ID A0A452F4H7_CAPHI Unreviewed; 1013 AA.
AC A0A452F4H7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=RAS protein activator like 3 {ECO:0000313|Ensembl:ENSCHIP00000019074.1};
GN Name=RASAL3 {ECO:0000313|Ensembl:ENSCHIP00000019074.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000019074.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000019074.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000019074.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017906805.1; XM_018051316.1.
DR AlphaFoldDB; A0A452F4H7; -.
DR STRING; 9925.ENSCHIP00000019074; -.
DR Ensembl; ENSCHIT00000026889.1; ENSCHIP00000019074.1; ENSCHIG00000018235.1.
DR GeneID; 102187854; -.
DR KEGG; chx:102187854; -.
DR CTD; 64926; -.
DR GeneTree; ENSGT00940000161423; -.
DR OMA; ITRSYEW; -.
DR OrthoDB; 22721at2759; -.
DR Proteomes; UP000291000; Chromosome 7.
DR Bgee; ENSCHIG00000018235; Expressed in thymus and 15 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0098562; C:cytoplasmic side of membrane; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:Ensembl.
DR GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR CDD; cd13374; PH_RASAL3; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR PANTHER; PTHR10194:SF96; RAS PROTEIN ACTIVATOR LIKE-3; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 285..406
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 460..652
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 893..990
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1013 AA; 110723 MW; 37E08D2BDF3E9F07 CRC64;
MDPPSPSQAS QTQPAAPSPL TSYRWHSGGG GEKGAGGFRW GRLAGWGRAQ SHQETTASSQ
PAPRSLFRRV LSAPAKESRT SRLKISKSLW GKNKSPPLDS EPEPENPEPA PELEPLAAQI
PEAPTPDVPV WNIEAFTLLD GKLVLLGNEE EGPRQPRIGS ASSESSIQVA LGNLKDPDRT
PGKTEPEAAG PHQIHNVRGL LKRLKEKKKA KSELGASASR DGPPSALGSR ESLATISELD
LGAERDVRVW PLHRSLLEEP HCFQVTWAGG SRCFSCRSAA ERDRWIEDLR RHFQPSQDNV
EREETWLSVW VHEVKGLPRA AAAAAPGVRA ELWLDGALLA RTTPRAGPGQ LFWAERFHFE
ALPPARRLSL RLRGAGPGDA VLGRVALALE ELSVPRAPAA GLERWFPLLG APAGAALRAR
IRARRLRVLP SERYKELAEF LTFHYARLCG ALELALSAQA KEELAAAMVR VLRATGRAQA
LVTDLGTAEL ARSGGREALL FRENTLATKA IDEYMKLVAQ DYLQETLGQV VRRLCASTED
CEVDPSKCPA SDLPQHQSRL RNSCKEVFEN IIHSYNWFPA ELGTVFSGWR EACKARGSEA
LGPRLVCASL FLRLLCPAIL SPSLFGLASE HPAPGPARTL TLIAKVIQNL ANRAPFGEKE
AYMSFMNSFL EDHGPAMQHF LDQVAMVDAD TAPSGYQGSS DLALQLAVLH AQLCTIFAEL
DQATRDNLEP LPTILHAIEE GRPVPVTVPM CFPAPHTQGH SSISAGEKPG FLAPRDLPKH
TPLISKSQSL RSVHGAGSWA RPRLEEEQPP RLPRPVQRTQ SVPAGRPARR RPSAGPRPRP
KGSLQAGPAP RGRPWTGASA SLPRKPSVPW QRQMDQPRDK DQALGTHRPV GKLAELQCEV
AALRQDLKML SGLVESLSTH IRSLSEQQEQ LRTQLQLLDS RLREGTVKLD PGRDPSTNES
HRLKSLECRL AEIESTQAQL KDTIQNLQLL PRTSESQSQP LPLKAPCING DTT
//
