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Database: UniProt
Entry: A0A452F333_CAPHI
LinkDB: A0A452F333_CAPHI
Original site: A0A452F333_CAPHI 
ID   A0A452F333_CAPHI        Unreviewed;       887 AA.
AC   A0A452F333;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Cadherin-1 {ECO:0000256|ARBA:ARBA00023893};
DE   AltName: Full=Epithelial cadherin {ECO:0000256|ARBA:ARBA00032684};
GN   Name=CDH1 {ECO:0000313|Ensembl:ENSCHIP00000018796.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000018796.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Ensembl:ENSCHIP00000018796.1, ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000018796.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC       {ECO:0000256|RuleBase:RU004357}.
CC   -!- FUNCTION: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta
CC       precursors. Has a strong inhibitory effect on APP C99 and C83
CC       production. {ECO:0000256|ARBA:ARBA00025086}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC       ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}. Golgi
CC       apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   EMBL; LWLT01000020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A452F333; -.
DR   Ensembl; ENSCHIT00000026611.1; ENSCHIP00000018796.1; ENSCHIG00000018029.1.
DR   GeneTree; ENSGT00940000157175; -.
DR   OMA; LHEGHHD; -.
DR   Proteomes; UP000291000; Chromosome 18.
DR   Bgee; ENSCHIG00000018029; Expressed in descending colon and 15 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd00031; CA_like; 1.
DR   CDD; cd11304; Cadherin_repeat; 3.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR014868; Cadherin_pro_dom.
DR   InterPro; IPR000233; Cadherin_Y-type_LIR.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   PANTHER; PTHR24027:SF435; CADHERIN-1; 1.
DR   PANTHER; PTHR24027; CADHERIN-23; 1.
DR   Pfam; PF01049; CADH_Y-type_LIR; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08758; Cadherin_pro; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 4.
DR   SMART; SM01055; Cadherin_pro; 1.
DR   SUPFAM; SSF49313; Cadherin-like; 6.
DR   PROSITE; PS00232; CADHERIN_1; 2.
DR   PROSITE; PS50268; CADHERIN_2; 4.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003318};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003318};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        714..736
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          191..266
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          267..379
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          380..490
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          491..599
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   REGION          783..811
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   887 AA;  98224 MW;  009CD88C98D0E78C CRC64;
     GLPWALGAAT SLRSCCCCRY VSSWLCQEPE PCVPGFGAES YTFTVPRRNL ERGRVLGRVS
     FEGCAGLPRT VYVSDDTRFK VHTDGLVTVK RPVHLHRPEL SFLVHAWDST HRKLSTKVTL
     TVSAHHHHHH RHHDSLSGTQ TEVLTFPGSH HGLRRQKRDW VIPPISCPEN EKGPFPKSLV
     QIKSNKEKET QVFYSITGQG ADTPPVGVFI IERETGWLKV TQPLDREHIA KYILFSHAVS
     SNGQAIEEPM EIVITVTDQN DNKPQFTQEV FKGSVLEGAL PGTSVMQVTA TDIDDDVNTH
     NAAIGYKILA QEPMLPHNKM FTINKETGVI SVLTTGLDRE SFPTYTLMVQ AADLNGEGLS
     TTATAVITVL DANDNAPRFD PTTYMGSVPE NEANVAITTL TVTDADVPNT PAWEAVYTVL
     NDNEKQFIVI TDPVTNEGTL KTAKGLDFEA KQQYILYVAV TNVAPFEVTL PTSTATVTVD
     VIDVNEAPIF VPPQKKVEVP EDFGVGLEIT SYTAREPDTF MEQKIMYRIW RDAANWLEIN
     PETGAISTRA ELDREDVEHV KNSTYTALII ATDNGSPPAT GTGTLLLFLD DVNDNGPVPE
     PRAMDFCQRN PEPHIINIMD PDLPPNTSPF TAELTHGASV NWTIEYNDQE RESLILKPKK
     TLELGDHKIN LKLIDNQNKD QVTTLDVHVC DCDGIVSNCR KATPFAEAGL QVPAILGILG
     GVLAFLILIL LLLLLVRRRR VVKEPLLPPE DDTRDNVYYY DEEGGGEEDQ DFDLSQLHRG
     LDARPEVTRN DVAPTLMSVP QYRPRPANPD EIGNFIDENL KAADSDPTAP PYDSLLVFDY
     EGSGSEAASL SSLNSSESDQ DQDYDYLNEW GNRFKKLADM YGGGEDD
//
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