ID   A0A452EXW9_CAPHI        Unreviewed;       950 AA.
AC   A0A452EXW9;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Rubicon autophagy regulator {ECO:0000313|Ensembl:ENSCHIP00000016869.1};
GN   Name=RUBCN {ECO:0000313|Ensembl:ENSCHIP00000016869.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000016869.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Ensembl:ENSCHIP00000016869.1, ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000016869.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   EMBL; LWLT01000001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A452EXW9; -.
DR   Ensembl; ENSCHIT00000024678.1; ENSCHIP00000016869.1; ENSCHIG00000016903.1.
DR   GeneTree; ENSGT00940000160658; -.
DR   OMA; KDVIFPW; -.
DR   Proteomes; UP000291000; Chromosome 1.
DR   Bgee; ENSCHIG00000016903; Expressed in ileum and 17 other cell types or tissues.
DR   GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   CDD; cd17686; RUN_RUBCN; 1.
DR   Gene3D; 1.20.58.900; -; 1.
DR   InterPro; IPR025258; RH_dom.
DR   InterPro; IPR048569; RUBC_PIKBD.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   PANTHER; PTHR45971; PHOX (PX) DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45971:SF3; RUN DOMAIN BECLIN-1-INTERACTING AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF13901; RH_dom; 1.
DR   Pfam; PF21054; RUBC_PIKBD; 1.
DR   Pfam; PF02759; RUN; 1.
DR   SMART; SM01175; DUF4206; 1.
DR   SMART; SM00593; RUN; 1.
DR   SUPFAM; SSF140741; RUN domain-like; 1.
DR   PROSITE; PS50826; RUN; 1.
PE   4: Predicted;
KW   Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT   DOMAIN          48..189
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
FT   REGION          244..424
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          547..567
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        284..317
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        332..402
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        547..565
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   950 AA;  106327 MW;  DEB49F678B47AB55 CRC64;
     EISFRTGLEI EQGNGQQVRE KVREHWQLLG NLKTTVEGLV SANSPNVWSK YGGLERLCRD
     MQSILYHGLI HDQVCCRQTD YWQFVKDIRW LSPHSALHVE KFINLHENGQ SGTDGVSERA
     VAELWLQHSL QCHCLSAQLR PLLGDRQYIR KFYTDTAFLL SDAHVTAMLQ CLEAVEQNNP
     RLLAQIDASM FARKHESPLL VTKSHSLTAL PGSASTPSTN SAQHSYFGSF SSLHQIPHHN
     LERRSTSFSL SGPPRKPQES RGHVSAAEDQ TVLDPLLPVT ALAKDSPSTP NEMSSSTLTS
     PLEASWVSSQ NDSPSDASEG PEYLAIGNQD PRGRTASCQS HSSNTESSSS NLFSSSSSQK
     PDSAASSLGD QEGGRQSQLS SVLRRSSFSE GQTLTVTGGT KKSHTRSHSD TNIASRGAPG
     GPRNITIIVE DPIAEGSQYL CSGEGMFRRP SEGQSLISYL SEQDFGSCAD LEKENAHFSI
     SESLIAAIEL MKCNMLSQCL EEEEGEEDSD REIQELKQKI RLRRQQIRTK NLLPGYQEME
     HGSFRLTSSS SQFSSRDSAQ FSDSGSADDE VDEFEIQGLL SSCRSASLDS LHFSSHCFLH
     STSAEAVAMG LLKQFEGMQL PAASELEWLV PEHDAPQKLL PIPDSLPISP DDGQHADIYK
     LRIRVRGNLE WAPPRPQIIF NVHPAPTRKI AVAKQNYRCA GCGIRTDPDY IKRLRYCEYL
     GKYFCQCCHE NAQMVIPSRV LRKWDFSKYY VSNFSKDLLI KIWNDPLFNV QDINSALYRK
     VKLLNHVRLL RIQLCHMKNM FKTCRLAKEL LDAFDTVPGH LTEDLHLYSL NDLTATRKGE
     LGPRLAELTR AGAAHVERCV LCQAKGFICE FCQNEDDIIF PFELHKCRIC EECKACYHKT
     CFKSGSCPRC ERLQARRELL AKQSLESYMS DYEEEPTEAL ALEATDLETT
//