ID A0A452FIQ6_CAPHI Unreviewed; 699 AA.
AC A0A452FIQ6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Methyltransferase 13, eEF1A lysine and N-terminal methyltransferase {ECO:0000313|Ensembl:ENSCHIP00000024157.1};
GN Name=METTL13 {ECO:0000313|Ensembl:ENSCHIP00000024157.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000024157.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000024157.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000024157.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; LWLT01000016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017915802.1; XM_018060313.1.
DR STRING; 9925.ENSCHIP00000024157; -.
DR Ensembl; ENSCHIT00000032017.1; ENSCHIP00000024157.1; ENSCHIG00000021452.1.
DR Ensembl; ENSCHIT00010040981.1; ENSCHIP00010029057.1; ENSCHIG00010021615.1.
DR GeneID; 102176251; -.
DR KEGG; chx:102176251; -.
DR CTD; 51603; -.
DR GeneTree; ENSGT00510000047399; -.
DR OMA; REIEWLF; -.
DR OrthoDB; 179741at2759; -.
DR Proteomes; UP000291000; Chromosome 16.
DR Proteomes; UP000694566; Chromosome 16.
DR Bgee; ENSCHIG00000021452; Expressed in uterine horn and 17 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:Ensembl.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1902807; P:negative regulation of cell cycle G1/S phase transition; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd02440; AdoMet_MTases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF037959; MFS_SpdSyn; 1.
DR PANTHER; PTHR12176:SF78; EEF1A LYSINE AND N-TERMINAL METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12176; SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN; 1.
DR Pfam; PF13847; Methyltransf_31; 1.
DR Pfam; PF01564; Spermine_synth; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 47..162
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13847"
FT REGION 433..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 699 AA; 78837 MW; AF886C5CA33C5BED CRC64;
MNLLPKSSKE FGSVDYWEKF FQQRGKKAFE WYGTYLELCG VLHKYIKPRE KVLVVGCGNS
ELSEQLYDVG YQDIVNIDIS EVVIKQMKER NASRRPRMSF LKMDMTQMEF PDASFQVVLD
KGTLDAVLTD EEEKTLQQVD RMLAEVGRVL QVGGRYLCIS LAQAHVLKKA VGHFSREGWM
VRVHQVASSQ DQLLEAEPRF SLPVFAFIMT KFRPVTGSAL QIFELCAQEQ GKPVRLESAE
RLAEAVRERQ QYAWLCSQLY RKAGLGSVSL DLCNGDTGEP RYTLHVVDSP TVKPSRDNHF
AIFIIPQGRE TEWLFGMEEG RKQLAASAGF RRLITVALHR GQQYEGMDSI QAELSARVME
LAPAGMPAQL QVPFLSVGGD IGVRIVQHQD CSPLSGDYVI EDVQGDDRRY FRRLIFLSNR
NVVQSEARLL QDVSHRAQKK RKKDRKKHRP ADTPEDLPAA PGQSIDKSYL CCEHHKAMIA
GLALLKNPER LLETPLALLV VGLGGGSLPL FIHDHFPKSC IHAVEIDPSM LEVATQWFGF
SQSDRMKVHI ADGLDFITRL AEEEARPHYD VIMFDVDSKD PTLGMSCPPP AFVAQLFLQK
VKSILTSEGV FILNLVCRDL GLKDSVLAGL KAVFPLLYVR RIEGEVNEIL FCQLHSESKL
ATPELLEMAR ALEQTLRKPG KGWDDTYVLS DMLNTVKIV
//
