ID A0A452F565_CAPHI Unreviewed; 795 AA.
AC A0A452F565;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Potassium voltage-gated channel subfamily Q member 5 {ECO:0000313|Ensembl:ENSCHIP00000019309.1};
GN Name=KCNQ5 {ECO:0000313|Ensembl:ENSCHIP00000019309.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000019309.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000019309.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000019309.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; LWLT01000011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452F565; -.
DR Ensembl; ENSCHIT00000027124.1; ENSCHIP00000019309.1; ENSCHIG00000018348.1.
DR GeneTree; ENSGT00940000155933; -.
DR OMA; HKQKLFR; -.
DR Proteomes; UP000291000; Chromosome 14.
DR Bgee; ENSCHIG00000018348; Expressed in frontal cortex and 8 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR PANTHER; PTHR47735:SF8; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 18..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..219
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 328..515
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 303..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 795 AA; 86184 MW; 68071B9657FF7328 CRC64;
FGCLILSVFS TIPEHTKLAS SCLLILEFVM IVVFGLEFII RIWSAGCCCR YRGWQGRLRF
ARKPFCVIDT IVLIASIAVV SAKTQGNIFA TSALRSLRFL QILRMVRMDR RGGTWKLLGS
VVYAHSKELI TAWYIGFLVL IFSSFLVYLV EKDANKEFST YADALWWGTI TLTTIGYGDK
TPLTWLGRLL SAGFALLGIS FFALPAGILG SGFALKVQEQ HRQKHFEKRR NPAANLIQCV
WRSYAADEKS VSVATWKPHL KALHTCSPTN CCLPLTPSQV CSHKQKLFRI HTSWKQSQKL
SFKERVRMAS PRGQSVKSRQ ASLGDRRSPS TDITAEGSPT KVQKSWSFND RTRFRPSLRL
KSSQPKPVVD ADTALGTDDV YDDKGCQCDV SVEDLTPPLK TVIRAIRIMK FHVAKRKFKE
TLRPYDVKDV IEQYSAGHLD MLCRIKSLQT RVDQILGKGQ ITSDKKSREK ITAEHEATDD
LSMLGRVVKV EKQVQSIEAK LDCLLDIYQQ VLRKGSAPTL ALAPFPSPPF ECEQTSDYQS
PGDGRDLSGP APGGGLPRSA SAGLARGLQL ILAPGELGAQ ALYAFSPAPT PAPGSPGDGP
AAPRGLAPPG AVGAARPAAP ATLQIPAALP VLGPLPHGPA GAPEALPELS ARPAAAKDRL
PAKERSLRQS LDLGGAALLS VRPAVPQDPG RSVSAQNLAR STEDLDVQLS GSESSGSRGS
QEFYPKWRES KLFISDEEAA GPEDTGTDAL DAVPPAREPA PAPDSLRTGR SRSSQSSCPA
AGGADALGRP HVRLK
//
