ID A0A452FMH3_CAPHI Unreviewed; 487 AA.
AC A0A452FMH3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Recombination signal binding protein for immunoglobulin kappa J region {ECO:0000313|Ensembl:ENSCHIP00000025239.1};
GN Name=RBPJ {ECO:0000313|Ensembl:ENSCHIP00000025239.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000025239.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000025239.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000025239.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Su(H) family.
CC {ECO:0000256|ARBA:ARBA00009704}.
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DR EMBL; LWLT01000006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_013820025.1; XM_013964571.2.
DR AlphaFoldDB; A0A452FMH3; -.
DR SMR; A0A452FMH3; -.
DR Ensembl; ENSCHIT00000033101.1; ENSCHIP00000025239.1; ENSCHIG00000022041.1.
DR GeneID; 102185075; -.
DR CTD; 3516; -.
DR GeneTree; ENSGT00390000005197; -.
DR OrthoDB; 1384914at2759; -.
DR Proteomes; UP000291000; Chromosome 6.
DR Bgee; ENSCHIG00000022041; Expressed in fallopian tube and 17 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01176; IPT_RBP-Jkappa; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.1450; LAG1, DNA binding domain; 1.
DR InterPro; IPR015350; Beta-trefoil_DNA-bd_dom.
DR InterPro; IPR036358; BTD_sf.
DR InterPro; IPR040159; CLS_fam.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR015351; RBP-J/Cbf11/Cbf12_DNA-bd.
DR InterPro; IPR037095; RBP-J/Cbf11_DNA-bd_sf.
DR InterPro; IPR038007; RBP-Jkappa_IPT.
DR PANTHER; PTHR10665; RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS; 1.
DR PANTHER; PTHR10665:SF3; RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS; 1.
DR Pfam; PF09270; BTD; 1.
DR Pfam; PF09271; LAG1-DNAbind; 1.
DR Pfam; PF20144; TIG_SUH; 1.
DR SMART; SM01268; BTD; 1.
DR SMART; SM01267; LAG1_DNAbind; 1.
DR SUPFAM; SSF110217; DNA-binding protein LAG-1 (CSL); 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 34..165
FT /note="RBP-J/Cbf11/Cbf12 DNA binding"
FT /evidence="ECO:0000259|SMART:SM01267"
FT DOMAIN 166..315
FT /note="Beta-trefoil DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01268"
FT REGION 452..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 487 AA; 54368 MW; 0EA738C7D8647942 CRC64;
MAPVVTGKFG ERPPPKRLTR EAMRNYLKER GDQTVLILHA KVAQKSYGNE KRFFCPPPCV
YLMGSGWKKK KEQMERDGCS EQESQPCAFI GIGNSDQEMQ QLNLEGKNYC TAKTLYISDS
DKRKHFMLSV KMFYGNSDDI GVFLSKRIKV ISKPSKKKQS LKNADLCIAS GTKVALFNRL
RSQTVSTRYL HVEGGNFHAS SQQWGAFYIH LLDDDESEGE EFTVRDGYIH YGQTVKLVCS
VTGMALPRLI IRKVDKQTAL LDADDPVSQL HKCAFYLKDT ERMYLCLSQE RIIQFQATPC
PKEPNKEMIN DGASWTIIST DKAEYTFYEG MGPVLAPVTP VPVVESLQLN GGGDVAMLEL
TGQNFTPNLR VWFGDVEAET MYRCGESMLC VVPDISAFRE GWRWVRQPVQ VPVTLVRNDG
IIYSTSLTFT YTPEPGPRPH CSAAGAILRA NSSQVPPNES NTNSEGSYTN VSTNSTNVTS
STATVVS
//
