ID A0A452FGD6_CAPHI Unreviewed; 1159 AA.
AC A0A452FGD6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Folliculin interacting protein 1 {ECO:0000313|Ensembl:ENSCHIP00000023423.1};
GN Name=FNIP1 {ECO:0000313|Ensembl:ENSCHIP00000023423.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000023423.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000023423.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000023423.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004656}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the FNIP family.
CC {ECO:0000256|ARBA:ARBA00007541}.
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DR EMBL; LWLT01000008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452FGD6; -.
DR Ensembl; ENSCHIT00000031283.1; ENSCHIP00000023423.1; ENSCHIG00000020997.1.
DR GeneTree; ENSGT00390000009391; -.
DR Proteomes; UP000291000; Chromosome 7.
DR Bgee; ENSCHIG00000020997; Expressed in longissimus thoracis muscle and 17 other cell types or tissues.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR037545; DENN_FNIP1/2.
DR InterPro; IPR028086; FNIP_C_dom.
DR InterPro; IPR026156; FNIP_fam.
DR InterPro; IPR028085; FNIP_mid_dom.
DR InterPro; IPR028084; FNIP_N_dom.
DR PANTHER; PTHR21634:SF12; FOLLICULIN-INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR21634; UNCHARACTERIZED; 1.
DR Pfam; PF14638; FNIP_C; 1.
DR Pfam; PF14637; FNIP_M; 1.
DR Pfam; PF14636; FNIP_N; 1.
DR PRINTS; PR02073; FOLLICULNIP1.
DR PROSITE; PS51836; DENN_FNIP12; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 37..1153
FT /note="UDENN FNIP1/2-type"
FT /evidence="ECO:0000259|PROSITE:PS51836"
FT REGION 92..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 931..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..801
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..956
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1159 AA; 129359 MW; 3D0C628391A3C4AB CRC64;
MAPTLFQKLF SKRNGLGAPG RDARDPDCAF SWPLPEFDPS QIRLIVYQDC ERRGRNVLFD
SSVKRKNEDI SVSKLCSDAQ VKVFGKCCQL KPGGDSSSSL DSSLTASSDV KDQCPKYQGS
RCSSDANMLG EMMFGSVAMS YKGSTLKIHQ IRSPPQLMLS KVFTARTGSS ICGSLNTLQD
SLEFINQDNS TLKADNTVIN GLLGNIGLSQ FCSPRRAFSE QGPLRLIRSA SFFAVHSNPM
DMPGRDLNED RDSGIARSAS LSSLLITPFP SPNSSLTRSC ASSYQRRWRR SQTTSLENGV
FPRWSVEESF NLSDESCGPN PGIVRKKKIA IGVIFSLSKD EDESNKFNEF FFSHFPLFES
HMNKLKSAIE QAMKMSRRSA DASQRSLAYN RIVDALNEFR TTICNLYTMP RIGEPVWLTM
MSGTPEKNQL CHRFMKEFTF LMENASKNQF LPALITAVLT NHLAWVPTVM PNGQPPIKIF
LEKHSSQSVD MLAKTHPYNP LWAQLGDLYG AIGSPVRLAR TVVVGKRQDM VQRLLYFLTY
FIRCSELQET HLLENGEDEA IVMPGTVITT TLEKGEIEES EYVLITMHRN KSSLLFKESE
ETRTPNCNCK YCSRPLLGQN TENVLRQERE DIQNSSKELL GISNECQMIS PDCQEENAPD
VKQYRDKSRT CLDTKLETVV CTGSAPVDRC ALSKSGLDLA EETWQNEELL DSGNHAGKVL
RSAGMVVEKK PPDKLVTAAF SCEATQTKVT FLIGDSMSPD SDTELRSQAV VDQITRHHTK
SPKEERGAVD QHQETKQTTK SEESDIPNIV SGEPCERPCW NHSDLESMSL FDEYFNDDSI
ETRTIDDIPL KTSTDSKQHC CMLEFSKRLC TKNSKPNNEC CKCVGTVHQD SCKTCFPQQD
QRDTLSILVP HGDKESSEKK IAVGAEWDIP RNESSDSALG DSESEDTGQD VARQGNSYYG
GEQEDWAEED EIPFPGSKLI EVSAVQPNIA NFGRSLLGGY CSSYVPDFVL QGIGNDERLR
QCLVSDLSHA VQHPVLDEPI AEAVCIIADM DKWTVQVASS QRRMTDNKLG KEVLVSSLVS
NLLHSTLQLY KHNLSPNFCV MHLEDRLQEL YFKSKMLSEY LRGQMRVHVK ELGVVLGIES
SDLPLLAAVA STHSPLSSE
//
