ID A0A452FLM9_CAPHI Unreviewed; 958 AA.
AC A0A452FLM9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Pleckstrin and Sec7 domain containing 3 {ECO:0000313|Ensembl:ENSCHIP00000025300.1};
GN Name=PSD3 {ECO:0000313|Ensembl:ENSCHIP00000025300.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000025300.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000025300.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000025300.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle membrane
CC {ECO:0000256|ARBA:ARBA00004632}.
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DR EMBL; LWLT01000029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017897350.1; XM_018041861.1.
DR RefSeq; XP_017897352.1; XM_018041863.1.
DR Ensembl; ENSCHIT00000033162.1; ENSCHIP00000025300.1; ENSCHIG00000022134.1.
DR Ensembl; ENSCHIT00000033208.1; ENSCHIP00000025346.1; ENSCHIG00000022134.1.
DR GeneID; 102169072; -.
DR CTD; 23362; -.
DR GeneTree; ENSGT00940000156591; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000291000; Chromosome 27.
DR Bgee; ENSCHIG00000022134; Expressed in prefrontal cortex and 16 other cell types or tissues.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13295; PH_EFA6; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF337; PH AND SEC7 DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000291000}.
FT DOMAIN 459..644
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 695..808
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 19..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..671
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..958
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 958 AA; 104850 MW; 8E9E0DB15AAC2A13 CRC64;
MEGSGEGLRA SLEFDAESLL RCPGGPQGAQ PLASRHSGPV TVTGGPKDIR GLPSQSHFKE
PSLQPIDSLI SALKATEARI ASGTSQATKV LDGAAVSTFS AQQGGQEPDT ASHKARKAHA
LFPAGCEKSP DIPLSAKVPT EEHFYLSIQE DLTALLTGET QAEPSLRASN GRKGAVHVQE
PAGPASSVGS PATPSSAGGA SLLRERRSDQ REHPGQYARG RPGQGKHVAF QGVETPWTGG
EEGENRHPEG VQMPPGRTAP PESKEFSKVP SHLVLSAALR DSAAPPERPC PAEPLLETVE
DEVFLREDKE HLERRAEPER AGERILEQVE HFRGGDDDIL GSGYAEDSTD VYSSQFETIL
DNTSLYYSAE SLETLYSEPD SYFSFEMPLT PMIQQRIKEG GQFLERTSAG GQQDVLSISA
DGGIVMGCSS GIANGLSGSS NSIYSKGTPE ITFWGSNAGV KTALLEAHSE MGSTEILEKE
ASGGLSNCTS SNIEAAKRLA KRLYQLDRFK RSDVAKHLGK NNEFSKLVAE EYLKFFDFTG
MTLDQSLRYF FKAFSLVGET QERERVLVHF SNRYFYCNPD TIASQDGVHC LTCAMMLLNT
DLHGHNIGKK MTCQEFIANL QGVDEGGDFS KDLLKALYNS IKNEKLEWAV DDEEKKKSVS
EGADEKANGT HPKSISRIGS TTNPFLDIPH DPNAAVYKSG FLARKIHADM DGKKTPRGKR
GWKTFYAVLK GTVLYLQKDE YKPEKALSEE DLKNAVSVHH ALASQATDYE KKPNVLKLKT
ADWRVLLFQA QSLEEMQGWI SKINCVAAVF SAPPFPAAIG SQKKFSRPLL PATTTKLSQE
EQLKSHESKL RQITTELAEH RSYPPDKKVK AKEVDEYKLK DHYLEFEKTR YEMYVRLLKE
GGLELLSGGR GGPAGLKKSH SSPSLNPDTS PVTAKVKRNV SERKEHRPET PSIKQKVT
//
