ID A0A452F436_CAPHI Unreviewed; 1227 AA.
AC A0A452F436;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Sorbin and SH3 domain containing 2 {ECO:0000313|Ensembl:ENSCHIP00000019015.1};
GN Name=SORBS2 {ECO:0000313|Ensembl:ENSCHIP00000019015.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000019015.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000019015.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000019015.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452F436; -.
DR Ensembl; ENSCHIT00000026830.1; ENSCHIP00000019015.1; ENSCHIG00000018068.1.
DR GeneTree; ENSGT00940000157056; -.
DR Proteomes; UP000291000; Chromosome 27.
DR Bgee; ENSCHIG00000018068; Expressed in uterine horn and 17 other cell types or tissues.
DR CDD; cd11920; SH3_Sorbs2_1; 1.
DR CDD; cd11923; SH3_Sorbs2_2; 1.
DR CDD; cd11917; SH3_Sorbs2_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003127; SoHo_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR14167:SF56; DREBRIN-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF02208; Sorb; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 3.
DR SMART; SM00459; Sorb; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
DR PROSITE; PS50831; SOHO; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 143..204
FT /note="SoHo"
FT /evidence="ECO:0000259|PROSITE:PS50831"
FT DOMAIN 959..1018
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1034..1095
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1168..1227
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 25..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..258
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..962
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1227 AA; 138325 MW; CC9686313604E379 CRC64;
MNTDIGGCAR KRAAMSVTLT SVKRVQSSPN LLAAGRDSQS PDSAKGFRSV RPNLQEKKSP
AQSQITVNGN SGGTVSPMSY YQRPFSPSAY SLPGSLNSSL IMQHGRSLDS SEAYPQHAQS
LDGSMGSSIP LYRSSEEEKR VTVIKAPHYP GIGPVDESGI PTAIRTTVDR PKDWYKTMFK
QIHMVHKPDD DTDMYNTPYT YNAGLYNSPY STQSHPAAKT QTYRPLSKSH SDNGTNAFKD
ASSPVPPPPV PPPVPPFRAR DRSSTEKHDW DPPDRKVDTR KFRSEPRSIF EYEPGKSSIL
QHERPPPKKA LDYVQDHSPG VSNEASLYQS SIDRSLERPT SSASMASDFR KRRRSEPAVG
QPRGLGDPSA RSTSPGRADL PGSSTTLTKS FISSSPSSPS RAKGGDDSQT CPSLCSFSGL
NGHPSHELDY CNTYRQHLDV PQDSQRAITF KNGWQMARQN AEVWSSTEET VSPKIKSRSC
DDLLNDDCDS LPDPKTKSES MGSLLCEEDP KESCPVTWAS PYIQEGRSNG RSRLRHRSAH
DAPGFLKMYK KMHRINRKDL MNSEVICSVK SRIMQYEKEQ QHKGLLHGWS QSSTEEVPRD
MVPTRISEFE KLIQKSKSMP NLGDEMLSPV TLEPQQNGLC PQRRFSIESL LEEENQGRHP
SQVPRSYKSK ALVPIHIEVT SDDQPRTHVE FSDSDQDGVV SDHSDYIHVE GSSFCSESDF
DHFSFTSSES FYGSSHHHHH HHHHHHRHLI SSCKGRCPAS YTRFTTMLKH ERAKHENIDE
PRRQEMDPGL SKLAFLVSPV PFRRKKNSTP KKQMEKAKCK TSVFEALDSA LKDICDQIKA
EKRRGSLPDN SILHRLISEL LPDIPERNSS LRALKRSPMH QPFHPLPQEG AIHCPSYQND
CGRMPHSASF QDDTNNNYHH QDHTSALHLQ DHESPRNYSA TLTDLGRTAP RERRGTPEKE
KLPAKAVYDF KAQTSKELSF KKGDTVYILR KIDQNWYEGE HHGRVGIFPI SYVEKLTPPE
KAQPARPPPP AQPGEIGEAI AKYNFSADTN VELSLRKGDR IILLKRVDQN WYEGKIPGTN
RQGIFPVSYV EVVKKNTTKG AEDYPELPIP HSYSSDRIHS LSSNKILVLM LSLKRKETLL
RVQCTGNFYQ YFSSQPQRPV FTHENIQGGG EPFQALYNYT PRNEDELELR ESDVIDVMEK
CDDGWFVGTS RRTKFFGTFP GNYVKRL
//
