ID   A0A452FAG3_CAPHI        Unreviewed;       897 AA.
AC   A0A452FAG3;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=NEDD4-binding protein 1 {ECO:0000256|ARBA:ARBA00039336};
GN   Name=N4BP1 {ECO:0000313|Ensembl:ENSCHIP00000021259.1};
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000021259.1, ECO:0000313|Proteomes:UP000291000};
RN   [1] {ECO:0000313|Ensembl:ENSCHIP00000021259.1, ECO:0000313|Proteomes:UP000291000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA   Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA   Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA   Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA   Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT   "Polished mammalian reference genomes with single-molecule sequencing and
RT   chromosome conformation capture applied to the Capra hircus genome.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCHIP00000021259.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus, PML body
CC       {ECO:0000256|ARBA:ARBA00004322}. Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
CC   -!- SIMILARITY: Belongs to the N4BP1 family.
CC       {ECO:0000256|ARBA:ARBA00038274}.
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DR   EMBL; LWLT01000020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_017917446.1; XM_018061957.1.
DR   AlphaFoldDB; A0A452FAG3; -.
DR   STRING; 9925.ENSCHIP00000021259; -.
DR   Ensembl; ENSCHIT00000029102.1; ENSCHIP00000021259.1; ENSCHIG00000019641.1.
DR   GeneID; 102177272; -.
DR   KEGG; chx:102177272; -.
DR   CTD; 9683; -.
DR   GeneTree; ENSGT00940000158682; -.
DR   OrthoDB; 180910at2759; -.
DR   Proteomes; UP000291000; Chromosome 18.
DR   Bgee; ENSCHIG00000019641; Expressed in longissimus thoracis muscle and 17 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016605; C:PML body; IEA:Ensembl.
DR   GO; GO:0003729; F:mRNA binding; IEA:Ensembl.
DR   GO; GO:0004540; F:RNA nuclease activity; IEA:Ensembl.
DR   GO; GO:0043130; F:ubiquitin binding; IEA:Ensembl.
DR   GO; GO:0034644; P:cellular response to UV; IEA:Ensembl.
DR   GO; GO:0001818; P:negative regulation of cytokine production; IEA:Ensembl.
DR   GO; GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   GO; GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
DR   GO; GO:0045071; P:negative regulation of viral genome replication; IEA:Ensembl.
DR   GO; GO:0045088; P:regulation of innate immune response; IEA:Ensembl.
DR   CDD; cd22476; KH-I_N4BP1; 1.
DR   CDD; cd09032; KH-I_N4BP1_like_rpt1; 1.
DR   CDD; cd18728; PIN_N4BP1-like; 1.
DR   Gene3D; 3.40.50.11980; -; 1.
DR   InterPro; IPR021869; RNase_Zc3h12_NYN.
DR   PANTHER; PTHR12876; N4BP1-RELATED; 1.
DR   PANTHER; PTHR12876:SF26; NEDD4-BINDING PROTEIN 1; 1.
DR   Pfam; PF11977; RNase_Zc3h12a; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT   DOMAIN          618..770
FT                   /note="RNase NYN"
FT                   /evidence="ECO:0000259|Pfam:PF11977"
FT   REGION          802..821
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   897 AA;  100412 MW;  1B01A84837C59A55 CRC64;
     MAARAVLDEF TAPAEKAALL ERSRGRIEGL FGVSLAVLGA LGAEEPLPAR IWLQLRGAQE
     AVHSAKEYIK GICEPELEER ECYPKAMHCI FVGAQSLFLK SLIQDTCADL CILDIGLLGI
     RGSAEAVVMA RSHIQQFVKL FENNENLPNS QKESEVKREF KQFVEARADS YTMDLLILPT
     SLKKELLALT QGEENLFETG DDDDVEIRDS TQGEFTQNAA TGLTISRDEI VLQEDARNKA
     GTPVSELTKQ MDTVFSSSQD VLFVPMNGVT PDEEALSKDR VCHKRRFSDS EERHTKKQFS
     LENVEEGGLL HDGKTLAGRV ITDVSDSSTE AENLSPDIKD TTEEMEYNIL VNFFKTMGYS
     QEIVEKVIRE YGPSTEPLLL LEEIEKENKR FQGDREFSPG SVYPETNRTK NKGVCSSINE
     LAADSTPKKT QTHTQQNMVE NFSQLPFRVE SKPCTSNCKM DTFRTVPIEQ KQEIWSSNQS
     YICNIDLETD GLLPSVVPSS PKEVVSFVSR GASSHQPRIP VFPENGLQQQ AEPLLPNSVK
     SASENRSRCC SSPQSKPGCP PLSPPMPLSQ LLPSVTDARL AGPSEHIDCS VTGVQRFRDT
     LKVPYKLELK NEPGRTDLKH IVIDGSNVAI THGLKKFFSC RGIAIAVEYF WKLGNRNITV
     FVPQWRTRRD PNVTEQHFLT QLQELGILSL TPARMVFGER IASHDDRFLL HLADKTGGII
     VTNDNFREFV TESVSWREII TKRLLQYTFV GDIFMVPDDP LGRSGPRLEE FLRKEVFLRD
     MQPLLNALPN VGMFDPSFRV PGAQAASTSH QPPARIQGTP PSHWLPQQPR FPLLPNLPNI
     QQNLPMPAQR SPAETNELRE ALLKIFPDSE QKLKIDQILA AHPYMKDLNA LSAMVLD
//