ID A0A452F5J8_CAPHI Unreviewed; 332 AA.
AC A0A452F5J8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Spondin 2 {ECO:0000313|Ensembl:ENSCHIP00000019643.1};
GN Name=SPON2 {ECO:0000313|Ensembl:ENSCHIP00000019643.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000019643.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000019643.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000019643.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; LWLT01000006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017905364.1; XM_018049875.1.
DR AlphaFoldDB; A0A452F5J8; -.
DR STRING; 9925.ENSCHIP00000019643; -.
DR Ensembl; ENSCHIT00000027458.1; ENSCHIP00000019643.1; ENSCHIG00000018579.1.
DR GeneID; 108636248; -.
DR KEGG; chx:108636248; -.
DR CTD; 10417; -.
DR GeneTree; ENSGT00940000159900; -.
DR OMA; PQDRITQ; -.
DR OrthoDB; 5404502at2759; -.
DR Proteomes; UP000291000; Chromosome 6.
DR Bgee; ENSCHIG00000018579; Expressed in uterine horn and 16 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.2130; F-spondin domain; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR009465; Spondin_N.
DR InterPro; IPR038678; Spondin_N_sf.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR044004; TSP1_spondin_dom.
DR NCBIfam; NF038123; NF038123_dom; 1.
DR PANTHER; PTHR11311; SPONDIN; 1.
DR PANTHER; PTHR11311:SF32; TSP1_SPONDIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF06468; Spond_N; 1.
DR Pfam; PF19028; TSP1_spondin; 1.
DR SMART; SM00209; TSP1; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS51020; SPONDIN; 1.
DR PROSITE; PS50092; TSP1; 1.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..332
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019534269"
FT DOMAIN 32..222
FT /note="Spondin"
FT /evidence="ECO:0000259|PROSITE:PS51020"
SQ SEQUENCE 332 AA; 35710 MW; 2F2EFFE6CCD4DB56 CRC64;
MGAPRPVFPR GAALWAFLLA SLGGVAGQPL GAEPTCTAQP LARYSVTFTG KWSQASFPKQ
YPLFRPPAQW SSLLGAAHSS DYSLWRKDQY VSNGLREFAE RGEAWALVRE MEAAGERLQS
VHGVFSAPAV PSGTGQTSAE LEAHSRHSLV SFVVRIVPSP DWFVGVDSLD LCDRGSWREQ
VAVDLYPYDA GTDSGFTFSS PNFATVPQDT VTEITASSPS HPANSFYYPR LKALPPIARV
VLVRLRQSPR AFSPPALGLG AGGNEIVDSL PDPETPLDCE VSLWSSWGLC AGPCGRPGAK
SRTRYVRVRP ANHGAPCPAL EEEAPCDPDN CV
//
