ID A0A452FGY9_CAPHI Unreviewed; 565 AA.
AC A0A452FGY9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=SHC adaptor protein 2 {ECO:0008006|Google:ProtNLM};
GN Name=SHC2 {ECO:0000313|Ensembl:ENSCHIP00000023618.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000023618.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000023618.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000023618.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LWLT01000008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452FGY9; -.
DR STRING; 9925.ENSCHIP00000023618; -.
DR Ensembl; ENSCHIT00000031478.1; ENSCHIP00000023618.1; ENSCHIG00000021094.1.
DR GeneTree; ENSGT00950000182870; -.
DR Proteomes; UP000291000; Chromosome 7.
DR Bgee; ENSCHIG00000021094; Expressed in cerebellum and 16 other cell types or tissues.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01209; PTB_Shc; 1.
DR CDD; cd09925; SH2_SHC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006019; PID_Shc-like.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035676; SHC_SH2.
DR PANTHER; PTHR10337; SHC TRANSFORMING PROTEIN; 1.
DR PANTHER; PTHR10337:SF5; SHC-TRANSFORMING PROTEIN 2; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00629; SHCPIDOMAIN.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 132..314
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 470..561
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 61329 MW; A56EE523EFD94F7E CRC64;
HSSSPGWRLT PPPPPPEPEA PTTFCALLPR MPQWKFAAPA GFLSRGPRRR GRRGPAGVPA
LAAAVLGACE PRCAAPCPLP ALSRCRAAGV RGPRGARGAT GPPDASGDEW IRKGSFIHKP
AHGWLHPDAR VLGPGVSYVV RYMGCIEVLR SMRSLDFSTR TQVTREAINR LHEAVPGVRG
SWKKKAPNKA LASILGKSNL RFAGMSIAVS ISIDGLNLSV PATRQIIANH HMQSISFASG
GDTDMADYVA YVAKDPINQR ACHILECCEG LAQSVISTVG QAFELRFKQY LHSPPRVVVP
PERLTGMEDS AWGDEEEAEH NYYNSLPGKE PPLGGLVDSR LALTQPCALG GASPARRDAR
SLQWDVGPSG TTQPGDGYVQ ADARGPRDYE DHLYVNTQGL DGPEPLRPED SPKKDLFDMR
PFEDALRLHE CSVAAGTVAA PLPVEDQWPS PPTRRAPVAP TEEQLRQEPW YHGQMSRRAA
EKLLRADGDF LVRDSASSPG QYVLTGMQAG QPKHLLLVDP EGVVRTKDVL FESISHLIDY
HLQNGQPIVA AESELHLRGV VKREP
//
