ID A0A452FI74_CAPHI Unreviewed; 284 AA.
AC A0A452FI74;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=tRNA N(3)-methylcytidine methyltransferase {ECO:0000256|PIRNR:PIRNR037755};
DE EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR037755};
GN Name=METTL6 {ECO:0000313|Ensembl:ENSCHIP00000023807.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000023807.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000023807.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000023807.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase.
CC {ECO:0000256|PIRNR:PIRNR037755}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. METL family.
CC {ECO:0000256|ARBA:ARBA00009725, ECO:0000256|PIRNR:PIRNR037755}.
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DR EMBL; LWLT01000001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005675770.2; XM_005675713.2.
DR AlphaFoldDB; A0A452FI74; -.
DR STRING; 9925.ENSCHIP00000023807; -.
DR Ensembl; ENSCHIT00000031667.1; ENSCHIP00000023807.1; ENSCHIG00000021242.1.
DR GeneID; 102179421; -.
DR KEGG; chx:102179421; -.
DR CTD; 131965; -.
DR GeneTree; ENSGT00940000156679; -.
DR OMA; DAQRNWD; -.
DR OrthoDB; 5471626at2759; -.
DR Proteomes; UP000291000; Chromosome 1.
DR Bgee; ENSCHIG00000021242; Expressed in testis and 17 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0052735; F:tRNA (cytidine-3-)-methyltransferase activity; IEA:Ensembl.
DR GO; GO:0030488; P:tRNA methylation; IEA:Ensembl.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR026113; METTL2/6/8-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22809; METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR22809:SF5; TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR PIRSF; PIRSF037755; Mettl2_prd; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|PIRNR:PIRNR037755};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR037755};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 84..182
FT /note="Methyltransferase type 12"
FT /evidence="ECO:0000259|Pfam:PF08242"
SQ SEQUENCE 284 AA; 33286 MW; 52AF3B3BCA30CA95 CRC64;
MAALQRRGLQ TRILSSEEEE KLKRDQALVS DFKQQKLEKE AQKNWDLFYK RNSTNFFKDR
HWTTREFEEL RSCREFEDQK LTILEAGCGV GNCLFPLLEE DPDIFAYACD FSPRAVEYVK
QNPLYDTERC KVFQCDLTKD DLLEHVPPES VDAVTLIFVL SAVHPDKMHL VLQNIYKVLK
PGRSVLFRDY GLYDHAMLRF KAGSKLAENF YVRQDGTRSY FFTDEFLARL FLDAGYEEEV
NEYVFRETVN KKEGLCVPRV FLQSKFRKSQ KTPVPVSPDL GHES
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