ID A0A452FC48_CAPHI Unreviewed; 731 AA.
AC A0A452FC48;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Tudor domain-containing protein 3 {ECO:0000256|ARBA:ARBA00013421};
GN Name=TDRD3 {ECO:0000313|Ensembl:ENSCHIP00000021835.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000021835.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000021835.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000021835.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LWLT01000013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452FC48; -.
DR Ensembl; ENSCHIT00000029692.1; ENSCHIP00000021835.1; ENSCHIG00000020019.1.
DR GeneTree; ENSGT00940000155487; -.
DR Proteomes; UP000291000; Chromosome 12.
DR Bgee; ENSCHIG00000020019; Expressed in testis and 17 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd20413; Tudor_TDRD3; 1.
DR CDD; cd14282; UBA_TDRD3; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 2.40.50.770; RecQ-mediated genome instability protein Rmi1, C-terminal domain; 1.
DR InterPro; IPR042470; RMI1_N_C_sf.
DR InterPro; IPR013894; RMI1_OB.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR047379; Tudor_TDRD3.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR041915; UBA_TDRD3.
DR PANTHER; PTHR13681; SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED; 1.
DR PANTHER; PTHR13681:SF24; TUDOR DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF08585; RMI1_N_C; 1.
DR Pfam; PF00567; TUDOR; 1.
DR Pfam; PF00627; UBA; 1.
DR SMART; SM01161; DUF1767; 1.
DR SMART; SM00333; TUDOR; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50304; TUDOR; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 273..313
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 635..695
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT REGION 314..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..535
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 731 AA; 81973 MW; 7FC5181601AC0B2F CRC64;
FSPFNEGIEA CTSSPDKVNV NDIILIALNT DLRTIGKKFL PSDINGGKVE KLEGPCVLQI
QKIRNVAAPK DNEESQAAPR MLRLQMTDGH ISCTAVEFSY LSKISLNTPP GTKVKLSGAV
DVKNGFLLLN DSNTTVLGGE VEHLIEKWEL QRSLSKHNRS NIGTEGGPPP FVPFGQKCVS
HIQVDSRELD RRKTLQVTMP VKPPNDNDEF EKQRTAAIAE VAKSKETKTF GGGGGGARSN
LNMSAAGNRN REILQKEKAN KSEGKHEGVY RELVDEKALR HITEMGFSKE ASRQALMDNG
NNLEAALNVL LNSNKQKPVM GPPLRGKGKG RGRIRSEDEE ELGNARPSAP STLFDFLESK
MGTLSMEEPK SQPQQLHQGQ NRMSNTEQNG VKDNNQPRYL PRNDIRQPRN EKPPRFQRDT
QNSKAVLEGS GLPRNRGSER PSTSSGSEVW AEERIKCDRS YSRYDRTKDT SYLLSSPHSD
TVFTKRDNCM QSRSGKGPSY AEAKENPFPQ ESIDYNNHKR GKRENQTANS DHFYDRKPRT
VNNEAFSGVK IEKHFNINTE HQNPVRTNSF IGVPNGETEM PLKGRRVGPI KPAGPITASS
YDDKIFYSSG PKRRSGPIKP EKVLESSIPM EYAKLWKSGD ECLALYWEDN KFYRAEVEAL
HSSGMTAVVK FIDYGNYEEV LLSNMRPIQS EAWEEEGTYD QTLEFRRGGD GQPRRSTRPT
QQFYQPPRAR N
//
