ID A0A452FBU7_CAPHI Unreviewed; 1686 AA.
AC A0A452FBU7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Myosin VC {ECO:0000313|Ensembl:ENSCHIP00000021726.1};
GN Name=MYO5C {ECO:0000313|Ensembl:ENSCHIP00000021726.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000021726.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000021726.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000021726.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; LWLT01000010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9925.ENSCHIP00000021726; -.
DR Ensembl; ENSCHIT00000029580.1; ENSCHIP00000021726.1; ENSCHIG00000019938.1.
DR GeneTree; ENSGT00940000157971; -.
DR OMA; EIMFDDR; -.
DR Proteomes; UP000291000; Chromosome 10.
DR Bgee; ENSCHIG00000019938; Expressed in descending colon and 16 other cell types or tissues.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd15476; Myo5c_CBD; 1.
DR CDD; cd01380; MYSc_Myo5; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 6.10.220.10; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR037991; Myo5c_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR036103; MYSc_Myo5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF313; UNCONVENTIONAL MYOSIN-VC; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00015; IQ; 5.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 1..54
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 59..720
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1365..1641
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT COILED 851..1065
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1178..1318
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 153..160
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1686 AA; 196411 MW; 3433E963C2770373 CRC64;
QYNRVWIPDS EEVWKSAEIA KDYRVGDKVL QLLLEDGTEL DYSVDPECLP PLRNPDILVG
ENDLTALSYL HEPAVLHNLR IRFAESKLIY TYSGIILVAM NPYKQLPIYG DPIIHAYSGQ
NMGDMDPHIF AVAEEAYKQM ARNNKNQSII VSGESGAGKT VSARYAMRYF ATVSKSGSNA
HVEDKVLASN PITEAVGNAK TTRNDNSSRF GKYTEISFDE RNQIIGANMR TYLLEKSRVV
FQSENERNYH IFYQLCASAQ QSEFKHLKLG SAEEFNYTRM GGSTVLEGVN DRANMIETQK
TFTLLGFKED FQMDVFKVLA AILHLGNVQI AAVGNERSVI SEDDGHLEVF CELLGLDSGR
VAQWLCNRKI VTTSETVVKP MTRPQAVNAR DALAKKIYAH LFDFIVERIN QALQFSGKQH
TFIGVLDIYG FETFDVNSFE QFCINYANEK LQQQFNLHVF KLEQEEYMKE DIPWTLIDFY
DNQPVIDLIE AKMGILELLD EECLLPHGTD ENWLQKLYNN FVNKNSLFEK PRMSNTSFII
QHFADKVEYK CEGFLEKNRD TVYDMLVEIL RASKFHLCAN FFQENPVPSS PFGSAITVKS
AKPVIKPNNK HFRSTVGSLL YCFWACLFDS KRIVQQLRAC GVLETIRISA QSYPSRWTYI
EFYSRYGILM TKQELSFSDK KEVCKVVLHR LIQDSNQYQF GKTKIFFRAG QVAYLEKLRL
DKLRQGCIVI QKHVRGWLQR KKFLRERRAA LIIQQYFRGQ QTVRKAVTAT ALKEAWAAIV
IQKYCRAYLV RNLYQLIRVA TITIQAYTRG FLARRRYQKM LKEHKAMILQ KYARAWLARR
RFQNIRRFVL NIQLTYRVQR LQKKLEDQNK ENHGLVEKLT SLAALRAGDV EKIQKLESEL
DRAAAHRQNY EEKGMRYRAS VEEKLAKLQK HNSELEIQKE QIQLKLQEKT EELKEKMDNL
TKQLFDDVQK EEQQRVLLEK SFELKTQDYE KQIRSLKEEI KALKDEKMQL QCQLEEERVT
SDGLKGEVAR LSKQAKTISE FEKEIELLQT QKIDVEKHVQ SQKREMREKM SEITRQLLES
YDIEDVRSRL SLEDLEHLNE DGELWFAYEG LKKATRVLEN HFQSQKDCYE KEIEALNFKV
VHLSQEINHL QKLFREENDI NESIRHEVTR LTSENMMIPD FKQQISELEK QKRDLEIRLN
EQTETMKGKL EELSNQLNHN REEEGTQRKT VEAQNEIHTK EKEKLMDKIQ EIQEASEHLR
KQFETENEVK SSFQQEASRL TMEKRDLEEE LDMKERVIKK LQDQVKTLTK TIEKEKWTSP
PIIIDLKPRG VVVNMIPGLP AHILFMCVRY ADSLNDADML KSLMNSTISG IKQVVKEHLE
DFEMLSFWLS NTCHFLNCLK QYSGEEEFMK HNSPHQNKNC LNNFDLSEYR QILSDVAIRI
YHQFIIVMEN NIQPIIVPGM LEYESLQGIS GLKPTGFRKR SSSIDDTDAY TVASVLQQLS
YFYSTMCQNG LDPEIVRQAV KQLFFLIGAV TLNSLFLRKD MCSCRKGMQI RCNISYLEEW
LKDKNLQNNL AKETLEPLSQ AAWLLQVKKT TDSDAKEIYE RCTSLSAVQI IKILNSYTPI
DDFEKRVTPS FVRKVQALLA SREDSSHLML DTKYLFQVTF PFTPSPHALE MIQIPSSFKL
GFLNRL
//
