ID A0A452F3K0_CAPHI Unreviewed; 758 AA.
AC A0A452F3K0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=RUN and TBC1 domain-containing protein 3 {ECO:0000256|ARBA:ARBA00030864};
GN Name=SGSM3 {ECO:0000313|Ensembl:ENSCHIP00000018962.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000018962.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000018962.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000018962.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the small G protein signaling modulator family.
CC {ECO:0000256|ARBA:ARBA00006296}.
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DR EMBL; LWLT01000005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452F3K0; -.
DR STRING; 9925.ENSCHIP00000018962; -.
DR Ensembl; ENSCHIT00000026777.1; ENSCHIP00000018962.1; ENSCHIG00000018086.1.
DR GeneTree; ENSGT00940000157282; -.
DR Proteomes; UP000291000; Chromosome 5.
DR Bgee; ENSCHIG00000018086; Expressed in fallopian tube and 18 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005921; C:gap junction; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0048227; P:plasma membrane to endosome transport; IEA:Ensembl.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
DR GO; GO:0032486; P:Rap protein signal transduction; IEA:Ensembl.
DR GO; GO:0032483; P:regulation of Rab protein signal transduction; IEA:Ensembl.
DR CDD; cd17688; RUN_SGSM3; 1.
DR CDD; cd11813; SH3_SGSM3; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR035833; SGSM3_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47219:SF9; GTPASE ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF02759; RUN; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00593; RUN; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 117..313
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT DOMAIN 488..547
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 563..726
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
SQ SEQUENCE 758 AA; 85931 MW; 79FC972A4C5662EB CRC64;
MSGSHVPSAN GPFSALTPSM WPQEILAKCA QEAAEEQPEV RYDEFGFRVD KEGETEPLGD
ADGTPYSGQL LEDPPQRLRW QAHLEFTHNH DVGDLTWDKI AVSLPRSEKL RSLVLAGVPH
SMRPQLWMRL SGALQKKRNS ELSYREIVKN SSNDETIAAK QIEKDLLRTM PSNACFAHVS
GVGVPRLRRV LRALAWLYPE IGYCQGTGMR AARCLRGHLT LMGPVAACLL LFLEEDDDLL
PASYFSTTLL GVQTDQRVLR HLIVQYLPRL DRLLQEHDIE LSLITLHWFL TAFASVVHIR
LLLRLWDLFF YEGSLVLFQA TLGMLRLKED ELIQSENSAS IFNTLSDIPS QLEDADLLLA
EAMRLAGSLT AVAVEAQRRK HLAYLLADQG QLLGTTATAS LSQVVRRRTQ RRKAGITSLL
FGEDDLEAMK AKNIKQTELV ADLREAILRV ARHFQCTDPK NCNVELTPDY SMESHQRDHE
NYVACSRGHP RRAKALLDFE RHDDDELGFR KNDIITIVSQ KDEHCWVGEL NGLRGWFPAK
FVEVLDERSK EYSIAGDDAV TEGVTDLVRG TLCPALKALF EHGLKKPSLL GGACHPWLFI
EEAAGREVER DFDSVYSRLV LCKTYRLDED GKVLTPEELL YRAVQSVNVT HDAAHAQMDV
KLRSLICVGL NEQVLHLWLE VLCSSLPTVE KWYQPWSFLR SPGWVQIKCE LRVLCCFAFS
LSQDWELPAK REEEKKPLKE GVQDMLVKHH LFSWDIDG
//