ID A0A452FJQ3_CAPHI Unreviewed; 857 AA.
AC A0A452FJQ3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Very low density lipoprotein receptor {ECO:0000313|Ensembl:ENSCHIP00000024386.1};
GN Name=VLDLR {ECO:0000313|Ensembl:ENSCHIP00000024386.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000024386.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000024386.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000024386.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; LWLT01000007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452FJQ3; -.
DR Ensembl; ENSCHIT00000032246.1; ENSCHIP00000024386.1; ENSCHIG00000021572.1.
DR GeneTree; ENSGT00940000155460; -.
DR Proteomes; UP000291000; Chromosome 8.
DR Bgee; ENSCHIG00000021572; Expressed in uterus and 18 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 8.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 782..803
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 380..415
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 465..508
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 509..551
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 552..595
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 596..640
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 17..29
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 24..42
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 36..51
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 56..68
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 63..81
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 118..133
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 138..150
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 145..163
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 157..172
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 177..189
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 184..202
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 223..235
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 230..248
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 242..257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 262..274
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 269..287
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 281..296
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 310..328
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 384..394
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 857 AA; 94475 MW; 61BDF5EB983E1B0E CRC64;
CKPKLCTAAF LGRKAKCEAS QFQCTNGRCI TLLWKCDGDE DCTDGSDEKN CVKKTCAESD
FVCNNGQCVP NRWQCDGDPD CEDGSDESPE QCHMRTCRIN EISCGARSTQ CIPVSWRCDG
ENDCDSGEDE ENCGNITCSS DEFTCSSGRC ISRNFMCNGQ DDCSDGSDEL DCAPPTCGPH
EFQCSTSSCI PISWVCDDDA DCSDQSDESL EQCGRQPVIH TRCPASEIQC GSGECIHKKW
RCDGDPDCKD GSDEVNCPSR TCRPDQFECE DGSCIHGSRQ CNGIRDCVDG SDEVNCKNVN
QCLGPGKFKC RSGECIDISK VCNQKQDCRD WSDEPLKECH VNECLVNNGG CSHICKDLVI
GYECDCAAGF ELIDRKTCGD IDECQNPGIC SQICINLKGG YKCECSRGYQ MDLATGVCKA
VGKEPSLIFT NRRDIRKIGL ERKEYIQLVE QLRNTVALDA DIAAQKLFWA DLSQKAIFSA
SIDDKVGRHV KMIDNVYNPA AIAVDWVYKT IYWTDAASKT ISVATLDGTK RKFLFNSDLR
EPASIAVDPL SGFVYWSDWG EPAKIEKAGM NGFDRRALVT ADIQWPNGIT LDLIKGRLYW
LDSKLHMLSS VDLNGQDRRI VLKSLEFLAH PLALTIFEDR VYWIDGENEA VYGANKFTGL
ELATLVNNLN DAQDIIVYHE LVQPSGKNWC EEDVENGGCE YLCLPAPQIN DHSPKYTCSC
PNGYNLEENG QECQSAATTV NYNETKDTNT AEISPTSGLI PGGINLTTAV SEVNVPPKGT
SAAWAILPLL LLAMAAVGGY LMWRNWQHKN MKSMNFDNPV YLKTTEEDLS IDIGRHSASV
GHTYPAISVV STDDDLA
//