ID A0A452FGI0_CAPHI Unreviewed; 796 AA.
AC A0A452FGI0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Nuclear factor of activated T cells 1 {ECO:0000313|Ensembl:ENSCHIP00000023386.1};
GN Name=NFATC1 {ECO:0000313|Ensembl:ENSCHIP00000023386.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000023386.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000023386.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000023386.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452FGI0; -.
DR Ensembl; ENSCHIT00000031246.1; ENSCHIP00000023386.1; ENSCHIG00000020951.1.
DR GeneTree; ENSGT00940000157616; -.
DR Proteomes; UP000291000; Chromosome 24.
DR Bgee; ENSCHIG00000020951; Expressed in longissimus thoracis muscle and 16 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd07881; RHD-n_NFAT; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF5; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 1; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 389..571
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 181..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..796
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 796 AA; 84798 MW; BE9305F2B079B532 CRC64;
MTGLEEDQEF DFDFLFEFNQ SDEGAVAAPA EHYGYATPGL GAGLPLSAAH PSLPAPCHDL
QSSAAGVSTV GYGGAVDSGP SGYFLSSGGI RPNGAPALES PRIEITSYLG LHHSSSQFLH
EVDVEDVLPK RSPSTATLNL PSLEAYRDPS CLSPASSLSS RSCNSEASSY ESSFSYPYAS
PQTSPWQSPC VSPKTTDPEE GFPRGLGACG LLGSPRHSPS TSPRTSVTEE SWLGARTSRP
SSPCNKRKYG LDGRQLSCSP HPSPTPSPQG SPRVSVTDDT WLGNTTQYTS SAIVAAINAL
STDSSLDLGD GVPVKARKTT LDHSPAVALK VEPAGEELGA TPPRRGAQPE VLAAPPHIGK
GAFCDQYLLV PQHPYPWARP RSPTPCASPS LPALDWQLPS HSGPYELRIE VQPKSHHRAH
YETEGSRGAV KASAGGHPSV QLHGYVESEP LTLQLFIGTA DDRLLRPHAF YQVHRITGKT
VSTASHEAVV CSTKVLEIPL LPENSMRATI DCAGILKLRN SDIELRKGET DIGRKNTRVR
LVFRVHIPQP NGRTLSLQVA SNPIECSQRS AQELPLVEKQ SAASGPVLGG KRMVLSGHNF
LQDSKVIFVE KAPDGHHIWE MEAKTEGDLC KPNSLVVEIP PFRNQRITSP VQVSFYVCNG
KRKRSQYQHF TYLPANVPII KTEPSDDYEP ALTCGPMSQG LSPLPKPCYG QPLALPPDPG
ACLMPGFPSR PQGSASPELH DLSCAPYGSA TAGPGHSPLG LPRPVGGVLA SQEAPRPSGV
PPGPPQPPPP TLLQPQ
//
