ID A0A452FF09_CAPHI Unreviewed; 652 AA.
AC A0A452FF09;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=G-protein coupled receptors family 2 profile 2 domain-containing protein {ECO:0000259|PROSITE:PS50261};
GN Name=ADGRF2 {ECO:0000313|Ensembl:ENSCHIP00000023004.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000023004.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000023004.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000023004.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR EMBL; LWLT01000028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005696443.2; XM_005696386.3.
DR AlphaFoldDB; A0A452FF09; -.
DR Ensembl; ENSCHIT00000030864.1; ENSCHIP00000023004.1; ENSCHIG00000020762.1.
DR GeneID; 102187087; -.
DR CTD; 222611; -.
DR GeneTree; ENSGT00940000162401; -.
DR OMA; MLMQKCP; -.
DR OrthoDB; 3876300at2759; -.
DR Proteomes; UP000291000; Chromosome 23.
DR Bgee; ENSCHIG00000020762; Expressed in rumen and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15994; 7tmB2_GPR111_115; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008078; GPCR_2_Ig-hepta-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR45813:SF6; ADHESION G-PROTEIN COUPLED RECEPTOR F2; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01695; IGHEPTARCPTR.
DR SMART; SM00303; GPS; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 359..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 594..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 360..615
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 71920 MW; 53C62FB6FC409032 CRC64;
MQRALNEAAN KSKEQVSTRP HGECHGTCVD NSYCSQPCPP DTPGDMGFLC RQKKWRKVTD
TCRTLTAFNI FEADLNSVQT FGGSKISEYT NKPETITDLL MEKCPQDLSC VIRNIQKSPR
IPGNIAVIVQ LLHNISTVPM TDVDEAKMQS YSIIANHILN SKSISNWTFI PERNSSCVLL
HSINSFARKL FVNKHPIDIA DTFIHTVGTI LSRDNAGKNF TFSMRVNDTS DMVTGKVLIS
REELQEVPSP SQAVSIAFPT LGAILEASVL ESITVNGLVL SVILPKELEK ISLIFEKISK
SEDRTAQCVG WHSLEGRWDR KVCQMIEENS QQAVCNCSPS KAFTSFSILM APHVLQSPIL
IYITYIGLGV SICSLILCLS IEALVWGQVT KTEISYLRHV CIANIATTLL MADVWFVVAS
FLSGPTKHHS ACVAATFFVH FFYLSVFFWM LAKALLILYG ILIVFHTLPK SVLVAALFAV
GYGGPLLIAA ITVAATEPGN GYLRPEACWL NWDMTKALLA FVVPALAIVV VNLVTVTLVI
VKTRRAAMGS SMFQEVRAIV RISKNIAILT PLLGLTWGFG IATVLNDGSL ACHIIFSLLN
AFQGFFILVF GTILDPKIRD ALKDRINSAQ WISRISENVS SDFSRHPTKV PR
//
