GenomeNet

Database: UniProt
Entry: A0A452F3K0_CAPHI
LinkDB: A0A452F3K0_CAPHI
Original site: A0A452F3K0_CAPHI 
ID   A0A452F3K0_CAPHI        Unreviewed;       758 AA.
AC   A0A452F3K0;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=RUN and TBC1 domain-containing protein 3 {ECO:0000256|ARBA:ARBA00030864};
GN   Name=SGSM3 {ECO:0000313|Ensembl:ENSCHIP00000018962.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000018962.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Ensembl:ENSCHIP00000018962.1, ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000018962.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the small G protein signaling modulator family.
CC       {ECO:0000256|ARBA:ARBA00006296}.
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DR   EMBL; LWLT01000005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A452F3K0; -.
DR   STRING; 9925.ENSCHIP00000018962; -.
DR   Ensembl; ENSCHIT00000026777.1; ENSCHIP00000018962.1; ENSCHIG00000018086.1.
DR   GeneTree; ENSGT00940000157282; -.
DR   Proteomes; UP000291000; Chromosome 5.
DR   Bgee; ENSCHIG00000018086; Expressed in fallopian tube and 18 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005921; C:gap junction; IEA:Ensembl.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR   GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR   GO; GO:0048227; P:plasma membrane to endosome transport; IEA:Ensembl.
DR   GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
DR   GO; GO:0032486; P:Rap protein signal transduction; IEA:Ensembl.
DR   GO; GO:0032483; P:regulation of Rab protein signal transduction; IEA:Ensembl.
DR   CDD; cd17688; RUN_SGSM3; 1.
DR   CDD; cd11813; SH3_SGSM3; 1.
DR   Gene3D; 1.20.58.900; -; 1.
DR   Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR   InterPro; IPR000195; Rab-GAP-TBC_dom.
DR   InterPro; IPR035969; Rab-GAP_TBC_sf.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   InterPro; IPR035833; SGSM3_SH3.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR47219:SF9; GTPASE ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   Pfam; PF02759; RUN; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00593; RUN; 1.
DR   SMART; SM00326; SH3; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF140741; RUN domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR   PROSITE; PS50826; RUN; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          117..313
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000259|PROSITE:PS50086"
FT   DOMAIN          488..547
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          563..726
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
SQ   SEQUENCE   758 AA;  85931 MW;  79FC972A4C5662EB CRC64;
     MSGSHVPSAN GPFSALTPSM WPQEILAKCA QEAAEEQPEV RYDEFGFRVD KEGETEPLGD
     ADGTPYSGQL LEDPPQRLRW QAHLEFTHNH DVGDLTWDKI AVSLPRSEKL RSLVLAGVPH
     SMRPQLWMRL SGALQKKRNS ELSYREIVKN SSNDETIAAK QIEKDLLRTM PSNACFAHVS
     GVGVPRLRRV LRALAWLYPE IGYCQGTGMR AARCLRGHLT LMGPVAACLL LFLEEDDDLL
     PASYFSTTLL GVQTDQRVLR HLIVQYLPRL DRLLQEHDIE LSLITLHWFL TAFASVVHIR
     LLLRLWDLFF YEGSLVLFQA TLGMLRLKED ELIQSENSAS IFNTLSDIPS QLEDADLLLA
     EAMRLAGSLT AVAVEAQRRK HLAYLLADQG QLLGTTATAS LSQVVRRRTQ RRKAGITSLL
     FGEDDLEAMK AKNIKQTELV ADLREAILRV ARHFQCTDPK NCNVELTPDY SMESHQRDHE
     NYVACSRGHP RRAKALLDFE RHDDDELGFR KNDIITIVSQ KDEHCWVGEL NGLRGWFPAK
     FVEVLDERSK EYSIAGDDAV TEGVTDLVRG TLCPALKALF EHGLKKPSLL GGACHPWLFI
     EEAAGREVER DFDSVYSRLV LCKTYRLDED GKVLTPEELL YRAVQSVNVT HDAAHAQMDV
     KLRSLICVGL NEQVLHLWLE VLCSSLPTVE KWYQPWSFLR SPGWVQIKCE LRVLCCFAFS
     LSQDWELPAK REEEKKPLKE GVQDMLVKHH LFSWDIDG
//
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