ID A0A452F6R8_CAPHI Unreviewed; 929 AA.
AC A0A452F6R8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Protocadherin gamma subfamily C, 4 {ECO:0000313|Ensembl:ENSCHIP00000019831.1};
GN Name=PCDHGC4 {ECO:0000313|Ensembl:ENSCHIP00000019831.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000019831.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000019831.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000019831.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain. {ECO:0000256|ARBA:ARBA00003436}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; LWLT01000008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452F6R8; -.
DR Ensembl; ENSCHIT00000027654.1; ENSCHIP00000019831.1; ENSCHIG00000018689.1.
DR GeneTree; ENSGT00940000162232; -.
DR Proteomes; UP000291000; Chromosome 7.
DR Bgee; ENSCHIG00000018689; Expressed in cerebellum and 16 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF66; PROTOCADHERIN GAMMA-B6; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..929
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019225974"
FT TRANSMEM 689..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 75..132
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 133..241
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 242..346
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 354..451
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 452..561
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 576..674
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 797..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 929 AA; 100712 MW; 4862E255A9F2631C CRC64;
MGGSCTQTRP ADRRQVLFLF LLPLFYPALC QQIRYSIPEE LAKGSVVGNL ARDLGLSVLD
VSARKLRVSA EKPLFNVDAE SGDLLVKDRI DREEICKERR CELQLEAVVE NPLNIFHIIV
VVEDINDHAP QFDKKKIHLD IFESVSAGAR ISLHPATDPD INMNSVKDYQ INPNPYFSLM
VRVNSDGGRY PELSLEKPLD REEQRSHSLI LTAWDGGDPP RSATAQIEIS VKDTNDNPPV
FSQDEYRLSV SENLPPGSSV LLVTATDQDE GANAEINYYF RSTAQSTRHK FSLDEKTGMI
KNNQSLDFED IERYTMEVEA KDGGGLSSQC KVIIDILDEN DNIPEIIVTS LSDQILEGSL
PGMVVALFKT RDRDSGGNGE VTCHVGRDVP FKISSSSNNY YKLVTDGDLD REQTPEYNVT
ITATDRGKPP LSSSTTITLH ITDINDNAPV FHQASYIVHV GENNPPGAPI AQVSASDPDL
GPNGHVSYSI VASDLQPRAL SSYVSVNPQS GVVFAQRAFD HEQLRAFELT LQARDHGSPA
LSANVSLRVL VGDRNDNAPR VLYPALGPDG SALFDTVPRA AQPGYLVTKV VAVDADSGHN
AWLSYHVLQA SEPGLFSVGL RTGEVRTARV LGDRDAARQR LLVAVRDGGQ PPLSATATLL
LIFADSLQEA LPDLSDRPAP PDPQAELQFY LVVALALISV LFLLAVILAV ALHLRLSSSP
AAWGCFKPDL CVKSGPVVPR NYSEGTLPYS YNLCVAHTGK TEFNFLRCSE PLHPTQDIVC
GDSPGALIPL HSGNDLATHP ETLTPQAPPN TDWRFSQAQR PGTSGSQNGD ETGTWPNNQF
DTEMLQAMIL ASASEAADGS STLGGGAGTM GLSARYGPQF TLQHVPDYRQ NVYIPGSNAT
LTNAAGKRDG KAPAGGNGNK KKSGKKEKK
//
