ID A0A452FN74_CAPHI Unreviewed; 966 AA.
AC A0A452FN74;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Toll-like receptor {ECO:0000256|RuleBase:RU363040};
GN Name=TLR6 {ECO:0000313|Ensembl:ENSCHIP00000025720.1};
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925 {ECO:0000313|Ensembl:ENSCHIP00000025720.1, ECO:0000313|Proteomes:UP000291000};
RN [1] {ECO:0000313|Ensembl:ENSCHIP00000025720.1, ECO:0000313|Proteomes:UP000291000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Bickhart D.M., Koren S., Rosen B., Hastie A., Liachko I., Sullivan S.T.,
RA Burton J., Sayre B.L., Huson H.J., Lee J., Lam E., Kelley C.M.,
RA Hutchison J.L., Zhou Y., Sun J., Crisa A., Schwartz J.C., Hammond J.A.,
RA Schroeder S.G., Liu G.E., Dunham M., Shendure J., Sonstegard T.S.,
RA Phillippy A.M., Van Tassell C.P., Smith T.P.;
RT "Polished mammalian reference genomes with single-molecule sequencing and
RT chromosome conformation capture applied to the Capra hircus genome.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCHIP00000025720.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU363040}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU363040}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|RuleBase:RU363040}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU363040}.
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DR EMBL; LWLT01000006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A452FN74; -.
DR SMR; A0A452FN74; -.
DR STRING; 9925.ENSCHIP00000025720; -.
DR Ensembl; ENSCHIT00000033582.1; ENSCHIP00000025720.1; ENSCHIG00000022377.1.
DR GeneTree; ENSGT00940000162201; -.
DR OMA; CHHEKNF; -.
DR Proteomes; UP000291000; Chromosome 6.
DR Bgee; ENSCHIG00000022377; Expressed in spleen and 17 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR GO; GO:0035355; C:Toll-like receptor 2-Toll-like receptor 6 protein complex; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0035663; F:Toll-like receptor 2 binding; IEA:Ensembl.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:1904646; P:cellular response to amyloid-beta; IEA:Ensembl.
DR GO; GO:0071726; P:cellular response to diacyl bacterial lipopeptide; IEA:Ensembl.
DR GO; GO:0140052; P:cellular response to oxidised low-density lipoprotein particle stimulus; IEA:Ensembl.
DR GO; GO:0042496; P:detection of diacyl bacterial lipopeptide; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0032717; P:negative regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0038124; P:toll-like receptor TLR6:TLR2 signaling pathway; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF422; TOLL-LIKE RECEPTOR 6; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01463; LRRCT; 2.
DR Pfam; PF01582; TIR; 2.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00369; LRR_TYP; 6.
DR SMART; SM00082; LRRCT; 2.
DR SMART; SM00255; TIR; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 2.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 2.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|RuleBase:RU363040};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|RuleBase:RU363040};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|RuleBase:RU363040};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|RuleBase:RU363040};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU363040};
KW Reference proteome {ECO:0000313|Proteomes:UP000291000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|RuleBase:RU363040};
KW Transmembrane helix {ECO:0000256|RuleBase:RU363040}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363040"
FT TRANSMEM 586..610
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363040"
FT TRANSMEM 754..784
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363040"
FT DOMAIN 641..766
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT DOMAIN 809..950
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 966 AA; 110997 MW; A8ED8DB19B76E9A9 CRC64;
MIKDKESPIR SCHFVYIVAL VFGTIIQFSD ESEFVVDMSK TSLVHVPKDL PPNTKVLDLS
QNNISELHLS DVSFLSGLKV LRLSHNRIQG LDISIFKFNH DLEYLDLSHN QLQKISCHPI
TTSLKHLDLS FNDFDALPIC KEFGNLTQLN FLGLSATKLE QLDLLPVAHL HLSCILLDLE
DYYMKENKKE SLQILNTKKL HLVFHPNSFF SVQVKISVNS LGCLQLTNIK VNDDNCQVLL
KFLSELTGRP TLLNFTLNHM ETTWKCLVKV FQFLWPKPVE YLNIYNLTIV KSINEEDFTY
YKTTLKSLKI EYVTNEVFIF SQTALYTVFS EMNIPMLTIS DTPFIHMLCP QEPSTFKFLN
FTQNAFTDSV FQNCDTLTRL ETLILQKNEL KDLFKTSLMT KGMLSLETLD VSWNSLEYDR
RNGNCTWVGS IVVLNLSSNA LTDSVFRCLP PRIKVLDLHN NRIRSIPKDV TGLETLQELN
LASNSLAHLP GCGILSSLSI LIIDYNSISS PSADFFQSCQ KIRSLKAGNN PFQCSCELRE
FIQSVGQVSS DVVEGWPESY KCDYPESYQG TPLKDFHVSE LSCNTALLIV TIVVPGLVLA
VAVTVLCIYL DLPWYLRMVC QWTQTRRRAR NVPLEERQRT LQFHAFISYS EHDSAWVKNE
LIPNLEKEDI RICLHERNFV AGKSIVENII NCIEKRNNPF QCSCELREFI QSVGQVSSDV
VEGWPESYKC DYPESYKGTP LKDFHVSELS CNTALLIVTI VVPGLVLAVA VTVLCIYLDL
PWYLRMVCQW TQTRRRARNV PLEERQRTLQ FHAFISYSGH DSAWVKNELI PNLEKEDIRI
CLHERNFVAG KSIVENIINC IEKSYKSIFV LSPNFVQSEW CHYELYFAHH NLFHEGSDNL
ILILLEPIPQ YSIPSSYHKL RALMAQRTYL EWPKEKSKHG LFWANLRASI NIKLMGKAAE
VRYTEI
//
