ID A0A452FKF7_CAPHI Unreviewed; 735 AA.
AC A0A452FKF7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
GN Name=LOC102174895 {ECO:0000313|Ensembl:ENSCHIP00000024875.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000024875.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000024875.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000024875.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
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DR EMBL; LWLT01000004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005709616.3; XM_005709559.3.
DR AlphaFoldDB; A0A452FKF7; -.
DR STRING; 9925.ENSCHIP00000024875; -.
DR Ensembl; ENSCHIT00000032736.1; ENSCHIP00000024875.1; ENSCHIG00000021886.1.
DR GeneID; 102174895; -.
DR KEGG; chx:102174895; -.
DR GeneTree; ENSGT00940000156511; -.
DR OMA; TYVCEGV; -.
DR OrthoDB; 5359770at2759; -.
DR Proteomes; UP000291000; Chromosome 3.
DR Bgee; ENSCHIG00000021886; Expressed in spleen and 18 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005178; F:integrin binding; IEA:InterPro.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR047012; ICAM_VCAM.
DR InterPro; IPR003987; ICAM_VCAM_N.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR008424; Ig_C2-set.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR003989; VCAM-1.
DR PANTHER; PTHR13771; INTERCELLULAR ADHESION MOLECULE; 1.
DR PANTHER; PTHR13771:SF14; VASCULAR CELL ADHESION PROTEIN 1; 1.
DR Pfam; PF05790; C2-set; 2.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 2.
DR PRINTS; PR01472; ICAMVCAM1.
DR PRINTS; PR01474; VCAM1.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 7.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..735
FT /note="Ig-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019446783"
FT TRANSMEM 701..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..110
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 224..306
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 314..394
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 512..596
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 601..685
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 735 AA; 81351 MW; 6B006D82026600F2 CRC64;
MLRKMFVIFG VSDILWMVFA VSQAFKVDMF PNEYKIFAQI GDSVSLTCSA TGCESPSFSW
RTQIDSPLNG KVKNEGTTSM LIMDPVSFGN EHQYLCTVTC KDMKREKAIR VEIYSFSKDP
EIRLSSPPEV GKPVTVTCSV PDVYPFERLE IELLKSNRSM KVQEFLEPSE KKAQETKSLE
VTFSPTDEDI GKALVCQATL HIYDDDSPPK ERKTMKELEV YISPKDTAIS VNPSTRLQEG
DSVTMTCTSA GLPAPRILWS KKLDNGNLQL LSENATLTLI SMRAEDSGIY VCEGDNPVGK
DRKEVKLIVQ EKNFTVEISP GPQIAAQIGH SVVLTCDVRD CESPSFSWRT QIDSPLNGKV
RREGSKSTLT LSPVSVENEH FYLCTVMCGQ KKLEKGIQVK PYSFPSDPEI EMSGPLVSGN
PVTVSCKVPN VYPFDRLEIE LFKGESIMMN KVFSKDVSKK ALETKSLEKT FIPTAEDTGN
VLVCLARLPI DEMEFEPKQR QSTQTLYVNV APRDTTISVS PSSILEEGSS VNMTCSSNGL
PAPKILWSRQ LSNGDLQPIS ENETLTFMST KMEDSGIYVC EGINQVGISR KEVKLIIQVA
PKDTQLTAFP SESVKEGDTV IISCTCGNVP PTLIILKKKA ETGYTVLKST GGAYTIHRAQ
LEDAGVYQCE SKNEVGSQLR SLTLDVKGRE GNKDYFSPEL LVLYCAFFLI IPAIGMIIYF
ARKANMTGSY SLVEA
//
