ID A0A452FLY6_CAPHI Unreviewed; 3154 AA.
AC A0A452FLY6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=FRAS1 related extracellular matrix 2 {ECO:0000313|Ensembl:ENSCHIP00000025411.1};
GN Name=FREM2 {ECO:0000313|Ensembl:ENSCHIP00000025411.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000025411.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000025411.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000025411.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR EMBL; LWLT01000013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSCHIT00000033274.1; ENSCHIP00000025411.1; ENSCHIG00000022176.1.
DR GeneTree; ENSGT00940000155313; -.
DR OMA; ILPWELN; -.
DR Proteomes; UP000291000; Chromosome 12.
DR Bgee; ENSCHIG00000022176; Expressed in adult mammalian kidney and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 5.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR045658; FRAS1-rel_N.
DR PANTHER; PTHR45739:SF4; FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 2; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 5.
DR Pfam; PF19309; Frem_N; 1.
DR SMART; SM00237; Calx_beta; 5.
DR SUPFAM; SSF141072; CalX-like; 5.
DR PROSITE; PS51854; CSPG; 12.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..3154
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019577875"
FT TRANSMEM 3094..3119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 305..399
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 424..523
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 546..657
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 682..789
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 810..901
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 927..1019
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1048..1150
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1171..1264
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1285..1381
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1402..1494
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1514..1603
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1637..1734
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT DOMAIN 1741..1840
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 1853..1964
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 1978..2085
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2100..2202
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2220..2324
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT REGION 3017..3041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3121..3154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3154 AA; 349267 MW; F131458B8C185CFC CRC64;
FLPLLPWSPP TPPTPPGLVL LLLLSLVSRV RAQPPDPGLA LLSPDLAGVA GVPAEEAIVL
ANRGLRVPFG REVWLDPLQD LVLQVQPGDR CAVTVLDNDA LAQRPGRLSP KRFPCDFGAG
EVRYSHLGAR SPSRDRVRLQ LRYDAPGGAA VLPLVLEVEV VFTQLEVVTR NLPLVVEELL
GTSNALDARS LEFAYQPETE ECRVGILSGL GALPRYGELL HYPQIPGPAS KGDTQEPLLM
DCKAFQELGV RYRHTAPSRS PNRDWVPMVV ELRSRGSPVG SPALKREHFQ VLVRIRGGAE
NTAPKPSFVA MMMMEVDQFV LTALTPDMLA AEDAESAPDL LIFNLTSPFQ PGQGFLVSTD
DRSLPLSSFT QRDLHLLKIA YQPPSEDSDQ ERLFELELEV VDPEGAASDP FSFMVVVKPM
NTLAPVVTRN TGLILYEGQS RPLTGPAGSG PQNLVISDED DLEAVQLEVV AGLRHGHLVL
LGASSGNSAP KTFTVAELAA GRVVYHHDNK DGSLSDNLVL RMVDGGRRHQ VQFLFPITLV
PVDDQPPVLN ANTGLTLAEG ETVPILPQAL SATDMDSEDS LLLFVLEAPS STAGHLLLRQ
THPPQGEEIP WRKQGVFYEK TVTEWRQRDI TEGRLFYRHS GPHSPGPVID QFTFRVQDNH
DPPNKSGLQR FVIRIHSVDR LPPELGSGCP LRMVVQESQL TPLRKKWLRY TDLDTDDREL
RYTVTQPPMD TDENHSPAPL GTLVLTDDPS VVVAHFTQAQ VNHHKIAYRP PDQELGVAAR
VAQFQFQVED QAGNVAPGTF TFYLQPVDNQ PPEILNTGFT VQEKSHHILS ETELGVNDVD
TDVAHITFTL IQVPKHGHMQ LSGQVLHVGG IFHLEDIKQG RISYAHNEAE SLTDSCSLEV
SDGYHVVPIT LRVNVRPMDG ELPVLSLPAG TLGSYLDVLE NGATEITANV IRGTNGDADD
LMLTFLLEDA PLYGEILVNG VPAEQFTQRD ILEGSVVYSH TSGEIGLLPK EDSFNLSLSD
MSQEWRIGGN TIQGVTVWVT ILPVDSQAPE ISVGEQFIVL EGDKSVITSM HISAEDIDSL
NDDILCTIII QPTSGYVENI SPAPGSEKSR AGIAISAFTL KDLRQGHINY VQSVHKGVEP
VEDRFIFRCS DGINFSERHF FPIVIIPTND EQPEIFIREF MVMEGMSLVV DTPILNAADA
DVPPDDLTFT ITKVPTHGHI MNQQINGTVL VESFTLDQII ESSSIIYEHD DSETQEDSFV
IKLTDGRHSV EKTVLIMVIP VDDETPRMAI NNGLEIEIGE TKIINNRILM ATDLDSEDKF
LVYIIRYGPG HGLLRRQTPT GVFENITLGM NFTQGEVDRN LIQYVHFGQE GIRDLIKFDV
TDGINALIDR YFYVSIGSPD IVFPDVISKG VSLKEGGKVT LTTDLLSTSD LNSPDENLVF
TITRAPMRGH LESTDQPRVS ITSFTQLQLA GNKIYYIHTA DDEVKMDSFE FQVTDGRNPV
FRTFRISISD VDNKKPVVTI HNLVVSEGEK KLITPFELTV EDRDTPDKLL KFTVTQVPVH
GQLLFNNTRP AMIFTKQDLN ENLISYRHDG TESSEDSFSF TVTDGSHTEF YVFPDTAFET
RRPQVMKIQI LAVDNRVPQI VVNKGASTLR TLATGHLGFM ITSKVLKAED RDSLHVSLRF
IVTEAPRHGY LLNLGQGNHS VTEFTQADID DMKICYVLRE GANAISDIFH FTVEDGGGNK
LTKQHFRLNW AWISFEKEYY LINEDSKFLD VVLKRRGYLG ETSFISIGTR DGTAKKDKDF
KGKAQKQVQF NPGQTRATWR VRILSDGAHE QSETFQVVLS EPVLAALEFP TVTTVEIVDP
GDESTVFIPQ SEYSIEEDIG ELFIPIRRSG DVSQELMVIC YTRQGTARGT VPTSVLSYSD
YISRPEDHTS VIRFDKDERE KMCRVVIIDD SLFEEEETFH VLLSMPMGGR IGSEFPEAQV
TIRPDKDDEP VFYFGDVEYS VDESAGSVEV RVWRSGTDLS QASSVTVTSQ KTDPPSADAG
TDYVGISRNL DFAPGVNMQT VRVIILDDLG QPMLEGLEQF ELVLRMPMNA ALGDPSKATV
IINDSVSDLP KMQFKERVYT GNENDGQIVA MIHRSGDIQY RSSVRCYTRQ GSAQVMMDFE
ERPNTDISII TFLPGEIEKP CILGLMDDVL YEEIEELRLV LGTPQSNSPF GAAVGEQNET
LIRIRDDADK TIIKFGETKF SVSEPKEPGQ SVIIKIPVIR QGDTSKVSIV RVHTKDGSAT
SGEDYHPVSE EIEFKEGETQ HIVEIEVIFD GVREMREAFT VHLKPDENMI AETQATKAIV
YIEETNSVAD ATFPSVPQVV SLLMYDDPSR AKESAGPVSG YPVICITACN PKYSDYEKTG
SICASENIND TLTRYRWLIS APASPDGVTS PMREVDFDTF FTSSKMITLD SIYFQPGSRV
QCAARAVNAD GSEGLELMSP IVTIGREEGL CQPRVPGIVG AEPFSAKLRY TGPEDSEYTN
LIKLTVTMPH IDGMLPVIST KELSNFELTL SPDGTRVGNH KCSNLLDYTE VKTHHGFLTD
ATKNPEIIGE TYPYQYSSSI RGSNTLRFYR NLNLEACLWE FVSYYDMSEL LTDCGGTIGT
DGQVLNLVQS YVTLRVPLYV SYVFHSPVGV GGWQHFDLKS ELRLTFVYDT AILWTDGIGS
PPEAELQGSL YPTSMRIGEE GRLVVNFKTE AQFHGLFVLS HPASFTSSVI MSVNHPGLTF
SLRLIRSEPT YNQPVQQWSF VSDFAVRDYS GTYTVKLLPC TTPSHQEYRL PVTCNPREPI
TFDLDIRFQQ VSDPVAAEFS LNTQMYLLSK KSLWLSDGSM GFGQESDVAF AEGDIIYGRV
MVDPVQNLGD SFYCSIEKVF LCTGADGYVP KYNPTNAEYG CLADSPSLLY RFKIVDKAQP
ETQATSFGNV LFNAKLAVDD PEAILLVNQP GSDGFKVDST PLFQVALGRE WYIHTIYTVR
SKDNANRGIG KRSVEYRHHS LVSQGKPQAA TKSRKKREIR SSPPLAWEIG AENNRGTNIQ
HIALDRSSRK QILHGRVSPD GVLPPELNSP SSEVSLLTVV GGVAVGLLAV ILTAVAVMMH
QGKKGARRKD APKDPGSREP MMPSVSHHSD SSEV
//
