ID A0A452FEW4_CAPHI Unreviewed; 1297 AA.
AC A0A452FEW4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Tubulin--tyrosine ligase-like protein 5 {ECO:0000256|ARBA:ARBA00041448};
GN Name=TTLL5 {ECO:0000313|Ensembl:ENSCHIP00000022821.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000022821.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000022821.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000022821.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-glutamate + L-glutamyl-[protein] = ADP + gamma-L-
CC glutamyl-L-glutamyl-[protein] + H(+) + phosphate;
CC Xref=Rhea:RHEA:60144, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15517,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29973, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143622,
CC ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00036640};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60145;
CC Evidence={ECO:0000256|ARBA:ARBA00036640};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; LWLT01000010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCHIT00000030681.1; ENSCHIP00000022821.1; ENSCHIG00000020468.1.
DR GeneTree; ENSGT00940000162939; -.
DR Proteomes; UP000291000; Chromosome 10.
DR Bgee; ENSCHIG00000020468; Expressed in fallopian tube and 17 other cell types or tissues.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR004344; TTL/TTLL_fam.
DR PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR PANTHER; PTHR12241:SF145; TUBULIN POLYGLUTAMYLASE TTLL5; 1.
DR Pfam; PF03133; TTL; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS51221; TTL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1005..1043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1088..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1217..1265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1277..1297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..619
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..795
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1005..1023
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1088..1129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1297 AA; 145313 MW; FFB909A412D23740 CRC64;
MPVVMARDLE ETASSSEDEE VVSQEDHPCI MWTGGCRRIP VLVFHAEAIL TKDNNIRVIG
ERYHLSYKIV RTDSRLVRSI LTAHGFHEVH PSSTDYNLMW TGSHLKPFLL RTLSEAQKVN
HFPRSYELTR KDRLYKNIIR MQHTHGFKAF HILPQTFLLP AEYAEFCTDS YSKDRGPWIV
KPVASSRGRG VYLINNPNQI SLEENILVSR YINNPLLIDD FKFDVRLYVL VTSYDPLVIY
LYEEGLARFA TVRYDQGAKN IRNQFMHLTN YSVNKKSGDY VSCDDPEVED YGNKWSMSAM
LRYLKQEGRD TTALMAHVED LIIKTIISAE LAIATACKTF VPHRSSCFEL YGFDVLIDST
LKPWLLEVNL SPSLACDAPL DLKIKASMIS DMFTVVGFVC QDPAQRTSTR PIYPTFESSR
RNPFQKPQRP VSAQFQSSTV KQRSRPLSAS DAEMKNLVGS AREKVPGKLG GSVLGLSMEE
IKVLRRVKEE NDRRGGFIRI FPTSETWEIY GSYLEHKTSM NYMLATRLFQ DRMAIDGAPE
LKVESMNSRA KLHAALYERK LLSLEVRKRR RRSGRLRAMR PKYPVITQPA EMNVKTETES
EEEEEVALDT EDEEQEAYQE ESAGSLGENQ AKYTPSLTVM IENSPKENAM KVPELNNKGE
QCCKMETQEP EPKFNLMQIL QDNGNLSKVQ ARIAFSAYLQ HVQIRLMKDS GGQTFSASWA
AKEDEQMELV VRFLKRASSN LQHSLRMVLP SRRLALLERR RILAHQLGDF ISVYNKETEQ
MADKKSKKKL EEEEEDGVNS ENFQDFIRQA SEAELEEVLT FYTQKNKSAS VFLGTHSKSS
KNSNSFSDSG AKGDHPETME EVKIKQPKQQ QTTEIHSDKL SRFTTSAEKE AKLIYTNSST
SFSGPAATLL QKIPNTHLSS IVTTPDLSPG PGHHSLSQIP PAIPSMPHQP AVLLSTVPDS
AALSMHPGTQ NVPSPAGLPR CRSGSYTIGP FSSFQSAAHI YSQKLSRPSS AKAGSCHPNK
QHSGVARTQK EGEDGSSYSK RYNPSMVTAE LQRLAEKQAA RQYSPSTHIS LLTQQVTNLN
LASSVINRSS ASTPPTLRPV ISPSGPTWSI QSDPQAPESH CTPPGSRSLQ TGGFAWEGEV
ENNAYSKATG VAPQHKYHPT AGSYQLHFAL QQLEQQKLQS RQLLDQSRAR HQAIFGSQTL
PNSNLWTINN GAACRIPSAT ASGQKPTTLP QKVVPPPSSS SSLVPKPPSN HKQVLRKATS
QRASNLTCKT RLLKPACSEP LLSNKRSHPS EKSSCRN
//
