ID A0A452F191_CAPHI Unreviewed; 281 AA.
AC A0A452F191;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=AlkB homolog 3, alpha-ketoglutarate dependent dioxygenase {ECO:0000313|Ensembl:ENSCHIP00000017955.1};
GN Name=ALKBH3 {ECO:0000313|Ensembl:ENSCHIP00000017955.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000017955.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000017955.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000017955.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
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DR EMBL; LWLT01000015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452F191; -.
DR Ensembl; ENSCHIT00000025769.1; ENSCHIP00000017955.1; ENSCHIG00000017579.1.
DR GeneTree; ENSGT00940000157226; -.
DR OMA; FEFHQPT; -.
DR Proteomes; UP000291000; Chromosome 15.
DR Bgee; ENSCHIG00000017579; Expressed in ovary and 16 other cell types or tissues.
DR GO; GO:0051213; F:dioxygenase activity; IEA:InterPro.
DR GO; GO:0006307; P:DNA dealkylation involved in DNA repair; IEA:InterPro.
DR GO; GO:0035552; P:oxidative single-stranded DNA demethylation; IEA:InterPro.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR InterPro; IPR027450; AlkB-like.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR032854; ALKBH3.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR PANTHER; PTHR31212; ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3; 1.
DR PANTHER; PTHR31212:SF4; ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3; 1.
DR Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 167..273
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 281 AA; 32563 MW; 001BA43A8742D1A2 CRC64;
MEDKRRRARV QGAWAGPAKS QATAQPAPTA ENNLQQRPGK TWMNKEQHLS DRQFVFKEPQ
EVNSCFFFNK GVYEISMSPT GISRVCLCPG FVDLKEANSV FEQLCRDVPW KQRTGIRDDV
TYQQPRLTAW YGELPYTYSR ITMEPNPHWH PVLLTLKSHI EENTGHTFNS LLCNLYRNEK
DSVDWHSDDE PSLGRCPIIA SLSFGATRMF EMRKKPPPED NGDYTYVDRV KIPLDHGTLL
IMEGATQADW QHRVPKEYHS RGPRINLTFR TVYPDPRGVH W
//
