ID A0A452EYW8_CAPHI Unreviewed; 1175 AA.
AC A0A452EYW8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Adenosine deaminase RNA specific {ECO:0000313|Ensembl:ENSCHIP00000017234.1};
GN Name=ADAR {ECO:0000313|Ensembl:ENSCHIP00000017234.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000017234.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000017234.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000017234.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017901684.1; XM_018046195.1.
DR AlphaFoldDB; A0A452EYW8; -.
DR SMR; A0A452EYW8; -.
DR STRING; 9925.ENSCHIP00000017234; -.
DR Ensembl; ENSCHIT00000025043.1; ENSCHIP00000017234.1; ENSCHIG00000017156.1.
DR GeneID; 102172585; -.
DR KEGG; chx:102172585; -.
DR CTD; 103; -.
DR GeneTree; ENSGT00940000157243; -.
DR OMA; ERMQMKR; -.
DR OrthoDB; 118472at2759; -.
DR Proteomes; UP000291000; Chromosome 3.
DR Bgee; ENSCHIG00000017156; Expressed in prefrontal cortex and 17 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0044530; C:supraspliceosomal complex; IEA:Ensembl.
DR GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006382; P:adenosine to inosine editing; IEA:Ensembl.
DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR GO; GO:0060216; P:definitive hemopoiesis; IEA:Ensembl.
DR GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; IEA:Ensembl.
DR GO; GO:0097284; P:hepatocyte apoptotic process; IEA:Ensembl.
DR GO; GO:1903944; P:negative regulation of hepatocyte apoptotic process; IEA:Ensembl.
DR GO; GO:1900369; P:negative regulation of post-transcriptional gene silencing by regulatory ncRNA; IEA:Ensembl.
DR GO; GO:0060339; P:negative regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0045070; P:positive regulation of viral genome replication; IEA:Ensembl.
DR GO; GO:0031054; P:pre-miRNA processing; IEA:Ensembl.
DR GO; GO:0035455; P:response to interferon-alpha; IEA:Ensembl.
DR GO; GO:0070922; P:RISC complex assembly; IEA:Ensembl.
DR GO; GO:0002566; P:somatic diversification of immune receptors via somatic mutation; IEA:Ensembl.
DR CDD; cd19913; DSRM_DRADA_rpt1; 1.
DR CDD; cd19915; DSRM_DRADA_rpt3; 1.
DR Gene3D; 3.30.160.20; -; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR002466; A_deamin.
DR InterPro; IPR044456; ADAR1_DSRM_1.
DR InterPro; IPR044457; ADAR1_DSRM_3.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR042371; Z_dom.
DR PANTHER; PTHR10910:SF107; DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE; 1.
DR PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR Pfam; PF02137; A_deamin; 1.
DR Pfam; PF00035; dsrm; 3.
DR Pfam; PF02295; z-alpha; 2.
DR SMART; SM00552; ADEAMc; 1.
DR SMART; SM00358; DSRM; 3.
DR SMART; SM00550; Zalpha; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 3.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR PROSITE; PS50137; DS_RBD; 3.
DR PROSITE; PS50139; Z_BINDING; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}.
FT DOMAIN 130..196
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 241..305
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 452..520
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 563..631
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 675..743
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 835..1170
FT /note="A to I editase"
FT /evidence="ECO:0000259|PROSITE:PS50141"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..546
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1175 AA; 130293 MW; 936C73F99FC172F6 CRC64;
MDPRQGYSLN RYQARPAQGY EHSRHRHQQP ERGPYRDSFQ LQQIEFLKGQ LPEVPLFGKQ
PPSLPPLLPG LWPRFPGPPA RGGPLQIQGV PRGVPLRSQV VPRRFQRPFP RGHIRPWRGV
DRLSSHFQGL TISQDQEQRT LKLLDELGDG KATTARDLAR KLQAPKKDIN RVLYSLAEKG
KLHQEVGSPP LWRATVPVQA RNQPSQVTRA ESQTPGAPSP DSSVETEDRS TPCGLEEPPE
PLDMAEIKEK ICDHLFNVSS SSALNLAKNI GFTKARDVNA VLIDLERQGD VYRQGTTPPI
WYLTDKKRER IQIKRNKDSV PETTQAAAIL EAGKTTEGPT CNSPASDASN STVTPGKVEN
GQEPVVKLKL KQEATAEAVK LKPPVHDNGP SKTGYVDFEN GQWATDDIPD DLNSIHAAPG
EFRAIMEMPS FYSHGLPRCS PYKKLTECQL KNPISGLLEY AQFASQTCEF NMIEQSGPPH
EPRFKFQVVI SGREFPPAEA GSKKVAKQDA ATKAMTILLE EAKAQDSGSP EEACRYSSER
EPEKTAESQT ATPSATSFLS GKNPVTTLLE CVHKLGSSCE FRLLSREGPA HDPKFQYCVA
MGTHTFPTAS APSKKAAKQM AAEEAMKALQ GEATSSASSD DQPGSTNTEA FDTLESVMPN
KVRRISELVR YLNTNPVGGL LEYARSHGFA AEFKLVDQSG PPHEPKFVYQ AKVGGRWFPA
VCAHSKKQGK QEAADAALRV LIGEDEKAER MGFTEVTPVT GASLRRTMLL LSRSPEAKRK
TLPLTGSTFH DQIAMLSHRC FNALTNSFQP SLLGRKILAA IIMKKDSDDL GVVVSLGTGN
RCVKGDSLSL KGETVNDCHA EIISRRGFIR FLYSELMKYN PQTAKDSIFE PAKGGEKLQI
KKSVSFHLYI STAPCGDGAL FDKSCSDRAV ESTDSRHYPV FENPKQGKLR TKVENGEGTI
PVESSDIVPT WDGIRLGERL RTMSCSDKIL RWNVLGLQGA LLTHFLQPVY LKSVTLGYLF
SQGHLTRAIC CRVTRDGSAF EDGLRHPFIV NHPKVGRVSV YDSKRQSGKT KETSVNWCLA
DGYDLEILDG TRGTVDGPRN ELSRVSKKNI FLLFKKLCSF RYRRDLLRLS YGEAKKAARD
YEIAKNYFKK SLKDMGYGNW ISKPQEEKNF YLCPV
//
