ID   A0A452F1Y3_CAPHI        Unreviewed;       937 AA.
AC   A0A452F1Y3;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Sorting nexin 14 {ECO:0000313|Ensembl:ENSCHIP00000018337.1};
GN   Name=SNX14 {ECO:0000313|Ensembl:ENSCHIP00000018337.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000018337.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Ensembl:ENSCHIP00000018337.1, ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000018337.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   EMBL; LWLT01000012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_017908666.1; XM_018053177.1.
DR   AlphaFoldDB; A0A452F1Y3; -.
DR   Ensembl; ENSCHIT00000026153.1; ENSCHIP00000018337.1; ENSCHIG00000017765.1.
DR   GeneID; 102183328; -.
DR   CTD; 57231; -.
DR   GeneTree; ENSGT00950000182856; -.
DR   OrthoDB; 2877434at2759; -.
DR   Proteomes; UP000291000; Chromosome 9.
DR   Bgee; ENSCHIG00000017765; Expressed in frontal cortex and 18 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR   CDD; cd06877; PX_SNX14; 1.
DR   CDD; cd08722; RGS_SNX14; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037436; SNX14_PX.
DR   InterPro; IPR037892; SNX14_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        28..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        52..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          130..304
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          336..468
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          561..681
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
SQ   SEQUENCE   937 AA;  109197 MW;  0D60673A4C8C993E CRC64;
     MAPWVRTMGE KLKQRLRLDV GREICRQYPL FCFLLLCLSA ASLLLNRYLH VLMIFWSFVA
     GVVTFYCSLG PDSLLPNIFF MIKYKPKQLG LQELFPQGRS CAVCGKVKCK RHRPSLLLEN
     YQPWLDLKIS SKVDASLSEV LELVLENFVY PWYRDVTDDE SFVDELRIIL RFFASVLIRR
     IHKVDIPSII TKKLLKAAMK HIEVIVKASQ KVENTEFLQQ AALEEYGPEL HVALRSRRDE
     LHYLRKLTEL LFPYILPPKA TDCRSLTLLL REILSGSVFL PSLDFLADPD TVNHLLIIFI
     DDSPPEKATE PPSPLVPFLQ KFAEPRNKKP SVLKLELKQI REQQDLLFRF MNFLKQEGAV
     HVLQICLTVE EFNDRILRPE LSNDEMLSLH EELQKIYKTY CLDESVDKIR FDPFIVEEIQ
     KIAEGPYIDV VKLQTMRCLF EAYEHVLSLL ENVFTPMFCH SDEYFRQLLR GAESPTRNSK
     FNRSTQKRGE SFGISRIGSK IKGVFKSTTM EGAMLPNYGL AEGEDDFIEE GIVVMEDDSP
     VEAVNTPNTP RNLAAWKISI PYVDFFEDTS SERREKKERI PVFCIDVERN DRRAVGHEPE
     HWSVYRRYLE FYVLESKLTE FHGTFPDAQL PSKRIIGPKN YEFLKSKREE FQEYLQKLLQ
     HPELSNSQLL ADFLSPNGGE TQFLDKILPD VNLGKIIKSV PGKLMKEKGQ HLEPFIMNFI
     NSCESPKPKP SKPELTILSP TSENNKKLFN DLYKNNANRA ENTERRQNQN YFMEMMTVEG
     VYDYLMYVGQ VVFQVPDWLH HLLMGTRILF KNTLEMYTDY YLHCKLEQLF QEHRLVSLIT
     LLRDAVFCEN TEPRSLQDKQ KRAKQTFEGM MNYIPDLIVK CIGEEAKYES IRLLFDGLQQ
     PVLNKQLTYV LLDIVIQELF PELNKVQKEV TSVTSWI
//