
GEAGVQADLR RVLLRLQHLY EVDQDPVLSR PVTVNLRSVL GGLGSVVSVE ERSLTGTWDV
NEMRRWTWSR RDPHHHRGNS SQPSPPPGGP EVTIYPKEIR TFFIHFQEH
//
