ID A0A452F2C3_CAPHI Unreviewed; 1822 AA.
AC A0A452F2C3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Zinc finger protein 646 {ECO:0000313|Ensembl:ENSCHIP00000018318.1};
GN Name=ZNF646 {ECO:0000313|Ensembl:ENSCHIP00000018318.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000018318.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000018318.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000018318.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005697779.2; XM_005697722.3.
DR RefSeq; XP_005697780.2; XM_005697723.3.
DR RefSeq; XP_005697781.2; XM_005697724.3.
DR RefSeq; XP_005697782.2; XM_005697725.3.
DR STRING; 9925.ENSCHIP00000018318; -.
DR Ensembl; ENSCHIT00000026133.1; ENSCHIP00000018318.1; ENSCHIG00000017805.1.
DR GeneID; 102177117; -.
DR KEGG; chx:102177117; -.
DR CTD; 9726; -.
DR GeneTree; ENSGT00940000161588; -.
DR OMA; RQEQPWE; -.
DR OrthoDB; 4605409at2759; -.
DR Proteomes; UP000291000; Chromosome 25.
DR Bgee; ENSCHIG00000017805; Expressed in thymus and 16 other cell types or tissues.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 16.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24376; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR24376:SF245; ZINC FINGER PROTEIN 717; 1.
DR Pfam; PF00096; zf-C2H2; 16.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00355; ZnF_C2H2; 32.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 15.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 27.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 31.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 8..36
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 47..69
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 74..101
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 238..261
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 265..292
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 293..320
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 373..401
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 400..427
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 464..486
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 491..513
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 574..596
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 614..636
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 641..668
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 818..840
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 845..872
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 878..906
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1051..1073
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1078..1105
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1196..1218
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1223..1250
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1251..1278
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1292..1314
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1319..1346
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1357..1384
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1525..1552
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1552..1579
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1579..1602
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1667..1690
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1694..1721
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1722..1749
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1751..1778
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 90..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 898..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 971..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1103..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1370..1525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1602..1653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1771..1822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..675
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1370..1387
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1488..1506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1794..1810
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1822 AA; 199415 MW; 09D2637053AFF869 CRC64;
MEDTPTSLSC SDCQRHFPSL PELSRHRELL HPSSSQGIEA DSIPRPYRCQ LCGRGYRHPG
SLVNHRRTHE TGLFPCTTCG KDFTNPMALK SHMRTHAPEG RRRRRPPRPK EATPCLQGET
VSTDSWAQRL GPGEGWENQK KHIEETSGCE SGPEPRATAG TWEGPPTRQR EGWEGQPDPE
EGVEGWGPTT NSARDTPLPT PASSLLSNLE QYLAESVVNF TGGQEPTQSP PAEEERRYKC
SQCGKTYKHA GSLTNHRQSH TLGVYPCAIC FKEFSNLMAL KNHSRLHAQY RPYQCPHCPR
AFRLPRELLE HQQSHEGESQ EQPWGEKGMP TTNGHTDESS QDQLPGTHIL NGSGELSTSG
ELEDIGLEEY RPFRCGDCGR TYRHAGSLIN HRKSHQTGVY PCSICSKQLF NAAALKNHVR
AHHRPRPGAG EDRQPSVLPA PLPLAESTRK ETEAPSSTLD HRPYKCNECG RAYRHRGSLV
NHRHSHRTGE YQCSLCPRKY PNLMALRNHV RVHCKAARRS TGPEPEGPPG LLKVELPPDP
AGPETTLLSD QGPGCKHEEG APAVPPATDR TMPQICSVCG MLFEDSRSLE HHRRTHGEGA
QSRTEARESP PRVFACRDCG KSYRHSGSLI NHRQTHQTGD FSCGACAKHF HTMAAMKNHL
RRHSRRRSRR HRRRAGSAGG GGEAKPPSDG NWAPEPVDSE GLGCPRDSSR ASLSGAEGSM
ESSGGCLQPA AERDNRGIER NEACFQGDKE SQGAEEGLER MEACFLDNVD IPGAEESNGT
RFCDGLPGVE EDQKPAPGQP SSPSRSASSA AWSAEVSHTC SDCGHSFPHA TGLLSHRPCH
PPGIYQCSLC PKEFDSLPAL RSHFQNHGPG EAVSTQPFLC CLCGMIFPGR AGYRLHRRQA
HDSGMTEGSE EEGEEEGAAG AISTHSPPLQ LSEAELLNQL QREVEALDGA GYGHICGCCG
QTYDDLGSLE RHHQSRNSGN TTDEVPSLLH HPAESGDATV VVADGVFEGT VTSLPAKCGD
AKPSEGVGAT LADSLCRQGE ESSLETQPRP FRCNQCGKTY RHGGSLVNHR KIHQTGDFVC
PVCSRCYPNL AAYRNHLRNH PRCKGSEPQV GPVPEAKGSG EAQTLAEEGL EQAEVERFQK
ELKVEPLEEG ARVKEEAWEE TTVKGEETTV KGEEMEPRLE TAEKGCQTEA SSERPFSCEV
CGRSYKHAGS LINHRQSHQT GHFGCQACSK GFSNLMSLKN HRRIHADPRR FRCAECGKAF
RLRKQLASHQ RVHLERSGGG ASRKLSLEDR PFRCGQCGRT YRHAGSLLNH RRSHETGQYS
CPTCPKTYSN RMALRDHQRL HSESRRRRAG LSRRAAVRCA LCGRGFPGRG SLERHLREHE
EETRGGQGGP DGTEGGQGNL ADDQGLEDRS GGTESGPQLE DGATRPAEPS QSPIRAAGLE
ATEPASWGMG EADEWRGDQG PVNHDGDWVP GGHVLTKPED ESGDSVPRSP SPLGNTQRNG
PSLTPVDSWD SGDCGPQPQP ESHSFSCSHC GKISCQSEGP LNHHSTHKTD RHYCLLCSKE
FLNPEATKSH SRNHIAAQTS CPDCGKAFES HHELASHLQT HARGLSQVSP QVEARSPKAG
AEEEEMELPG QGKAPSESPR APGENVGRAS GGQGAESLVA VHEERPFRCA QCGRSYRHAG
SLLNHQKAHT TGLYPCSLCP KLLPNLLSLK NHGRTHTDPK RHRCSICGKA FRTAARLEGH
GRVHAPREGP FSCPHCPRHF RRRISFLQHE QQHQEEWTVA SSGTPKAPAA GRGDLSLPPP
PTPTAPLLDP SPQWPTDLSF SL
//
