ID A0A452F746_CAPHI Unreviewed; 207 AA.
AC A0A452F746;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Protein lin-7 homolog {ECO:0000256|PIRNR:PIRNR038039};
GN Name=LIN7B {ECO:0000313|Ensembl:ENSCHIP00000020081.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000020081.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000020081.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000020081.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in establishing and maintaining the asymmetric
CC distribution of channels and receptors at the plasma membrane of
CC polarized cells. {ECO:0000256|PIRNR:PIRNR038039}.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004171}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004171}. Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|PIRNR:PIRNR038039};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202,
CC ECO:0000256|PIRNR:PIRNR038039}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00023767}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00023767}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Postsynaptic density membrane
CC {ECO:0000256|ARBA:ARBA00034098}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00034098}.
CC -!- SIMILARITY: Belongs to the lin-7 family.
CC {ECO:0000256|ARBA:ARBA00008546, ECO:0000256|PIRNR:PIRNR038039}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LWLT01000020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017918249.1; XM_018062760.1.
DR STRING; 9925.ENSCHIP00000020081; -.
DR Ensembl; ENSCHIT00000027910.1; ENSCHIP00000020081.1; ENSCHIG00000018852.1.
DR Ensembl; ENSCHIT00010039214.1; ENSCHIP00010027782.1; ENSCHIG00010020620.1.
DR GeneID; 102181892; -.
DR CTD; 64130; -.
DR GeneTree; ENSGT00940000153222; -.
DR OMA; PLGLERX; -.
DR OrthoDB; 4175920at2759; -.
DR Proteomes; UP000291000; Chromosome 18.
DR Proteomes; UP000694566; Chromosome 18.
DR Bgee; ENSCHIG00000018852; Expressed in frontal cortex and 18 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0097025; C:MPP7-DLG1-LIN7 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098793; C:presynapse; IEA:UniProtKB-UniRule.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-UniRule.
DR GO; GO:0007269; P:neurotransmitter secretion; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 1.20.1270.460; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR017365; LIN7.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR14063; PROTEIN LIN-7 HOMOLOG; 1.
DR PANTHER; PTHR14063:SF7; PROTEIN LIN-7 HOMOLOG B; 1.
DR Pfam; PF02828; L27; 1.
DR Pfam; PF00595; PDZ; 1.
DR PIRSF; PIRSF038039; Lin-7_homologue; 2.
DR SMART; SM00569; L27; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|PIRNR:PIRNR038039};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR038039};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483, ECO:0000256|PIRNR:PIRNR038039};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038039};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR038039};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR038039}.
FT DOMAIN 10..65
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 93..175
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 187..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 207 AA; 22910 MW; 9619D876C09FDEF4 CRC64;
MAALVEPLGL EREVSRAVEL LERLQRSGEL PPQKLQALQR VLQSRFCSAI REVYEQLYDT
LDITGSAEIR AHATAKATVA AFTASEGHAH PRVVELPKTD EGLGFNIMGG KEQNSPIYIS
RVIPGGVADR HGGLKRGDQL LSVNGVSVEG EQHEKAVELL KAAQGSVKLV VRYTPRVLEE
MEARFEKMRS ARRRQQHQSY SSLESRG
//
