ID A0A452EZN8_CAPHI Unreviewed; 871 AA.
AC A0A452EZN8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000017556.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000017556.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000017556.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452EZN8; -.
DR STRING; 9925.ENSCHIP00000017556; -.
DR Ensembl; ENSCHIT00000025367.1; ENSCHIP00000017556.1; ENSCHIG00000017345.1.
DR GeneTree; ENSGT00940000163312; -.
DR OMA; WLNENAL; -.
DR Proteomes; UP000291000; Chromosome 7.
DR Bgee; ENSCHIG00000017345; Expressed in frontal cortex and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF133; PROTOCADHERIN ALPHA-9; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..871
FT /note="Cadherin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019126784"
FT TRANSMEM 698..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..133
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 157..242
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 243..350
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 351..455
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 456..565
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 573..678
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 871 AA; 94648 MW; 9C4238362FD3E81B CRC64;
MVYSQRKSPG SQRLLLSILL LVAWESGSGQ VRYSVLEEAK HGTFVGRIAQ DLRLELQELV
PRLFRVASKD LGDLLEVNLQ NGILFVNSRI DREELCGRSA ECSIHLEVIL DQPLQVFHVE
VEVKDINDNP PVFQGTQKNL FIAESRPLDF RFPLEGASDA DIGENAQLTY RLSSSEYFSL
EVPATDQQVK PLSLVLRKPL DREESPELHL VLTATDRGKP ELTGTVQLHI NVLDANDNAP
VFDRTLYAVK LAENVPNGTL VIKLNASDLD EGLNADIIYS FSSDASPDIN FKFYIDPVSG
EITVAGHIDF EERKTYKIRV EATDRGYPPL AGHCTVLVEV LDTNDNPPVL TVTSLSLPIS
ENAQPGTVIT LINVSDRDSG ANGQVTCSLT PHVPFKLVST FKNYYSLVLD SALDRESVAN
YELVVTARDG GSPSLSATAS VSVEVADVND NAPAFPQPEY TVFVKENNPP GCHIFTVSAR
DADAQENALV SYSLVERRVG ERALSSYVSV HAESGKVYAL QPLDHEELEL LQFQVSARDA
GVPPLGSNVT LQVFVLDEND NAPALLPPGS GGGPSALSQV VARSVGAGHV VAKVRAVDAD
SGYNAWLSYE LQPAAGGTSS PFRVGLYSGE ISTTRALDEA DTPRQRLLVL VKDHGEPALT
ATATVLLSLE DSGQAPKASS RALSGAAGSE TALVDVNVYL IIAICAVSSL LVLTLLLYMA
LRCSAPPSEG ACGPVKPRLV CSSEVESWSY LQERRQRVCS GEGPPKTDLM AFSPSLPPFP
GAEAIGKQQD LNVDHCTENS VLSLPETIVC QSLIGGMRLC KLLSQTKKKP QKRKYTKNSP
YKILSIQYQI DHFTISRYIL YYQISFIMSI I
//
