ID A0A452FG37_CAPHI Unreviewed; 1695 AA.
AC A0A452FG37;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Tenascin C {ECO:0000313|Ensembl:ENSCHIP00000023328.1};
GN Name=TNC {ECO:0000313|Ensembl:ENSCHIP00000023328.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000023328.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000023328.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000023328.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the tenascin family.
CC {ECO:0000256|ARBA:ARBA00008673}.
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DR EMBL; LWLT01000007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; A0A452FG37; -.
DR Ensembl; ENSCHIT00000031188.1; ENSCHIP00000023328.1; ENSCHIG00000020744.1.
DR GeneTree; ENSGT00940000155188; -.
DR Proteomes; UP000291000; Chromosome 8.
DR Bgee; ENSCHIG00000020744; Expressed in spleen and 16 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 9.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 2.20.25.10; -; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR041161; EGF_Tenascin.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR PANTHER; PTHR46708:SF1; TENASCIN; 1.
DR Pfam; PF07974; EGF_2; 6.
DR Pfam; PF18720; EGF_Tenascin; 7.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR Pfam; PF00041; fn3; 8.
DR SMART; SM00181; EGF; 14.
DR SMART; SM00186; FBG; 1.
DR SMART; SM00060; FN3; 8.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 6.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50853; FN3; 7.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1695
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019259082"
FT DOMAIN 672..762
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 763..852
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 853..948
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1035..1125
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1126..1216
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1293..1381
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1383..1471
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1469..1684
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
SQ SEQUENCE 1695 AA; 186520 MW; D659B4FBBCBF45D4 CRC64;
MGVMTQLWAG LFLALLALPA EGGVLKKVIR HKRQSGVNVT LPEENQPVVF NHVYNIKLPV
GSQCSVDLES ASGEKDLAPP SEPQESFQEH TVDGENQIVF THRINIPRRA CGCAAAPDVK
ELLSRLEELE NLVSSLREQC TSGAGCCLQS AEGRVDTRPF CSGRGNFSTE GCGCVCEPGW
KGPNCSEPEC PGNCHLRGQC LDGQCVCDEG FTGEDCGLLA CPSDCNDQGK CVDGACVCFE
GYSGLDCSQE TCPVPCSEEH GRCVDGRCVC QEGFAGEDCR EPLCLHNCHG RGRCVENECV
CDEGFTGEDC GELVCPNDCF DRGRCLNGTC SCDEGFTGED CGQLACPHAC HGRGRCDEGQ
CVCDEGFAGP DCSERRCPSD CHERGRCVDG RCECNDGFTG ADCGELRCPR DCSGHGHCVN
GQCVCDEGHT GEDCAQRRCP SDCHGRGRCV DGRCECQPGF QGDDCGEMSC PHDCHQHGRC
VNGMCVCDDA YTGEDCRELR CPQDCSQRGR CVDGRCVCED GFTGPDCADL ACPGDCHGRG
RCVDGQCVCL EGFTGPDCAQ RRCPGDCHGQ GRCVDGQCVC HEGFTGPDCA QRSCPNDCSN
WGQCVSGRCI CNEGYTGEDC SQDLCVTLNT HTHVRTTSYL GVRGSERFWN CPKDTQLIDH
TMKRLPPFYL PTPEGLKFKS IKETSVEVEW DPLDIAFETW EVIFRNMNKD DEGEITKSLR
RPETTYRQTG LAPGQEYEIS LHIVKNNTRG PGLKRVTTTR LDAPSQIEVK DVTDTTALIT
WSKPLAEIDS IELTYGVKDV PGDRTSIDLT HEENQYSIGN LKPDTEYEVA LISRRVDMSS
NPAKETFTTG LDAPRNLRRI SQTDNSITLE WRNVKAAANS YRIKYAPISG GDHAEVEVPR
SRQTTTRTTL TGLRPGTEYG IGVSAVKGDK ESDPATINAA TELDTPKDLR VSEPTETSLT
LLWRTPVAKF DRYRLNYSLP SGQPVEVQLP RDTTSYVLRG LEPGQEYTVL LTAEKGRHKS
KPARLQASTG EALPLLENLT ISDINPYGFT VSWMASENAF DSFLVTVVDS GKLLDPQEFT
LSGTQRKLEL RGLITGIGYE VMVSGFTQGH QTKPLRAEII TEAEPEVDNL LVSDATPDGF
RLSWTADEGV FDSFVLKIRD TKKQSEPLEI TLLAPERTRD ITGLREATEY EIELYGVSSG
RRSQPVTAIA TTAMGSPKEI IFSDITENAA TVSWTAPTTQ VESFRITYVP IAGGRALGVQ
ELDRQQSSCG LMSYPMADYL SNTSLSFLAA LDGPSSLVTA NITDSEALAM WQPAIAPVDN
YVISYTGERV PEITRMVSGN TVEYALTNLE PATEYTLRIF AEKGPHLLTY LILNVFSSPD
LDSPRDFTAT EVQSESALLT WRPPRASVTG YLLVYESVDG TIKEVVVDPD TTSYSLTDLS
PSTYYTARIQ ALNGTLRSKT VKTIFTTTGV LYRFPRDCSQ AMLNGDTTSG VYTIYLNNDK
TQKQEVFCDM TSDGGGWIVF LRRKNGREDF YRNWKAYAAG FGDLKEEFWI GLDTLSKITA
QGQYELRVDL RDHGQSAYAV YDKFSVGDAR TRYRLKVEGY SGTAGDSMAY HNGRSFSTFD
KDTDSAITNC ALSYKGAFWY KNCHRVNLMG RYGDNSHSQG VNWFHWKGHE HSIQFAEMKL
RPSNFRNLEG RRKRA
//
